The Promiscuous Mineralocorticoid Receptor [PDF]
Hypertension, 2016 See related article, pp 897–905 The article by Briet et al1 in this issue, “Aldosterone-induced vascular remodeling and endothelial dysfunction require functional angiotensin type 1a receptors,” represents a prodigious amount of work by the authors: it is not surprising that the first 3 are credited as having equally contributed. The authors build on
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Treatment of Hypertension in a Child With 11Beta-Hydroxylase Deficiency: A Case Report
Journal of Pediatrics Review, 2022 Background: 11beta-hydroxylase deficiency (11βOHD) is clinically presented with external genitalia virilization in girls and precocious puberty in boys. Low renin hypertension occurs in both sexes.
Fatemeh Saffari, Banafsheh Arad
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Mineralocorticoid receptors in the pathophysiology of vascular inflammation and atherosclerosis.
Frontiers in Endocrinology, 2015 Atherosclerosis is a chronic inflammatory disease of the vasculature that causes significant morbidity and mortality from myocardial infarction, stroke, peripheral vascular disease, and heart failure.
Mary Elizabeth Moss +3 more
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Aldosterone status associates with insulin resistance in patients with heart failure-data from the ALOFT study [PDF]
, 2009 <b>Background</b>: Aldosterone plays a key role in the pathophysiology of heart failure. In around 50% of such patients, aldosterone 'escapes' from inhibition by drugs that interrupt the renin-angiotensin axis; such patients have a worse ...
Connell, J.M.C. +8 more
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Glucocorticoid feedback paradox: a homage to Mary Dallman
Stress, 2023 As the end product of the hypothalamus-pituitary-adrenal (HPA) axis, the glucocorticoid hormones cortisol and corticosterone coordinate circadian activities, stress-coping, and adaptation to change.
Edo Ronald de Kloet
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The melanocortin receptors and their accessory proteins. [PDF]
, 2013 The five melanocortin receptors (MCRs) named MC1R-MC5R have diverse physiological roles encompassing pigmentation, steroidogenesis, energy homeostasis and feeding behavior as well as exocrine function.
Chan, LF +3 more
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Stress-induced enhancement of mouse amygdalar synaptic plasticity depends on glucocorticoid and ß-adrenergic activity. [PDF]
PLoS ONE, 2012 BACKGROUND: Glucocorticoid hormones, in interaction with noradrenaline, enable the consolidation of emotionally arousing and stressful experiences in rodents and humans.
Ratna Angela Sarabdjitsingh +4 more
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Origin and diversification of steroids: Co-evolution of enzymes and nuclear receptors [PDF]
, 2010 Recent sequencing of amphioxus and sea urchin genomes has provided important data for understanding the origins of enzymes that synthesize adrenal and sex steroids and the receptors that mediate physiological response to these vertebrate steroids ...
Michael E. Baker
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Mineralocorticoid Receptor Antagonists in ESKD [PDF]
Clinical Journal of the American Society of Nephrology, 2020 There is an urgent need for interventions that reduce cardiovascular risks in patients with ESKD. Recently there has been considerable interest in whether blocking the effects of the mineralocorticoid aldosterone could be such an intervention.
Adhish, Agarwal, Alfred K, Cheung
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Pseudohypoaldosteronism in a newborn male with functional polymorphisms in the mineralocorticoid receptor genes [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2015 Hyponatremia and hyperkalemia in infancy can be attributed to various causes, originating from a variety of renal and genetic disorders. Pseudohypoaldosteronism type 1 (PHA1) is one of these disorders, causing mineralocorticoid resistance that results in
Hyun Ah Jeong +6 more
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