Results 101 to 110 of about 2,989,463 (164)

Lysophosphatidic Acid (LPA) Signaling in Human and Ruminant Reproductive Tract

Mediators of Inflammation, 2014
Lysophosphatidic acid (LPA) through activating its G protein-coupled receptors (LPAR 1–6) exerts diverse cellular effects that in turn influence several physiological processes including reproductive function of the female.
Izabela Wocławek-Potocka, Paulina Rawińska, Ilona Kowalczyk-Zieba, Dorota Boruszewska, Emilia Sinderewicz, Tomasz Waśniewski, Dariusz Jan Skarzynski   +6 more
doaj   +1 more source

Lysophospholipid receptors in neurodegeneration and neuroprotection

Exploration of Neuroprotective Therapy
The central nervous system (CNS) is one of the most complex physiological systems, and treatment of CNS disorders represents an area of major medical need.
Eric Birgbauer
doaj   +1 more source

Interleukin-1β Expression Is Required for Lysophosphatidic Acid-Induced Lymphangiogenesis in Human Umbilical Vein Endothelial Cells

International Journal of Inflammation, 2011
Lysophosphatidic acid (LPA) is a lipid mediator which binds to G-protein-coupled receptors and regulates various cellular responses, including inflammation of endothelial cells.
Chih-Hsin Lin, JenHer Lu, Hsinyu Lee
doaj   +1 more source

Roles of lipid mediators in early pregnancy events

Reproductive Medicine and Biology
Background Early pregnancy events, including embryo implantation, are critical for maintaining a healthy pregnancy and facilitating childbirth. Despite numerous signaling pathways implicated in establishing early pregnancy, a comprehensive understanding ...
Shizu Aikawa, Yasushi Hirota
doaj   +1 more source

Lysophosphatidic acid induces vasodilation mediated by LPA1 receptors, phospholipase C, and endothelial nitric oxide synthase.

, 2013
Lysophosphatidic acid (LPA) has been implicated as a mediator of several cardiovascular functions, but its potential involvement in the control of vascular tone is obscure.
Nemeth T, Smrcka AV, Balogh, Andrea, Kerek M, Malik KU, Kerék, Margit, Tigyi, Gabor, Benyó, Zoltán, Liliom, Károly, Patil R, Ruisanchez, Éva, Dancs, Péter, Németh, Tamás, Faragó, Bernadett, Jennings BL   +14 more
core   +1 more source

Development of Bifunctional Lysophosphatidic Acid & Lysophosphatidylcholine Activity Probes to Characterize Their Specific Binding Protein Receptors [PDF]

, 2011
Lysophosphatidic acid (LPA) and lysophosphatidylcholine (LPC) activity has been found to be dysregulated in cancer cells and therefore is a crucial target for research.
Nandal, Ritu
core  

Lysophosphatidic acid induces process retraction in CG-4 line oligodendrocytes and oligodendrocyte precursor cells but not in differentiated oligodendrocytes

, 2003
Lysophosphatidic acid is a growth factor-like signalling phospholipid. We demonstrate here that lysophosphatidic acid induces process retraction in central glia-4 cells and oligodendrocyte precursors.
Hotchin, N., Dawson, J., Rumsby, M., Lax, S., Hotchin, Neil; id_orcid, Dawson, J, Lax, Sian; id_orcid, Rumsby, M   +7 more
core   +1 more source

Modulatory role of lysophosphatidic acid on opioid receptor binding

, 1998
Arachidonic acid (AA) and lysophosphatidic acid (LPA) are two important signaling molecules generated by the hydrolysis of membrane phospholipids by the action of phospholipase A2 (PLA2) enzymes.
Öktem, Hüseyin Avni, Apaydin, S.
core   +1 more source

Lysophosphatidic acid synthesis and release.

, 2001
Lysophosphatidic acid (LPA) is a bioactive phospholipid controlling numerous cellular responses through the activation of specific G-protein coupled transmembrane receptors.
Simon, Marie-Françoise, Pagès, Céline, Valet, Philippe, Saulnier-Blache, Jean Sébastien   +3 more
core   +2 more sources

Lysophosphatidic Acid Signaling May Initiate Fetal Hydrocephalus

, 2011
Blockade of lysophosphatidic acid signaling provides a new strategy for treating fetal hydrocephalus.
Yun C. Yung, Marcy A. Kingsbury, Kyoko Noguchi, Jerold Chun, Tetsuji Mutoh, Ji Woong Choi, Richard R. Rivera, Mu-En Lin   +7 more
core   +1 more source