Results 211 to 220 of about 126,867 (267)

Metabotropic glutamate receptors and epilepsy

Journal of the Neurological Sciences, 2006
Metabotropic glutamate receptors (mGluRs) play an important role in the initiation of ictal discharges by participating in the interictal-ictal transition, and may play a crucial role in recruiting normal brain tissue into synchronized discharges, thereby facilitating propagation of seizure activity.
Jorge, Ure, Michel, Baudry, Mónica, Perassolo   +2 more
openaire   +2 more sources

Estrogen receptor signaling through metabotropic glutamate receptors

2020
As the non-nuclear initiated effects of steroid hormone signaling have become more widely accepted, there has been a need to define the novel mechanisms of hormone receptor action that account for these outcomes. One mechanism that has emerged is the coupling of classical estrogen receptors (ERα and ERβ) with metabotropic glutamate receptors (mGluRs ...
Kellie S, Gross, Paul G, Mermelstein
openaire   +2 more sources

Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system.

Journal of Pharmacology and Experimental Therapeutics, 2001
Metabotropic glutamate (mGlu) receptors, which include mGlu1-8 receptors, are a heterogeneous family of G-protein-coupled receptors which function to modulate brain excitability via presynaptic, postsynaptic and glial mechanisms.
D. Schoepp
semanticscholar   +1 more source

Metabotropic Glutamate Receptors and Neuronal Toxicity

1992
Specific glutamate receptors coupled to polyphosphoinositide (PPI) hydrolysis have been described in brain slices, cultured neurons, and astrocytes, and in amphibian oocytes injected with rat brain mRNA (Sladeczek et al., 1985; Nicoletti et al., 1986a,b; Sugiyama et al., 1987).
ALEPPO G, PISANI A, COPANI A, BRUNO V, ARONICA E, D'AGATA V, CANONICO P. L, NICOLETTI F   +7 more
openaire   +6 more sources

Metabotropic Glutamate Receptors and Neurodegeneration

2004
Metabotropic glutamate (mGlu) receptors, which exert a modulatory effect on excitatory synaptic transmission, are considered as potential targets for neuroprotective drugs and the advent of potent and centrally available subtype-selective ligands has lead to an extensive investigation of the role of individual mGlu receptor subtypes in ...
BRUNO, Valeria Maria Gloria, BATTAGLIA, Giuseppe, NICOLETTI, Ferdinando   +2 more
openaire   +2 more sources

Receptors | Glutamate Receptors, Metabotropic

2021
Karen J. Gregory, P. Jeffrey Conn, Jason E. Schaffer   +2 more
openaire   +1 more source

Pharmacology and functions of metabotropic glutamate receptors.

Annual Review of Pharmacology and Toxicology, 1997
Conn Pj, J. Pin
semanticscholar   +1 more source

Metabotropic glutamate receptors and neurodegeneration.

Progress in brain research, 1998
Metabotropic glutamate (mGlu) receptors belong to a class of G-protein linked receptors, which also includes the Ca2+-sensing receptor and the gama-aminobutyric acid (GABAB) receptor. A great variety of drugs has been introduced with the intent of limiting some of the intracellular events that occur downstream of the increase in intracellular Ca2 ...
BRUNO, Valeria Maria Gloria, BATTAGLIA, Giuseppe, A. Copani, G. Casabona, M. Storto, V. D. Giorgi, R. Ngomba, NICOLETTI, Ferdinando   +7 more
openaire   +3 more sources

The metabotropic glutamate receptors: structure and functions.

Neuropharmacology, 1995
J. Pin, R. Duvoisin
semanticscholar   +1 more source

Metabotropic glutamate receptors and neurodegenerative diseases.

Pharmacological Research, 2017
F. M. Ribeiro, L. Vieira, R. Pires, R. P. Olmo, S. Ferguson   +4 more
semanticscholar   +1 more source