Results 61 to 70 of about 2,989,463 (164)
JEADV Clinical Practice, EarlyView.Chronic kidney disease‐associated pruritus (CKDaP) is a frequent complication of advanced CKD with an incompletely understood pathophysiology. We identified a significantly altered glycine‐to‐taurine conjugated bile acid ratio in patients with CKDaP despite unchanged total serum bile acid concentrations.
Miriam M. Düll +6 more
wiley +1 more source
Communications BiologyLysophosphatidic acid receptor 1 (LPA1) is one of the G protein-coupled receptors activated by the lipid mediator, lysophosphatidic acid (LPA). LPA1 is associated with a variety of diseases, and LPA1 agonists have potential therapeutic value for treating
Hiroaki Akasaka +3 more
doaj +1 more source
Lysophosphatidic Acid (LPA) Induces Plasma Exudation and Histamine Release in Mice via LPA Receptors
Journal of Pharmacological Sciences, 2006 .: Lysophosphatidic acid (LPA), the simplest of the water-soluble phospholipids, can evoke various biological responses. The present study examined the activity of LPA to induce plasma exudation and histamine release in mice.
Terumasa Hashimoto +2 more
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Lipids in Health and Disease, 2021 Background Lysophosphatidic acid (LPA) is a bioactive lysophospholipid that acts through its six cognate G protein-coupled receptors. As a family, lysophospholipids have already produced medicines (e.g., sphingosine 1-phosphate) as is being pursued for ...
Manisha Ray +3 more
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Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine
Phytotherapy Research, EarlyView.By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao +11 more
wiley +1 more source
CYRI-B-mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake
eLifePancreatic ductal adenocarcinoma carries a dismal prognosis, with high rates of metastasis and few treatment options. Hyperactivation of KRAS in almost all tumours drives RAC1 activation, conferring enhanced migratory and proliferative capacity as well ...
Savvas Nikolaou +8 more
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Novel lysophosphoplipid receptors: their structure and function
Journal of Lipid Research, 2014 It is now accepted that lysophospholipids (LysoGPs) have a wide variety of functions as lipid mediators that are exerted through G protein-coupled receptors (GPCRs) specific to each lysophospholipid.
Kumiko Makide +6 more
doaj +1 more source
Alimentary Pharmacology &Therapeutics, EarlyView.Placebo arms show substantial improvement in cholestatic pruritus, with up to 30% response rate. Estimates differed across outcome instruments, highlighting the importance of endpoint selection and realistic placebo assumptions in future trial design.
Igor Boechat Silveira +8 more
wiley +1 more source
Lysophosphatidic Acid Signaling in the Nervous System [PDF]
, 2015 The brain is composed of many lipids with varied forms that serve not only as structural components but also as essential signaling molecules. Lysophosphatidic acid (LPA) is an important bioactive lipid species that is part of the lysophospholipid (LP ...
Mirendil, Hope +3 more
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Alimentary Pharmacology &Therapeutics, EarlyView.Among 200 patients with primary sclerosing cholangitis, 38% reported moderate to severe pruritus in the past 6 months. During 6 months of follow up, pruritus severity fluctuated significantly. Pruritus severity was linked to worse colitis activity and lower quality of life.
Richard Dean +16 more
wiley +1 more source