PLoS ONEMelatonin, a molecule with diverse biological functions, is ubiquitously present in living organisms. There is significant interest in understanding melatonin signal transduction pathways in humans, particularly due to its critical role in regulating the
Cathryn S D Maienza +2 more
doaj +1 more source
Genetic effects of melatonin receptor genes on chicken reproductive traits
Czech Journal of Animal Science, 2013 The melatonin receptors are G protein-coupled receptors (GPCR) that bind melatonin. Three types of melatonin receptors have been cloned. The MTNR1A (or Mel1A or MT1) and MTNR1B (or Mel1B or MT2) receptor subtypes are present in humans and other mammals ...
D.Y. Li +7 more
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The Effect of Melatonin on Behavioral, Molecular, and Histopathological Changes in Cuprizone Model of Demyelination [PDF]
, 2016 Multiple sclerosis (MS) is an autoimmune, demyelinating disease of the central nervous system. The protective effects of melatonin (MLT) on various neurodegenerative diseases, including MS, have been suggested.
Ghadiri, T. +6 more
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Non-skeletal activities of vitamin d: From physiology to brain pathology [PDF]
, 2019 Vitamin D is a secosteroid hormone regulating the expression of almost 900 genes, and it is involved in the regulation of calcium and phosphate metabolism, immune response, and brain development.
Bruna Lo Sasso +6 more
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Clock genes regulate Ca2+ signaling and mitochondrial bioenergetics to inhibit Sjogren's disease
Arthritis &Rheumatology, Accepted Article.Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjogren's disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA seq, and mitochondrial activity were used to investigate the effects of ...
Viktor R. Drel +12 more
wiley +1 more source
Expression of three GnRH receptors in specific tissues in male and female sea lampreys Petromyzon marinus at three distinct life stages [PDF]
, 2013 Two recently cloned gonadotropin-releasing hormone (GnRH) receptors (lamprey GnRH-R-2 and lamprey GnRH-R-3) along with lamprey (l) GnRH-R-1 were shown to share similar structural features and amino acid motifs common to other vertebrate receptors.
Daukss, Dana M. +3 more
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The hypocretin/orexin antagonist almorexant promotes sleep without impairment of performance in rats. [PDF]
, 2014 The hypocretin receptor (HcrtR) antagonist almorexant (ALM) has potent hypnotic actions but little is known about neurocognitive performance in the presence of ALM.
Kilduff, Thomas S +4 more
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Adverse Childhood Experiences in Autistic and Neurotypical Girls
Autism Research, EarlyView.ABSTRACT Adverse childhood experiences (ACEs) are potentially traumatic, life‐altering events that occur in childhood with long‐term negative physical and/or mental health outcomes. Previous research, while limited and largely focused on males, suggests children with autism spectrum disorder (ASD) are at higher risk of experiencing ACEs than typically ...
Jon Ebert +4 more
wiley +1 more source
A Review of the Role of Melatonin in Irritable Bowel Syndrome [PDF]
, 2014 Irritable bowel syndrome (IBS) is a troubling disease experienced worldwide. The presentation of symptoms varies from patient to patient, and current prescription treatments can be inadequate in resolving symptoms.
Brinn, Nicole R., Gandhi, Mona A.
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Timing as a sexually selected trait: the right mate at the right moment [PDF]
, 2017 Sexual selection favours the expression of traits in one sex that attract members of the opposite sex for mating. The nature of sexually selected traits such as vocalization, colour and ornamentation, their fitness benefits as well as their costs have ...
Buck, C. Loren +7 more
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