Results 71 to 80 of about 31,255 (208)
Glucocorticoid-Induced Leucine Zipper in Central Nervous System Health and Disease [PDF]
, 2016 The central nervous system (CNS) is a large network of intercommunicating cells that function to maintain tissue health and homeostasis. Considerable evidence suggests that glucocorticoids exert both neuroprotective and neurodegenerative effects on the ...
Lahiri, Debomoy K., Srinivasan, Mythily
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Epidermal mineralocorticoid receptor plays beneficial and adverse effects in skin and mediates glucocorticoid responses [PDF]
, 2016 10 páginas, 6 figuras. Contiene material suplementarioGlucocorticoids (GCs) regulate skin homeostasis and combat cutaneous inflammatory diseases; however, adverse effects of chronic GC treatments limit their therapeutic use.
Boix, Julia +4 more
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Endocrinologic Control of Men's Sexual Desire and Arousal/Erection [PDF]
, 2016 Several hormones and neurotransmitters orchestrate men's sexual response, including the appetitive (sexual desire) and consummative (arousal and penile erection) phases.
Aversa, Antonio +4 more
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Journal of Pharmacological Sciences, 2011 Mineralocorticoid receptor (MR) antagonists, such as spironolactone (SPI) and eplerenone (EPL), are useful for the treatment of hypertension and heart failure.
Tetsuro Nariai +5 more
doaj +1 more source
Genomic and non-genomic effects of mineralocorticoid receptors and glucocorticoid receptors and their roles of pain modulation [PDF]
, 2018 Corticosteroids, including mineralocorticoids and glucocorticoids, are best known for their effective relief of inflammation and pain through activation of the intracellular mineralocorticoid (MR) and glucocorticoid receptors (GR) that changes gene ...
Li, Xiongjuan
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Brazilian Journal of Medical and Biological Research, 2007 Central angiotensin II (AngII) stimulates water and salt solution intake. Pretreatment with low-dose mineralocorticoid (DOCA) enhances this AngII-induced intake of salt solutions (the synergy theory) in Wistar and Sprague Dawley rats but not in Fischer ...
S.N. Thornton +2 more
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Vamorolone targets dual nuclear receptors to treat inflammation and dystrophic cardiomyopathy
Life Science Alliance, 2019 Vamorolone is a first-in-class dissociative drug that selectively targets the glucocorticoid receptor to safely treat chronic inflammation and the mineralocorticoid receptor to treat cardiomyopathy, providing efficacy with improved safety in mouse models
Christopher R Heier +11 more
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Adipocytes, aldosterone and obesity-related hypertension [PDF]
, 2016 Understanding the mechanisms linking obesity with hypertension is important in the current obesity epidemic as it may improve therapeutic interventions.
Friederich-Persson, Malou +3 more
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Immune Effects of Corticosteroids in Sepsis
Frontiers in Immunology, 2018 Sepsis, a life-threatening organ dysfunction, results from a dysregulated host response to invading pathogens that may be characterized by overwhelming systemic inflammation or some sort of immune paralysis.
Nicholas Heming +6 more
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Eplerenone reduces lymphangiogenesis in the contralateral kidneys of UUO rats
Scientific ReportsInflammation and fibrosis often occur in the kidney after acute injury, resulting in chronic kidney disease and consequent renal failure. Recent studies have indicated that lymphangiogenesis can drive renal inflammation and fibrosis in injured kidneys ...
Juan Hao +9 more
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