Results 41 to 50 of about 23,013 (268)

Cardiac-targeted delivery of nuclear receptor RORα via ultrasound targeted microbubble destruction optimizes the benefits of regular dose of melatonin on sepsis-induced cardiomyopathy

Biomaterials Research, 2023
Background Large-dose melatonin treatment in animal experiments was hardly translated into humans, which may explain the dilemma that the protective effects against myocardial injury in animal have been challenged by clinical trials.
Shanjie Wang, Kegong Chen, Ye Wang, Zeng Wang, Zhaoying Li, JunChen Guo, Jianfeng Chen, Wenhua Liu, Xiaohui Guo, Guangcan Yan, Chenchen Liang, Huai Yu, Shaohong Fang, Bo Yu   +13 more
doaj   +1 more source

Clinical usefulness of melatonin MT1 and MT2 receptor agonists in the treatment of sleep disorders and depression

Medycyna Ogólna i Nauki o Zdrowiu, 2022
Introduction and objective Melatonin is the most important compound produced by the pineal gland. Its daily secretion cycle is responsible for the normal rhythm of sleep and wakefulness.
Sara Hmaidan, Ewa Gibuła-Tarłowska, Paweł Grochecki, Ewa Kędzierska   +3 more
doaj   +1 more source

Melatonin Receptor Genes in Vertebrates [PDF]

International Journal of Molecular Sciences, 2013
Melatonin receptors are members of the G protein-coupled receptor (GPCR) family. Three genes for melatonin receptors have been cloned. The MT1 (or Mel1a or MTNR1A) and MT2 (or Mel1b or MTNR1B) receptor subtypes are present in humans and other mammals, while an additional melatonin receptor subtype, Mel1c (or MTNR1C), has been identified in fish ...
Di Li, David Smith, Rüdiger Hardeland, Ming Yang, Huai Xu, Long Zhang, Hua Yin, Qing Zhu   +7 more
openaire   +3 more sources

Prevalence and impact of prescribing cascades in community‐dwelling adults: Longitudinal analysis of the Irish longitudinal study on ageing (TILDA)

British Journal of Clinical Pharmacology, EarlyView.
Prescribing cascades occur when medication is prescribed to prevent/treat the adverse effects of another medication and may be intentional/unintentional. This study examines the prevalence of nine prescribing cascades (ThinkCascades) in The Irish Longitudinal StuDy on Ageing (TILDA).
Ann Sinéad Doherty, Rose Anne Kenny, Frank Moriarty, Fiona Boland, Barbara Clyne, Tom Fahey, Denis O' Mahony, Emma Wallace   +7 more
wiley   +1 more source

Melatonin Signaling a Key Regulator of Glucose Homeostasis and Energy Metabolism

Frontiers in Endocrinology, 2019
Melatonin, a hormone synthesized by both the pineal gland and retina, functions as an important modulator of a number of physiological functions.
Sharon Owino, Sharon Owino, Daniella D. C. Buonfiglio, Daniella D. C. Buonfiglio, Cynthia Tchio, Gianluca Tosini   +5 more
doaj   +1 more source

Exosome as bioactive nanovesicle for diagnostic and therapeutic applications in periodontitis

BMEMat, EarlyView.
This review introduces the mechanism that exosomes participate in the pathogenesis of periodontitis and their potential as biomarkers for early diagnosis and summarizes the application of cell‐ or plant‐derived exosomes or engineered exosomes in periodontitis or periodontal regeneration while proposing the perspective of translational application of ...
Yu Wang, Yuchen Li, Yunfan Zhang, Chenshuang Li, Yifan Lin, Si Chen, Bing Han   +6 more
wiley   +1 more source

Cross-species comparison of AlphaFold-derived G protein-coupled receptor structures reveals novel melatonin-related receptor in Neurospora crassa.

PLoS ONE
Melatonin, a molecule with diverse biological functions, is ubiquitously present in living organisms. There is significant interest in understanding melatonin signal transduction pathways in humans, particularly due to its critical role in regulating the
Cathryn S D Maienza, Guillaume Lamoureux, Kwangwon Lee   +2 more
doaj   +1 more source

Genetic effects of melatonin receptor genes on chicken reproductive traits

Czech Journal of Animal Science, 2013
The melatonin receptors are G protein-coupled receptors (GPCR) that bind melatonin. Three types of melatonin receptors have been cloned. The MTNR1A (or Mel1A or MT1) and MTNR1B (or Mel1B or MT2) receptor subtypes are present in humans and other mammals ...
D.Y. Li, L. Zhang, D.G. Smith, H.L. Xu, Y.P. Liu, X.L. Zhao, Y. Wang, Q. Zhu   +7 more
doaj   +1 more source

Timing is everything: Expert opinion on researching epilepsy rhythms by the ILAE Task Force on Chronobiology

Epilepsia, EarlyView.
Abstract Recurrent seizures, the hallmark of epilepsy, are influenced by rhythms operating over multiple timescales. Chronobiology is the study of biological timing that aims to explain temporal patterns of events like seizures. Fueled by recent advances in genetics, computational modeling, and device engineering, the chronobiology of epilepsy is now a
Maxime O. Baud, Christophe Bernard, Birgit Frauscher, Philippa J. Karoly, Vikram R. Rao   +4 more
wiley   +1 more source

Structural insights into melatonin receptors [PDF]

The FEBS Journal, 2019
The long‐anticipated high‐resolution structures of the human melatonin G protein‐coupled receptors MT1 and MT2, involved in establishing and maintaining circadian rhythm, were obtained in complex with two melatonin analogs and two approved anti‐insomnia and antidepression drugs using X‐ray free‐electron laser serial femtosecond crystallography.
Benjamin Stauch, Linda C. Johansson, Vadim Cherezov   +2 more
openaire   +2 more sources