Results 11 to 20 of about 2,325,434 (292)

Mineralocorticoid receptors in the pathophysiology of vascular inflammation and atherosclerosis.

Frontiers in Endocrinology, 2015
Atherosclerosis is a chronic inflammatory disease of the vasculature that causes significant morbidity and mortality from myocardial infarction, stroke, peripheral vascular disease, and heart failure.
Mary Elizabeth Moss, Mary Elizabeth Moss, Iris Z Jaffe, Iris Z Jaffe   +3 more
doaj   +2 more sources

Distinct regulation of hippocampal neuroplasticity and ciliary genes by corticosteroid receptors

Nature Communications, 2021
Glucocorticoid hormones (GCs) are of critical importance for maintaining brain health, but their involvement in mental disorders is poorly understood. Here the authors show how GCs act through hippocampal mineralocorticoid and glucocorticoid receptors to
Karen R. Mifsud, Clare L. M. Kennedy, Silvia Salatino, Eshita Sharma, Emily M. Price, Samantha N. Haque, Andriana Gialeli, Hannah M. Goss, Polina E. Panchenko, John Broxholme, Simon Engledow, Helen Lockstone, Oscar Cordero Llana, Johannes M. H. M. Reul   +13 more
doaj   +1 more source

Aldosterone Blocks Rat Stem Leydig Cell Development In Vitro

Frontiers in Endocrinology, 2018
Aldosterone (ALDO) is a primary endogenous mineralocorticoid, appearing as the main hormone controlling sodium and water homeostasis. Its emerging role in the development of many organs has gained interest over the past few years.
Jingwei Zhang, Bisheng Huang, Guanghui Hu, Xiangcheng Zhan, Tiancheng Xie, Saiyang Li, Xiaolu Zhang, Huitao Li, Ren-Shan Ge, Yunfei Xu   +9 more
doaj   +1 more source

Glucocorticoid and Mineralocorticoid Receptors in the Brain: A Transcriptional Perspective

Journal of the Endocrine Society, 2019
Adrenal glucocorticoid hormones are crucial for maintenance of homeostasis and adaptation to stress. They act via the mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs)—members of the family of nuclear receptors. MRs and GRs can mediate
Anne M. Koning, Jacobus C. Buurstede, Lisa T C M van Weert, O. Meijer   +3 more
semanticscholar   +1 more source

Cardiomyocyte glucocorticoid and mineralocorticoid receptors directly and antagonistically regulate heart disease in mice

Science Signaling, 2019
Skewing glucocorticoid signaling to favor mineralocorticoid receptor activation is detrimental to the heart. A balancing act for the heart Stress increases the risk of dying from cardiometabolic disease.
R. Oakley, D. Cruz-Topete, Bo He, J. Foley, P. Myers, Xiaojiang Xu, C. Gomez-Sanchez, P. Chambon, M. Willis, J. Cidlowski   +9 more
semanticscholar   +1 more source

Structural and molecular determinants of mineralocorticoid receptor signalling

British Journal of Pharmacology, 2021
During the past decades, the mineralocorticoid receptor (MR) has evolved from a much‐overlooked member of the steroid hormone receptor family to an important player, not only in volume and electrolyte homeostasis but also in pathological changes ...
C. Grossmann, Brian Almeida-Prieto, Alexander Nolze, D. Álvarez de la Rosa   +3 more
semanticscholar   +1 more source

Evolution of ligand specificity in vertebrate corticosteroid receptors

BMC Evolutionary Biology, 2011
Background Corticosteroid receptors include mineralocorticoid (MR) and glucocorticoid (GR) receptors. Teleost fishes have a single MR and duplicate GRs that show variable sensitivities to mineralocorticoids and glucocorticoids.
Deitcher David L, Mayberry John, Fogarty Elizabeth A, Fergus Daniel J, Arterbery Adam S, Lee Kraus W, Bass Andrew H   +6 more
doaj   +1 more source

Mineralocorticoid receptors guide spatial and stimulus-response learning in mice. [PDF]

PLoS ONE, 2014
Adrenal corticosteroid hormones act via mineralocorticoid (MR) and glucocorticoid receptors (GR) in the brain, influencing learning and memory. MRs have been implicated in the initial behavioral response in novel situations, which includes behavioral ...
J Marit Arp, Judith P ter Horst, Sofia Kanatsou, Guillén Fernández, Marian Joëls, Harm J Krugers, Melly S Oitzl   +6 more
doaj   +1 more source

Novel role for mineralocorticoid receptors in control of a neuronal phenotype

Molecular Psychiatry, 2019
Mineralocorticoid receptors (MRs) in the brain play a role in learning and memory, neuronal differentiation, and regulation of the stress response. Within the hippocampus, the highest expression of MRs is in area CA2.
Katharine E. McCann, D. Lustberg, E. Shaughnessy, K. Carstens, S. Farris, G. M. Alexander, Daniel Radzicki, Meilan Zhao, S. Dudek   +8 more
semanticscholar   +1 more source

Crystal structure of the mineralocorticoid receptor DNA binding domain in complex with DNA.

PLoS ONE, 2014
The steroid hormone receptors regulate important physiological functions such as reproduction, metabolism, immunity, and electrolyte balance. Mutations within steroid receptors result in endocrine disorders and can often drive cancer formation and ...
William H Hudson, Christine Youn, Eric A Ortlund   +2 more
doaj   +1 more source