Results 71 to 80 of about 2,728,981 (353)
Medycyna Ogólna i Nauki o Zdrowiu, 2022 Introduction and objective Melatonin is the most important compound produced by the pineal gland. Its daily secretion cycle is responsible for the normal rhythm of sleep and wakefulness.
Sara Hmaidan +3 more
doaj +1 more source
Genetic disruption of the core circadian clock impairs hippocampus-dependent memory [PDF]
, 2014 Perturbing the circadian system by electrolytically lesioning the suprachiasmatic nucleus (SCN) or varying the environmental light:dark schedule impairs memory, suggesting that memory depends on the circadian system.
Chen, Xuanmao +4 more
core +2 more sources
Melatonin Receptor Genes in Vertebrates [PDF]
International Journal of Molecular Sciences, 2013 Melatonin receptors are members of the G protein-coupled receptor (GPCR) family. Three genes for melatonin receptors have been cloned. The MT1 (or Mel1a or MTNR1A) and MT2 (or Mel1b or MTNR1B) receptor subtypes are present in humans and other mammals, while an additional melatonin receptor subtype, Mel1c (or MTNR1C), has been identified in fish ...
Di Li +7 more
openaire +3 more sources
Virtual discovery of melatonin receptor ligands to modulate circadian rhythms
Nature, 2020 The neuromodulator melatonin synchronizes circadian rhythms and related physiological functions through the actions of two G-protein-coupled receptors: MT 1 and MT 2 .
Reed M. Stein +17 more
semanticscholar +1 more source
Automating AI Discovery for Biomedicine Through Knowledge Graphs and Large Language Models Agents
Advanced Intelligent Discovery, EarlyView.This work proposes a novel framework that automates biomedical discovery by integrating knowledge graphs with multiagent large language models. A biologically aligned graph exploration strategy identifies hidden pathways between biomedical entities, and specialized agents use this pathway to iteratively design AI predictors and wet‐lab validation ...
Naafey Aamer +3 more
wiley +1 more source
Pharmacological modulation of MRAP2 protein on murine melatonin receptor signaling
Frontiers in EndocrinologyIntroductionMTNR1A and MTNR1B, crucial for regulating circadian rhythms and various physiological processes, have well- established biological significance.
Wenqi Song +12 more
doaj +1 more source
Pineal and cortical melatonin receptors MT1 and MT2 are decreased in Alzheimer’s disease
European Journal of Histochemistry, 2009 The pineal hormone melatonin is involved in physiological transduction of temporal information from the light dark cycle to circadian and seasonal behavioural rhythms, as well as possessing neuroprotective properties.
P Brunner +5 more
doaj +1 more source
Biomaterials Research, 2023 Background Large-dose melatonin treatment in animal experiments was hardly translated into humans, which may explain the dilemma that the protective effects against myocardial injury in animal have been challenged by clinical trials.
Shanjie Wang +13 more
doaj +1 more source
Melatonin Signaling a Key Regulator of Glucose Homeostasis and Energy Metabolism
Frontiers in Endocrinology, 2019 Melatonin, a hormone synthesized by both the pineal gland and retina, functions as an important modulator of a number of physiological functions.
Sharon Owino +5 more
doaj +1 more source
The effect of melatonin on bacterial translocation following ischemia/reperfusion injury in a rat model of superior mesenteric artery occlusion [PDF]
, 2015 Background: Acute mesenteric ischemia is a life-threatening vascular emergency resulting in tissue destruction due to ischemia-reperfusion injury. Melatonin, the primary hormone of the pineal gland, is a powerful scavenger of reactive oxygen species (ROS)
Aydin, B. +7 more
core +2 more sources