Results 91 to 100 of about 2,989,463 (164)

Preventing acute asthmatic symptoms by targeting a neuronal mechanism involving carotid body lysophosphatidic acid receptors

Nature Communications, 2018
Acute bronchoconstriction is the leading cause of asthmatic sudden death following allergen exposure. The authors show that the systemic increase of LPA following inhaled allergen or bradykinin challenge activates the carotid bodies through TRPV1 and LPA-
Nicholas G. Jendzjowsky, Arijit Roy, Nicole O. Barioni, Margaret M. Kelly, Francis H. Y. Green, Christopher N. Wyatt, Richard L. Pye, Luana Tenorio-Lopes, Richard J. A. Wilson   +8 more
doaj   +1 more source

Regulation of silicosis formation by lysophosphatidic acid and its receptors

Experimental Lung Research, 2014
Silicosis is a serious occupational disease characterized by lung fibrosis that is caused by long-term inhalation of silica-containing fine particles. Lysophosphatidic acid (LPA) and LPA1/3 plays a role in lung fibrosis. Until recently, there has been little research investigating the role of LPA and LPA receptors (LPAR) in silica-induced development ...
Cuicui, Cong, Lijun, Mao, Yanlin, Zhang, Zanmei, Zhao, Xixian, Xu, Jinyuan, Zhao   +5 more
openaire   +2 more sources

Pharmacological activation of lysophosphatidic acid receptors regulates erythropoiesis

Scientific Reports, 2016
AbstractLysophosphatidic acid (LPA), a growth factor-like phospholipid, regulates numerous physiological functions, including cell proliferation and differentiation. In a previous study, we have demonstrated that LPA activates erythropoiesis by activating the LPA 3 receptor subtype (LPA3) under erythropoietin (EPO) induction.
Kuan-Hung Lin, Ya-Hsuan Ho, Jui-Chung Chiang, Meng-Wei Li, Shi-Hung Lin, Wei-Min Chen, Chi-Ling Chiang, Yu-Nung Lin, Ya-Jan Yang, Chiung-Nien Chen, Jenher Lu, Chang-Jen Huang, Gabor Tigyi, Chao-Ling Yao, Hsinyu Lee   +14 more
openaire   +2 more sources

Stereochemical properties of lysophosphatidic acid receptor activation and metabolism

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002
Ligand recognition by G protein-coupled receptors (GPCR), as well as substrate recognition by enzymes, almost always shows a preference for a naturally occurring enantiomer over the unnatural one. Recognition of lysophosphatidic acid (LPA) by its receptors is an exception, as both the natural L (R) and unnatural D (S) stereoisomers of LPA are equally ...
Kazuaki, Yokoyama, Daniel L, Baker, Tamas, Virag, Karoly, Liliom, Hoe Sup, Byun, Gabor, Tigyi, Robert, Bittman   +6 more
openaire   +2 more sources

The Bulk of Autotaxin Activity Is Dispensable for Adult Mouse Life.

PLoS ONE, 2015
Autotaxin (ATX, Enpp2) is a secreted lysophospholipase D catalysing the production of lysophosphatidic acid, a pleiotropic growth factor-like lysophospholipid.
Aggeliki Katsifa, Eleanna Kaffe, Nefeli Nikolaidou-Katsaridou, Aris N Economides, Susan Newbigging, Colin McKerlie, Vassilis Aidinis   +6 more
doaj   +1 more source

Lysophosphatidic Acid (LPA) and Its Receptors in Mood Regulation: A Systematic Review of the Molecular Mechanisms and Therapeutic Potential

Mood disorders affect over 300 million individuals worldwide, often characterized by their chronic and refractory nature, posing significant threats to patient life. There has been a notable increase in mood disorders among American adolescents and young
Nan Li, Yanchun Li
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Expression of Lysophosphatidic Acid Receptors and Local Invasiveness and Metastasis in Chinese Pancreatic Cancers

, 2012
Background and Objectives: The present study evaluated the potential role of lysophosphatidic acid receptors (LPARS) in processes leading to local invasiveness and metastasis in Chinese pancreatic carcinoma.
P. Li, Y.L. Gong, J.F. Chen, G.M. Lv, C.J. Tao, M. Hu, X.F. Cao   +6 more
core   +1 more source

Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs [PDF]

, 2012
When it is difficult to develop selective ligands within a family of related G-protein-coupled receptors (GPCRs), chemically engineered receptors activated solely by synthetic ligands (RASSLs) are useful alternatives for probing receptor function. In the
Christiansen, Elisabeth, Tikhonova, I.G., Ulven, T., Hudson, B., Tikhonova, Irina G, Adams, D.R., Grundmann, Manuel, Milligan, Graeme, Hudson, Brian D, Christiansen, E., Kostenis, Evi, Kostenis, E., Adams, David R, Milligan, G., Tikhonova, Irina G; id_orcid, Ulven, Trond, Grundmann, M.   +16 more
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LPA is a chemorepellent for B16 melanoma cells: action through the cAMP-elevating LPA5 receptor.

PLoS ONE, 2011
Lysophosphatidic acid (LPA), a lipid mediator enriched in serum, stimulates cell migration, proliferation and other functions in many cell types. LPA acts on six known G protein-coupled receptors, termed LPA(1-6), showing both overlapping and distinct ...
Maikel Jongsma, Elisa Matas-Rico, Adrian Rzadkowski, Kees Jalink, Wouter H Moolenaar   +4 more
doaj   +1 more source

Diverse Effects of Lysophosphatidic Acid Receptors on Ovarian Cancer Signaling Pathways

, 2019
Lysophosphatidic acid (LPA) is a bioactive phospholipid with mitogenic and growth factor-like activities affecting cell invasion, cancer progression, and resistance. It is produced mainly by autotaxin and acts on six G-protein-coupled receptors, LPAR1-6.
Reich, Reuven, Davidson, Ben, Onallah, Hadil   +2 more
core   +1 more source