Headache: The Journal of Head and Face Pain, EarlyView.
Carlyn Patterson Gentile +3 more
wiley +1 more source
Sleep Deprivation Alters T Cell Dynamics: Melatonin as a Restorative Agent
ABSTRACT Sleep is an essential physiological function regulated by circadian rhythm and homeostatic regulation for emotional and physical health. Conversely, sleep deprivation (SD) is associated with weakened immune system function and overall health, which potentially leads to chronic diseases such as heart disease and diabetes.
Hilal Öztürk +8 more
wiley +1 more source
Melatonin Biosynthesis, Receptors, and the Microbiota-Tryptophan-Melatonin Axis: A Shared Dysbiosis Signature Across Cardiac Arrhythmias, Epilepsy, Malignant Proliferation, and Cognitive Trajectories. [PDF]
Tavartkiladze A +13 more
europepmc +1 more source
Management of Insomnia Complaints by Non‐Sleep Specialist Physicians: A French DELPHI Consensus
ABSTRACT Insomnia is the most prevalent sleep disorder and a major public health concern, affecting chronically up to 19% of the adult population in France. Despite its significant impact on quality of life, mental health, and cardiometabolic disease, insomnia disorder remains underdiagnosed and inadequately managed.
Pierre‐Alexis Geoffroy +6 more
wiley +1 more source
Sleep and Rhythmic Profile After Pineal Gland Removal in Humans
ABSTRACT Melatonin, a hormone produced by the pineal gland, is classically described as a central circadian modulator. However, the impact of its absence on circadian rhythmicity in humans remains poorly understood. Pinealectomised patients, in whom melatonin secretion is chronically suppressed, represent a valuable clinical model to investigate the ...
Renata de Andrade Prado Gobetti +7 more
wiley +1 more source
Suicidal Ideation Following a Single Dose of Melatonin in a Patient With Major Depressive Disorder: A Case Report. [PDF]
Badrfam R, Zandifar A.
europepmc +1 more source
ABSTRACT The 2019 coronavirus (COVID‐19) pandemic and associated lockdowns significantly disrupted healthcare systems, including access to pharmacological treatments such as sleep medication. This study investigated the number of first‐time dispensed hypnotic drugs during the first COVID‐19 lockdown in the Netherlands, using data from the Dutch ...
Dana M. Dijkgraaf +5 more
wiley +1 more source
Unveiling melatonin's multifaceted actions against ferroptotic neurotoxicity in ischemic stroke. [PDF]
Boonmag S, Reiter RJ, Govitrapong P.
europepmc +1 more source
ABSTRACT Problems with initiating and maintaining sleep are among the most common health complaints, with prevalence rates exceeding 50% depending on the survey. Preventing the progression to chronic insomnia may reduce public healthcare costs and prevent secondary illnesses.
Maren‐Jo Kater +3 more
wiley +1 more source
Evaluation of the mechanism underlying melatonin action in cholestatic liver disease treatment via network pharmacology, molecular docking, and in vivo experiments. [PDF]
Li T, ZhenYu J, Jing W.
europepmc +1 more source

