Results 301 to 310 of about 2,667,642 (350)
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Lipoprotein receptors and atherosclerosis
Biochemical Society Transactions, 1989The whole lipoprotein spectrum of human plasma may be divided into atherosclerotic and anti-atherosclerotic lipoproteins. To the first class belong apolipoprotein (apo) B and some apoE-containing lipoproteins of the very-low-density (VLDL), intermediate-density (IDL) and low-density (LDL) lipoprotein fractions.
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Lipoprotein receptors: therapeutic implications
Journal of Hypertension, 1990Knowledge of the transport pathways for cholesterol in blood helps us to understand the mechanisms underlying genetic and acquired forms of hypercholesterolaemia, and sets the stage for rational treatment with diet and drugs. A key element is a cell-surface receptor that binds cholesterol-rich lipoproteins of intermediate and low density.
Joseph L. Goldstein, Michael S. Brown
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Lipoprotein and receptor interactions in vivo
Current Opinion in Lipidology, 1995A substantial number of animal models aimed at the genetic dissection of lipid metabolism have been generated recently. Transgenic and knockout mice, in which the receptors or apolipoproteins are overexpressed or destroyed, combined with virus-mediated gene transfer in vivo have advanced our understanding of the complex physiological and ...
Joachim Herz, Thomas E. Willnow
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Functional role of lipoprotein receptors in Alzheimer's disease.
Current Alzheimer Research, 2008The LDL receptor gene family constitutes a class of structurally closely related cell surface receptors fulfilling diverse functions in different organs, tissues, and cell types.
S. Jaeger, C. Pietrzik
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Lipoprotein Receptors and Endothelial Cells
Seminars in Thrombosis and Hemostasis, 1988The interaction of lipoproteins with endothelial receptors can result in alterations in macromolecular transport, in changes in monocyte adherence to the endothelium, and in the production of monocyte chemotactic factor by the endothelium. Monocyte migration in response to such factors can further alter lipoprotein transport into the subendothelial ...
A M Fogelman +4 more
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2002
Aspects of lipoprotein receptor-mediated metabolism of the major cholesterol- and triacylglycerol-carrying lipoproteins are described. The main apolipoproteins of these particles, apoB and apoE, are important recognition partners of relevant receptors. The introduction deals with general aspects of human lipoprotein metabolic pathways.
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Aspects of lipoprotein receptor-mediated metabolism of the major cholesterol- and triacylglycerol-carrying lipoproteins are described. The main apolipoproteins of these particles, apoB and apoE, are important recognition partners of relevant receptors. The introduction deals with general aspects of human lipoprotein metabolic pathways.
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Lipoprotein receptors in the vascular wall
Current Opinion in Lipidology, 2004We will discuss the diverse roles of lipoprotein receptors that contribute to the maintenance and integrity of the vascular wall.Lipoprotein receptors function not only as transporters for cholesterol and other lipids. They also act as sensors and signal transducers through which the endothelium, macrophages and smooth muscle cells communicate with ...
Joachim Herz, David Y. Hui
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Lipophorin receptor: The insect lipoprotein receptor
Resonance, 2013The low-density lipoprotein receptor (LDLR), one of the best characterized cell-surface receptors, mediates cholesterol homeostasis and other functions in mammals. The members of the LDLR superfamily are structurally related and characterized by distinct functional domains.
G. Ravikumar, N. B. Vijayaprakash
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The low density lipoprotein receptor
Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1989The study of familial hypercholesterolemia at the molecular level has led to its advancement from a clinical syndrome to a fascinating experimental system. FH was first described 50 years ago by Carl Müller who concluded that the disease produces high plasma cholesterol levels and myocardial infarctions in young people, and is transmitted as an ...
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Receptors for triglyceride-rich lipoproteins and their role in lipoprotein metabolism
Current Opinion in Lipidology, 1995The triglyceride-rich lipoproteins in normal human plasma are VLDL and chylomicrons and their remnants. Several receptors for these lipoproteins have been described, most of them belonging to the LDL receptor family. The LDL receptor itself is able to recognize remnants through apolipoprotein E.
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