Results 81 to 90 of about 2,989,463 (164)

G-Protein-Coupled Lysophosphatidic Acid Receptors and Their Regulation of AKT Signaling

, 2016
A hallmark of G-protein-coupled receptors (GPCRs) is their ability to recognize and respond to chemically diverse ligands. Lysophospholipids constitute a relatively recent addition to these ligands and carry out their biological functions by activating G-
Riaz, Anjum,, Riaz, Anjum, Ying Huang, Johansson, Staffan, Anjum Riaz, Huang, Ying,, Huang, Ying, Johansson, Staffan,, Staffan Johansson   +8 more
core   +1 more source

Lysophosphatidic Acid and its Receptors LPA and LPA Mediate Paclitaxel-Induced Neuropathic Pain in Mice

Molecular Pain, 2014
Background: Paclitaxel, which is widely used for the treatment of solid tumors, causes neuropathic pain via poorly understood mechanisms. Previously, we have demonstrated that lysophosphatidic acid (LPA) and its receptors (LPA 1 and LPA 3 ) are required ...
Hitoshi Uchida, Jun Nagai, Hiroshi Ueda
doaj   +1 more source

Charting Morphotoxicity With Complementary Embryo Models

Advanced Healthcare Materials, Volume 15, Issue 35, 18 September 2026.
Three human embryo models of the peri‐implantation stages are exposed to a library of compounds. The (toxic) effects of the compounds are analyzed through automated image analysis pipelines. By evaluating the differential responses of the embryo models, this study underscores the importance of testing complementary embryo models to achieve robust and ...
Dorian G. Luijkx, Pauline L. Balder, Romy M. L. Verhagen, Vinidhra Shankar, Barry Jutten, Pinak Samal, Timo Rademakers, Clemens A. van Blitterswijk, Stefan Giselbrecht, Erik J. Vrij   +9 more
wiley   +1 more source

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

Advanced Science, Volume 13, Issue 53, 24 September 2026.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo, Hansen Lin, Haoqian Feng, Lei Tan, Xi Liu, Yong Huang, Junjie Cen, Jiajie Chen, Xinwei Zhou, Mingjie Lin, Wuyuan Liao, Zheyu Ai, Minyu Chen, Yinghan Wang, Wei Chen, Junhang Luo, Yanping Liang   +16 more
wiley   +1 more source

Multi-Target Protective Effects of Gintonin in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Mediated Model of Parkinson’s Disease via Lysophosphatidic Acid Receptors

Frontiers in Pharmacology, 2018
Gintonin is a ginseng-derived lysophosphatidic acid receptor (LPAR) ligand. Although previous in vitro and in vivo studies demonstrated the therapeutic role of gintonin against Alzheimer’s disease, the neuroprotective effects of gintonin in Parkinson’s ...
Jong Hee Choi, Jong Hee Choi, Minhee Jang, Seikwan Oh, Seung-Yeol Nah, Ik-Hyun Cho, Ik-Hyun Cho, Ik-Hyun Cho   +7 more
doaj   +1 more source

Gintonin absorption in intestinal model systems

Journal of Ginseng Research, 2018
Background: Recently, we identified a novel ginseng-derived lysophosphatidic acid receptor ligand, called gintonin. We showed that gintonin induces [Ca2+]i transient-mediated morphological changes, proliferation, and migration in cells expressing ...
Byung-Hwan Lee, Sun-Hye Choi, Hyeon-Joong Kim, Sang-Deuk Park, Hyewhon Rhim, Hyoung-Chun Kim, Sung-Hee Hwang, Seung-Yeol Nah   +7 more
doaj   +1 more source

Higher LPA2 and LPA6 mRNA Levels in Hepatocellular Carcinoma Are Associated with Poorer Differentiation, Microvascular Invasion and Earlier Recurrence with Higher Serum Autotaxin Levels.

PLoS ONE, 2016
Hepatocellular carcinoma (HCC) commonly develops in patients with liver fibrosis; in these patients, the blood levels of lysophosphatidic acid (LPA) and its generating enzyme autotaxin (ATX) increase with the liver fibrosis stage. We aimed to examine the
Kenichiro Enooku, Baasanjav Uranbileg, Hitoshi Ikeda, Makoto Kurano, Masaya Sato, Hiroki Kudo, Harufumi Maki, Kazuhiko Koike, Kiyoshi Hasegawa, Norihiro Kokudo, Yutaka Yatomi   +10 more
doaj   +1 more source

Molecular basis for lysophosphatidic acid receptor antagonist selectivity

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002
Recent characterization of lysophosphatidic acid (LPA) receptors has made possible studies elucidating the structure-activity relationships (SAR) for agonist activity at individual receptors. Additionally, the availability of these receptors has allowed the identification of antagonists of LPA-induced effects.
Vineet M, Sardar, Debra L, Bautista, David J, Fischer, Kazuaki, Yokoyama, Nora, Nusser, Tamas, Virag, De-an, Wang, Daniel L, Baker, Gabor, Tigyi, Abby L, Parrill   +9 more
openaire   +3 more sources

Canoe full of hot paddlers: TRPV1 neurons steering cardiorespiratory control

The Journal of Physiology, EarlyView.
Richard J. A. Wilson, Nicholas Jendzjowsky   +1 more
wiley   +1 more source

An autocrine role for pituitary GABA: Activation of GABA-B receptors and regulation of growth hormone levels [PDF]

, 2002
There is increasing evidence suggesting that the neurotransmitter gamma-aminobutyric acid (GABA) is a local factor involved in the regulation of endocrine organs.
Corsi, C., Pepeu, G., Gratzl, M., Gamel-Didelon, Katia, Jung, H., Mayerhofer, Artur   +5 more
core   +1 more source