Results 151 to 160 of about 31,219 (282)
Obesity Reviews, EarlyView.ABSTRACT Introduction Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RA) improve outcomes in heart failure (HF) with preserved ejection fraction. Whether GLP‐1 RA prevent new‐onset HF in Type 2 diabetes or obesity requires further investigation. Methods We performed an updated meta‐analysis of randomized placebo‐controlled trials (RCT) of treatment ...
João Sérgio Neves +8 more
wiley +1 more source
Impact of diet and exercise in growth restricted female rats on nephron endowment in male fetuses
Experimental Physiology, EarlyView.Abstract Uteroplacental insufficiency impairs kidney development and programs male‐onset cardiorenal disease, which can be transmitted to subsequent generations. Maternal lifestyle factors can independently influence fetal kidney development, highlighting that the lifestyle of growth‐restricted females can have further influence on F2 kidney ...
Jessica F. Briffa +11 more
wiley +1 more source
Ouabain‐induced hypertension in rats: Mechanisms, variability and translational implications
Experimental Physiology, EarlyView.Abstract Ouabain‐induced hypertension is a multifactorial and condition‐dependent phenomenon involving coordinated actions across vascular, renal and central nervous system pathways. At the vascular level, ouabain inhibits Na⁺/K⁺‐ATPase, particularly the α2‐isoform, leading to elevated intracellular Ca2⁺, enhanced vasoconstriction and structural ...
Priscilla Rodrigues O. Feijó +1 more
wiley +1 more source
Experimental Physiology, EarlyView.Abstract Menopause increases the risk of hypertension in women, yet the factors contributing to this important change remain unclear. Because early life stress has persistent and sex‐specific consequences on health, we hypothesized that ageing reveals the latent effects of neonatal maternal separation (NMS) on cardiovascular homeostasis in female rats.
Danuzia Ambrozio‐Marques +6 more
wiley +1 more source
DEN Open, Volume 6, Issue 1, April 2026.ABSTRACT Endoscopic submucosal dissection (ESD) is widely used for early esophageal cancer, even in patients with liver cirrhosis (LC). Corticosteroids, administered orally or by local injection, are often used to prevent post‐ESD esophageal stricture. However, their safety in patients with decompensated LC and refractory ascites remains unclear. A man
Yuki Tamura +9 more
wiley +1 more source
Developmental Psychobiology, Volume 68, Issue 2, March 2026.ABSTRACT Weaning is a stressful stage in the lives of young mammals. Early weaning, in particular, can lead to long‐lasting physiological and psychological changes. We investigated the effects of precocial weaning on anxiety, social behavior, cognition, and maternal behavior in adult African four‐striped mice (Rhabdomys dilectus chakae). Mice weaned at
Maria K Oosthuizen, Neville Pillay
wiley +1 more source
Regulation of Klotho Production by Mineralocorticoid Receptor Signaling in Renal Cell Lines. [PDF]
BiomoleculesKohm E, Feger M, Föller M.
europepmc +1 more source
Food Frontiers, Volume 7, Issue 2, March 2026.Cardamonin upregulate sd the intestinal metabolite columbianetin acetate, which competitively bound HMGB1 to prevent LPS‐induced renal tubular cell pyroptosis (the figure is created with BioRender). ABSTRACT Sepsis‐associated acute kidney injury (SA‐AKI) results in high mortality due to the lack of effective interventions. The current study reports the
Zihui Zhou +6 more
wiley +1 more source
ClC‐2 Contributes to Hypotonicity‐Induced Adrenal Aldosterone Secretion
Acta Physiologica, Volume 242, Issue 3, March 2026.ABSTRACT Aim The zona glomerulosa (ZG) of the adrenal cortex regulates blood pressure and electrolyte homeostasis through aldosterone production. In ZG cells, potassium and angiotensin II (Ang II) trigger calcium oscillations that drive aldosterone synthesis.
Marina Volkert +3 more
wiley +1 more source