Results 111 to 120 of about 2,989,463 (164)

Lysophosphatidic acid: mitogen and motility factor

, 2003
LPA (lysophosphatidic acid), the simplest of al glycerophospholipids, is a potent inducer of cell proliferation, migration and survival. It does so by activating its cognate G-protein-coupled receptors, four of which have been identified.
van Leeuwen, F N, Giepmans, B N G, van Meeteren, L A, Moolenaar, W.H., Meeteren, L.A. van, Moolenaar, W H, Leeuwen, F.N. van, Giepmans, B.N., Giepmans, B N G; id_orcid   +8 more
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GABA_{B} Receptors Regulate Chick Retinal Calcium Waves [PDF]

, 2001
Correlated spiking activity and associated Ca²⁺ waves in the developing retina are important in determining the connectivity of the visual system. Here, we show that GABA, via GABA_{B} receptors, regulates the temporal characteristics of Ca²⁺ waves ...
Catsicas, M, Mobbs, P
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Short-chain phosphatidates are subtype-selective antagonists of lysophosphatidic acid receptors. Mol Pharmacol

, 2001
Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are members of the phospholipid growth factor family. A major limitation in the field to date has been a lack of receptor subtype-specific agonists and antagonists.
Gabor Tigyi, Kazuaki Yokoyama, De-An Wang, Daniel L Baker, Abby L Parrill, David J Fischer, Nora Nusser, Tamas Virag, Debra Bautista   +8 more
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Short-chain phosphatidates are subtype-selective antagonists of lysophosphatidic acid receptors

, 2001
Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are members of the phospholipid growth factor family. A major limitation in the field to date has been a lack of receptor subtype-specific agonists and antagonists.
Baker, Daniel L., Parrill, Abby L., Bautista, Debra, Wang, De An, Nusser, Nora, Fischer, David J., Virag, Tamas, Yokoyama, Kazuaki   +7 more
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Investigations on the Molecular Mechanisms of EGFR Signal Transactivation in Human Cancer [PDF]

, 2003
Gschwind, A., Gschwind, Andreas, Gschwind, Andreas Franz   +2 more
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Role of lysophosphatidic acid and its receptors in the kidney

Physiological Genomics, 2017
Lysophosphatidic acid (LPA) is a bioactive phospholipid that can exert diverse biological effects in various diseased states of the kidney by activating at least six cognate G protein-coupled receptors and its complex network of heterotrimeric G proteins.
Frank, Park, Duane D, Miller
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Lysophosphatidic Acid Receptors

Molecular Pharmacology, 2000
Lysophosphatidic acid (LPA) is a simple bioactive phospholipid with diverse physiological actions on many cell types. LPA induces proliferative and/or morphological effects and has been proposed to be involved in biologically important processes including neurogenesis, myelination, angiogenesis, wound healing, and cancer progression.
J J, Contos, I, Ishii, J, Chun
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Lysophosphatidic acid (LPA) and its receptors

Current Opinion in Pharmacology, 2009
Lysophosphatidic acid (LPA), a bioactive phospholipid, and its family of cognate G protein-coupled receptors have demonstrated roles in many biological functions in the nervous system. To date, five LPA receptors have been identified, and additional receptors may exist.
Kyoko, Noguchi, Deron, Herr, Tetsuji, Mutoh, Jerold, Chun   +3 more
openaire   +2 more sources

Lysophosphatidic acid: receptors, signaling and survival

Cellular and Molecular Life Sciences, 2000
Though the mitogenic activity of lysophosphatidic acid (LPA) has been well established through classical studies, its mechanism of action was long obscure. Recent identification and cloning of LPA-specific receptors has led to the elucidation of the G-proteins and signaling pathways through which this molecule functions.
J T, Swarthout, H W, Walling
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The development of modulators for lysophosphatidic acid receptors: A comprehensive review

Bioorganic Chemistry, 2021
Lysophosphatidic acids (LPAs) are bioactive phospholipids implicated in a wide range of cellular activities that regulate a diverse array of biological functions. They recognize two types of G protein-coupled receptors (LPARs): LPA1-3 receptors and LPA4-6 receptors that belong to the endothelial gene (EDG) family and non-endothelial gene family ...
Wenjie, Liu, Austin M, Hopkins, Jinqiang, Hou   +2 more
openaire   +2 more sources