Results 131 to 140 of about 15,272 (178)

GPR35 is a novel lysophosphatidic acid receptor

Biochemical and Biophysical Research Communications, 2010
GPR35 is a rhodopsin-like G protein-coupled receptor identified in 1998. It has been reported that kynurenic acid, a tryptophan metabolite, may act as an endogenous ligand for GPR35. However, the concentrations of kynurenic acid required to elicit the cellular responses are usually high, raising the possibility that another endogenous ligand may exist.
Atsushi Yamashita, Takayuki Sugiura, Saori Oka   +2 more
exaly   +3 more sources

Lysophosphatidic Acid Receptors

Molecular Pharmacology, 2000
Lysophosphatidic acid (LPA) is a simple bioactive phospholipid with diverse physiological actions on many cell types. LPA induces proliferative and/or morphological effects and has been proposed to be involved in biologically important processes including neurogenesis, myelination, angiogenesis, wound healing, and cancer progression.
J J, Contos, I, Ishii, J, Chun
openaire   +2 more sources

Lysophosphatidic acid (LPA) and its receptors

Current Opinion in Pharmacology, 2009
Lysophosphatidic acid (LPA), a bioactive phospholipid, and its family of cognate G protein-coupled receptors have demonstrated roles in many biological functions in the nervous system. To date, five LPA receptors have been identified, and additional receptors may exist.
Kyoko, Noguchi, Deron, Herr, Tetsuji, Mutoh, Jerold, Chun   +3 more
openaire   +2 more sources

Lysophosphatidic acid: receptors, signaling and survival

Cellular and Molecular Life Sciences, 2000
Though the mitogenic activity of lysophosphatidic acid (LPA) has been well established through classical studies, its mechanism of action was long obscure. Recent identification and cloning of LPA-specific receptors has led to the elucidation of the G-proteins and signaling pathways through which this molecule functions.
J T, Swarthout, H W, Walling
openaire   +2 more sources

Role of lysophosphatidic acid and its receptors in the kidney

Physiological Genomics, 2017
Lysophosphatidic acid (LPA) is a bioactive phospholipid that can exert diverse biological effects in various diseased states of the kidney by activating at least six cognate G protein-coupled receptors and its complex network of heterotrimeric G proteins.
Frank, Park, Duane D, Miller
openaire   +2 more sources

Identification and characterization of a lysophosphatidic acid receptor.

Molecular Pharmacology, 1994
A specific binding site for 1-[3H]stearoyl-lysophosphatidic acid (stearoyl-LPA) was identified and characterized in membranes prepared from rat brain and Swiss 3T3 fibroblasts. Specific binding of [3H]LPA to these sites was protein dependent, was saturable, reached equilibrium in 15 min, and was displacable by the addition of excess unlabeled LPA ...
F J, Thomson, L, Perkins, D, Ahern, M, Clark   +3 more
openaire   +2 more sources

Neurotransmitter Release from Lysophosphatidic Acid-Stimulated PC12 Cells: Involvement of Lysophosphatidic Acid Receptors

Biochemical and Biophysical Research Communications, 1993
The significance of phospholipase D in metabolic regulation is being recognized. The products of phospholipase D action are phosphatidic acid and lysophosphatidic acid (LPA). Whether these lipid products exert their effect through plasma membrane receptor-mediated mechanism is not yet clear.
S, Shiono, K, Kawamoto, N, Yoshida, T, Kondo, T, Inagami   +4 more
openaire   +2 more sources

The Role of Lysophosphatidic Acid Receptors in Ovarian Cancer: A Minireview

Critical Reviews in Eukaryotic Gene Expression, 2020
Lysophosphatidic acid (LPA) is a bioactive lipid component of ovarian cancer activating factor, which is present at a high concentration in the ascitic fluid and plasma of patients with ovarian cancer. A group of six lysophosphatidic acid receptors (LPARs), LPAR1 through LPAR6, which belong to the G protein-coupled receptor superfamily (GPCR), mediate ...
Ran, Cui, Huimin, Bai, Guangming, Cao, Zhenyu, Zhang   +3 more
openaire   +2 more sources

Molecular basis for lysophosphatidic acid receptor antagonist selectivity

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002
Recent characterization of lysophosphatidic acid (LPA) receptors has made possible studies elucidating the structure-activity relationships (SAR) for agonist activity at individual receptors. Additionally, the availability of these receptors has allowed the identification of antagonists of LPA-induced effects.
Vineet M, Sardar, Debra L, Bautista, David J, Fischer, Kazuaki, Yokoyama, Nora, Nusser, Tamas, Virag, De-an, Wang, Daniel L, Baker, Gabor, Tigyi, Abby L, Parrill   +9 more
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Stereochemical properties of lysophosphatidic acid receptor activation and metabolism

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002
Ligand recognition by G protein-coupled receptors (GPCR), as well as substrate recognition by enzymes, almost always shows a preference for a naturally occurring enantiomer over the unnatural one. Recognition of lysophosphatidic acid (LPA) by its receptors is an exception, as both the natural L (R) and unnatural D (S) stereoisomers of LPA are equally ...
Kazuaki, Yokoyama, Daniel L, Baker, Tamas, Virag, Karoly, Liliom, Hoe Sup, Byun, Gabor, Tigyi, Robert, Bittman   +6 more
openaire   +2 more sources