Results 61 to 70 of about 31,255 (208)

Mineralocorticoid Receptor and Cardiovascular Disease [PDF]

American Journal of Hypertension, 2018
AbstractActivation of the mineralocorticoid receptor (MR) in the distal nephron by its ligand, aldosterone, plays an important role in sodium reabsorption and blood pressure regulation. However, expression of the MR goes beyond the kidney. It is expressed in a variety of other tissues in which its activation could lead to tissue injury.
Mathieu, Buonafine, Benjamin, Bonnard, Frédéric, Jaisser   +2 more
openaire   +2 more sources

MINERALOCORTICOID RECEPTOR ANTAGONISTS THERAPY IN RESISTANT HYPERTENSION: TIME TO IMPLEMENT NEW GUIDELINES?

Frontiers in Cardiovascular Medicine, 2015
Despite the availability of anti-hypertensive medications with increasing efficacy up to 50% of hypertensive patients have blood pressure levels (BP) not at the goals set by international societies.
Giuseppe eMaiolino, Matteo eAzzolini, Gian Paolo eRossi   +2 more
doaj   +1 more source

Exclusion of the Locus for Autosomal Recessive Pseudohypoaldosteronism Type 1 from the Mineralocorticoid Receptor Gene Region on Human Chromosome 4q by Linkage Analysis. [PDF]

, 1995
Pseudohypoaldosteronism type 1 (PHA1) is an uncommon inherited disorder characterized by salt-wasting in infancy arising from target organ unresponsiveness to mineralocorticoids.
Bistritzer, T., Chung, E., Dillon, M., Gardiner, R.M., Hanukoglu, A., Hanukoglu, I., Kuhnle, U., Rees, M., Seckl, J., Thompson, R.   +9 more
core   +1 more source

Aldosterone Synthase Inhibitors for Cardiorenal Protection: Ready for Prime Time?

Kidney & Blood Pressure Research
Background: Aldosterone is the principal mineralocorticoid hormone and the final effector of the renin-angiotensin-aldosterone system. This hormone is primarily synthesized by the CYP11B2 enzyme and produced by the adrenal zona glomerulosa ...
Alessio Mazzieri, Francesca Timio, Francesco Patera, Francesco Trepiccione, Mario Bonomini, Gianpaolo Reboldi   +5 more
doaj   +1 more source

Natural and Synthetic Corticosteroids Inhibit Uptake\u3csub\u3e2\u3c/sub\u3e-Mediated Transport in CNS Neurons [PDF]

, 2011
In addition to exerting actions via mineralocorticoid and glucocorticoid receptors, corticosteroids also act by inhibiting uptake2, a high-capacity monoamine transport system originally described in peripheral tissues.
Gasser, Paul J., Hill, Jonathan E., Hillard, Cecilia J., Makky, Khadijah, Shrestha, Lalita   +4 more
core   +1 more source

Disruption of Glucocorticoid and Mineralocorticoid Receptor-Mediated Responses by Environmental Chemicals

CHIMIA, 2008
Glucocorticoids and mineralocorticoids are key endocrine hormones modulating essential physiological processes such as energy metabolism, cell growth and differentiation, maintenance of blood pressure and immune responses.
Alex Odermatt, Christel Gumy
doaj   +1 more source

Role of 11β-hydroxysteroid dehydrogenase 2 renal activity in potassium homeostasis in rats with chronic renal failure [PDF]

, 2010
Aldosterone concentrations vary in advanced chronic renal failure (CRF). The isozyme 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2), which confers aldosterone specificity for mineralocorticoid receptors in distal tubules and collecting ducts, has been ...
Altuna, Maria Eugenia, Damasco, Maria Cristina, Mac Laughlin, Myriam Alicia, Yeyati, Nesmo   +3 more
core   +1 more source

Campylobacter concisus Impairs Sodium Absorption in Colonic Epithelium via ENaC Dysfunction and Claudin-8 Disruption [PDF]

, 2020
The epithelial sodium channel (ENaC) can increase the colonic absorptive capacity for salt and water. Campylobacter concisus is a common pathogenic epsilonproteobacterium, causing enteritis and diarrhea. It can induce barrier dysfunction in the intestine,
Bereswill, Stefan, Butkevych, Eduard, Bücker, Roland, Fromm, Anja, Genger, Claudia, Heimesaat, Markus M., Kløve, Sigri, Lee, In-Fah Maria, Lobo de Sá, Fábia Daniela, Mousavi, Soraya, Nagel, Oliver, Nattramilarasu, Praveen Kumar, Nielsen, Hans Linde, Schulzke, Jörg-Dieter, Schweiger, Michal R., Troeger, Hanno   +15 more
core   +2 more sources

Evidence for Aldosterone Antagonism in Heart Failure

Cardiac Failure Review
Activation of the renin–angiotensin–aldosterone system is the ultimate pathophysiological hallmark in heart failure. Though aldosterone primarily appears to regulate electrolyte homeostasis by acting on distal nephrons in the kidneys, its effects are far-
Rishi Sethi, Pravesh Vishwakarma, Akshyaya Pradhan   +2 more
doaj   +1 more source

Therapeutic Potential of Mineralocorticoid Receptors in Skeletal Muscle Aging

Receptors
Skeletal muscle aging, or sarcopenia, involves progressive muscle mass and function loss, which limits mobility and independence in elderly populations.
Ricardo Aparecido Baptista Nucci, Otávio de Toledo Nóbrega, Wilson Jacob-Filho   +2 more
doaj   +1 more source