Results 121 to 130 of about 2,989,463 (164)

Identification and characterization of a lysophosphatidic acid receptor.

Molecular Pharmacology, 1994
A specific binding site for 1-[3H]stearoyl-lysophosphatidic acid (stearoyl-LPA) was identified and characterized in membranes prepared from rat brain and Swiss 3T3 fibroblasts. Specific binding of [3H]LPA to these sites was protein dependent, was saturable, reached equilibrium in 15 min, and was displacable by the addition of excess unlabeled LPA ...
F J, Thomson, L, Perkins, D, Ahern, M, Clark   +3 more
openaire   +2 more sources

Neurotransmitter Release from Lysophosphatidic Acid-Stimulated PC12 Cells: Involvement of Lysophosphatidic Acid Receptors

Biochemical and Biophysical Research Communications, 1993
The significance of phospholipase D in metabolic regulation is being recognized. The products of phospholipase D action are phosphatidic acid and lysophosphatidic acid (LPA). Whether these lipid products exert their effect through plasma membrane receptor-mediated mechanism is not yet clear.
S, Shiono, K, Kawamoto, N, Yoshida, T, Kondo, T, Inagami   +4 more
openaire   +2 more sources

The Role of Lysophosphatidic Acid Receptors in Ovarian Cancer: A Minireview

Critical Reviews in Eukaryotic Gene Expression, 2020
Lysophosphatidic acid (LPA) is a bioactive lipid component of ovarian cancer activating factor, which is present at a high concentration in the ascitic fluid and plasma of patients with ovarian cancer. A group of six lysophosphatidic acid receptors (LPARs), LPAR1 through LPAR6, which belong to the G protein-coupled receptor superfamily (GPCR), mediate ...
Ran, Cui, Huimin, Bai, Guangming, Cao, Zhenyu, Zhang   +3 more
openaire   +2 more sources

Characterization of a Receptor Subtype-Selective Lysophosphatidic Acid Mimetic

Molecular Pharmacology, 1998
Despite an intriguing cell biology and the suggestion of a role in pathophysiological responses, the mechanism of action of such lipid phosphoric acid mediators as lysophosphatidic acid (LPA) remains obscure, in part because of an underdeveloped medicinal chemistry.
S B, Hooks, S P, Ragan, D W, Hopper, C W, Hönemann, M E, Durieux, T L, Macdonald, K R, Lynch   +6 more
openaire   +2 more sources

Functional lysophosphatidic acid receptors expressed in Oryzias latipes

Gene, 2014
Lysophosphatidic acid (LPA) signaling is known to play biological and pathophysiological roles in many types of animals. Medaka (Oryzias latipes) is an experimental fish that can be easily maintained, propagated, and analyzed, and whose genome has been completely sequenced. However, there is limited information available regarding medaka LPA receptors.
Yuji, Morimoto, Shoichi, Ishii, Jun-Ichi, Ishibashi, Kazutaka, Katoh, Toshifumi, Tsujiuchi, Nao, Kagawa, Nobuyuki, Fukushima   +6 more
openaire   +2 more sources

Regulation of Lysophosphatidic acid receptor 3

The Journal of Pharmacology and Experimental Therapeutics, 2023
Karina Helivier Solís, Ma. Teresa Romero, J. Adolfo Garcia-Sainz   +2 more
openaire   +1 more source

Lysophosphatidic Acid Receptor

2016
Nobuyuki Fukushima, Tsuyoshi Kado, Toshifumi Tsujiuchi   +2 more
openaire   +1 more source

COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS

2011
SEIDERS THOMAS J, ZHAO LUCY, ARRUDA JEANNIE, WANG BOWEI, STEARNS BRIAN ANDREW, TRUONG YEM PHAM, SCOTT JILL MELISSA, HUTCHINSON JOHN HOWARD, CLARK RYAN, COATE HEATHER RENEE, STOCK NICHOLAS SIMON, VOLKOTS DEBORAH   +11 more
  +17 more sources

Lysophosphatidic acid, a growth factor-like lipid, in the saliva

Journal of Lipid Research, 2002
Akira Tokumura, Takayuki Sugiura, Keizo Waku   +2 more
exaly  

Antagonists of lysophosphatidic acid receptors

2010
HUTCHINSON JOHN HOWARD, SEIDERS THOMAS JON, WANG BOWEI, ARRUDA JEANNIE M, ROPPE JEFFREY ROGER, PARR TIMOTHY   +5 more
openaire   +7 more sources