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Interdomain interactions in the mineralocorticoid receptor
Molecular and Cellular Endocrinology, 2003The potential for interaction between the N-terminal domain and the C-terminal region (hinge and ligand-binding domain) of the mineralocorticoid receptor (MR) was examined using the mammalian-2-hybrid assay. The MR C-terminal region was fused to the GAL4 DNA-binding domain (GAL4-MRC).
Fraser M, Rogerson, Peter J, Fuller
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Nihon rinsho. Japanese journal of clinical medicine, 2009
Recent clinical trials have indicated the utility of mineralocorticoid receptor (MR) antagonists in patients with cardiovascular and renal diseases. Experiments studies have shown that chronic treatment with aldosterone resulted in severe cardiac and renal injuries, which were ameliorated by MR antagonists.
Akira, Nishiyama +2 more
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Recent clinical trials have indicated the utility of mineralocorticoid receptor (MR) antagonists in patients with cardiovascular and renal diseases. Experiments studies have shown that chronic treatment with aldosterone resulted in severe cardiac and renal injuries, which were ameliorated by MR antagonists.
Akira, Nishiyama +2 more
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Novel interactions of the mineralocorticoid receptor
Molecular and Cellular Endocrinology, 2015The mineralocorticoid receptor (MR) differs from the other steroid receptors in that it responds to two physiological ligands, aldosterone and cortisol. In epithelial tissues, aldosterone selectivity is determined by 11β-hydroxysteroid dehydrogenase type II.
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Mechanisms of Mineralocorticoid Receptor Signaling
2019The cellular response to aldosterone is mediated by the mineralocorticoid receptor (MR). This response is best characterized in the renal epithelia with control of sodium and water homeostasis. However, the MR binds more than one ligand and has wide tissue distribution with multiple roles in cardiovascular function, immune cell signaling, neuronal fate
Peter J, Fuller +2 more
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Cyproheptadine and Mineralocorticoid Receptors
New England Journal of Medicine, 1982ARMANINI, DECIO, KARBOWIAK I, FUNDER J.
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Reconsidering the Roles of the Mineralocorticoid Receptor
Hypertension, 2009Translational research is usually taken to mean the application of laboratory discovery to clinical practice. Like languages or enzymes, however, translation is a 2-way street, and in the field of aldosterone and mineralocorticoid receptors (MR), there are a number of examples where clinical studies have prompted reconsideration of the basic biology ...
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The role of mineralocorticoid receptor activation in kidney inflammation and fibrosis
Kidney International Supplements, 2022Luther Jm, Agnes Fogo
exaly
Nonepithelial mineralocorticoid receptor activation as a determinant of kidney disease
Kidney International Supplements, 2022Frédéric Jaisser +2 more
exaly