Results 91 to 100 of about 2,728,981 (353)
Melatonin Transmits Photoperiodic Signals through the MT1 Melatonin Receptor [PDF]
The Journal of Neuroscience, 2009 Melatonin transmits photoperiodic signals that regulate reproduction. Two melatonin receptors (MT1 and MT2) have been cloned in mammals and additional melatonin binding sites suggested, but the receptor that mediates the effects of melatonin on the photoperiodic gonadal response has not yet been identified. We therefore investigated in mice whether and
Shinobu, Yasuo +3 more
openaire +2 more sources
Endogenous melatonin partial metabolic clearance as a potential endogenous marker of CYP1A2 activity
British Journal of Clinical Pharmacology, EarlyView.Aims Cytochrome P450 1A2 (CYP1A2) exhibits substantial interindividual variability, necessitating appropriate phenotyping strategies for personalized pharmacotherapy. This study evaluated endogenous melatonin partial metabolic clearance (CLm(MEL)), calculated from urinary 6‐hydroxymelatonin (6‐O‐MEL) excretion and plasma melatonin (MEL) exposure, as a ...
Akitomo Yokokawa +5 more
wiley +1 more source
Serotonin, how to find it... [PDF]
, 2013 Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter. Biochemically derived from tryptophan, serotonin is primarily found in the gastrointestinal tract, platelets, and in the central nervous system (CNS) of animals, including humans ...
Crespi, Francesco
core +1 more source
BMEMat, EarlyView.The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang +6 more
wiley +1 more source
Growing Teeth in the Dark: Circadian Rhythmic Tooth Growth Regulated by Melatonin?
Dental Hypotheses, 2011 Introduction: Melatonin is re-leased from the pineal gland and its release is regulated by the light. It is a well-known hormone for circadian rhythm that affects various activities of our body.
Gang Shen +3 more
doaj
Agomelatine is superior to melatonin in pain suppression: An experimental study
Neurological Sciences and Neurophysiology, 2020 Objective: Agomelatine is a synthetic analog of melatonin with selective agonist action on melatonin MT1 and MT2 receptors and antagonistic effect on serotonin 5HT2c receptors. Similar to melatonin, it also has antinociceptive properties.
Ali Okan Yucel +3 more
doaj +1 more source
Melatonin Synthesis and Function: Evolutionary History in Animals and Plants
Frontiers in Endocrinology, 2019 Melatonin is an ancient molecule that can be traced back to the origin of life. Melatonin's initial function was likely that as a free radical scavenger.
Dake Zhao +6 more
semanticscholar +1 more source
PharmVar GeneFocus: CYP1A2—Clinical Impact, Genetic Variation, and Updated Nomenclature
Clinical Pharmacology &Therapeutics, EarlyView.The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP1A2 gene. CYP1A2 plays a crucial role in the biotransformation of several commonly used drugs, including antipsychotics, antidepressants, anxiolytics, and methylxanthines.
Katalin Monostory +13 more
wiley +1 more source
Identification of pathway-biased and deleterious melatonin receptor mutants in autism spectrum disorders and in the general population. [PDF]
PLoS ONE, 2010 Melatonin is a powerful antioxidant and a synchronizer of many physiological processes. Alteration of the melatonin pathway has been reported in circadian disorders, diabetes and autism spectrum disorders (ASD).
Pauline Chaste +21 more
doaj +1 more source
Ambient technology in epilepsy clinical practice
Epilepsia Open, EarlyView.Abstract The utilization of large language model‐based artificial intelligence (AI) in the field of neurology has gained attention as a viable tool to enhance and assist providers with processes ranging from scheduling patients to providing preliminary interpretations of testing results, pending orders, and documenting encounters. Epileptologists could
Haania Kakwan +3 more
wiley +1 more source