Results 121 to 130 of about 24,337 (231)

Lysophosphatidic Acid (LPA) Signaling in Human and Ruminant Reproductive Tract

Mediators of Inflammation, 2014
Lysophosphatidic acid (LPA) through activating its G protein-coupled receptors (LPAR 1–6) exerts diverse cellular effects that in turn influence several physiological processes including reproductive function of the female.
Izabela Wocławek-Potocka, Paulina Rawińska, Ilona Kowalczyk-Zieba, Dorota Boruszewska, Emilia Sinderewicz, Tomasz Waśniewski, Dariusz Jan Skarzynski   +6 more
doaj   +1 more source

Effect of Inhibition of the Lysophosphatidic Acid Receptor 1 on Metastasis and Metastatic Dormancy in Breast Cancer [PDF]

, 2017
Background Previous studies identified the human nonmetastatic gene 23 (NME1, hereafter Nm23-H1) as the first metastasis suppressor gene. An inverse relationship between Nm23-H1 and expression of lysophosphatidic acid receptor 1 gene (LPAR1, also known ...
Albaugh, Mary, Barbier, Maryse, Collins, Joshua W., Horak, Christine E., Liewehr, David J., Marshall, Jean-Claude A., Murone, Maximilien, Nakayama, Joji, Palmieri, Diane, Steeg, Patricia S., Steinberg, Seth M., Vidal-Vanaclocha, Fernando   +11 more
core  

Lysophosphatidic Acid Receptor 3 (LPA3): Signaling and Phosphorylation Sites

International Journal of Molecular Sciences
LPA3 receptors were expressed in TREx HEK 293 cells, and their signaling and phosphorylation were studied. The agonist, lysophosphatidic acid (LPA), increased intracellular calcium and ERK phosphorylation through pertussis toxin-insensitive processes. Phorbol myristate acetate, but not LPA, desensitizes LPA3-mediated calcium signaling. The agonists and
K. Helivier Solís, M. Teresa Romero-Ávila, Ruth Rincón-Heredia, J. Adolfo García-Sáinz   +3 more
openaire   +2 more sources

LPA is a chemorepellent for B16 melanoma cells: action through the cAMP-elevating LPA5 receptor.

PLoS ONE, 2011
Lysophosphatidic acid (LPA), a lipid mediator enriched in serum, stimulates cell migration, proliferation and other functions in many cell types. LPA acts on six known G protein-coupled receptors, termed LPA(1-6), showing both overlapping and distinct ...
Maikel Jongsma, Elisa Matas-Rico, Adrian Rzadkowski, Kees Jalink, Wouter H Moolenaar   +4 more
doaj   +1 more source

Lysophospholipid receptors in neurodegeneration and neuroprotection

Exploration of Neuroprotective Therapy
The central nervous system (CNS) is one of the most complex physiological systems, and treatment of CNS disorders represents an area of major medical need.
Eric Birgbauer
doaj   +1 more source

Interleukin-1β Expression Is Required for Lysophosphatidic Acid-Induced Lymphangiogenesis in Human Umbilical Vein Endothelial Cells

International Journal of Inflammation, 2011
Lysophosphatidic acid (LPA) is a lipid mediator which binds to G-protein-coupled receptors and regulates various cellular responses, including inflammation of endothelial cells.
Chih-Hsin Lin, JenHer Lu, Hsinyu Lee
doaj   +1 more source

Roles of lipid mediators in early pregnancy events

Reproductive Medicine and Biology
Background Early pregnancy events, including embryo implantation, are critical for maintaining a healthy pregnancy and facilitating childbirth. Despite numerous signaling pathways implicated in establishing early pregnancy, a comprehensive understanding ...
Shizu Aikawa, Yasushi Hirota
doaj   +1 more source

Review article

, 2019
In eukaryotic cells, the trans-Golgi network (TGN) serves as a platform for secretory cargo sorting and trafficking. In recent years, it has become evident that a complex network of lipid-lipid and lipid-protein interactions contributes to these key ...
Hausser, A., von Blume, J.
core   +1 more source

Calcium puffs are generic InsP₃-activated elementary calcium signals and are downregulated by prolonged hormonal stimulation to inhibit cellular calcium responses [PDF]

, 2001
Elementary Ca2+ signals, such as "Ca2+ puffs", which arise from the activation of inositol 1,4,5-trisphosphate receptors, are building blocks for local and global Ca2+ signalling.
Berridge, Michael J., Bootman, Martin D., De Smedt, Humbert, de Smet, Patrick, Holmes, Andrew, Lipp, Peter, Missiaen, Ludwig, Parys, Jan B., Thomas, David, Thuring, Jan, Tovey, Stephen C., Young, Kenneth W.   +11 more
core  

Antifibrotic effects of 2-carba cyclic phosphatidic acid (2ccPA) in systemic sclerosis: contribution to the novel treatment. [PDF]

, 2019
HIGUCHI Tomoaki, ICHIMURA Yuki, KATSUMATA Yasuhiro, KAWAGUCHI Yasushi, MASUDA Ikuko, MOROHOSHI Toshiro, NOROSE Takanari, TAKAGI Kae, TOCHIMOTO Akiko, YAMANAKA Hisashi   +9 more
core   +2 more sources