Results 121 to 130 of about 2,302,872 (259)

Test–retest reliability of Doppler ultrasound‐based leg blood flow assessments during exercise in patients with chronic obstructive pulmonary disease

Experimental Physiology, EarlyView.
Abstract Doppler ultrasound may be used to assess leg blood flow (Q̇leg${{\dot{Q}}_{{\mathrm{leg}}}}$), but the reliability of this method remains unexplored in patients with chronic obstructive pulmonary disease (COPD), where between‐subject variability may be larger than healthy due to peripheral vascular changes.
Milan Mohammad, Jacob P. Hartmann, Amalie B. Andersen, Helene L. Hartmeyer, Ulrik W. Iepsen, Ronan M. G. Berg   +5 more
wiley   +1 more source

Methacholine hyperresponsiveness in mice with house dust mite‐induced lung inflammation is not associated with excessive airway constriction ex vivo

Experimental Physiology, EarlyView.
Abstract The role of excessive airway constriction in the hyperresponsiveness to nebulized methacholine in mice with experimental asthma is still contentious. Yet, there have been very few studies investigating whether the increased in vivo response to methacholine caused by experimental asthma is associated with a corresponding increase in ex vivo ...
Andrés Rojas‐Ruiz, Magali Boucher, Cyndi Henry, Louis Gélinas, Rosalie Packwood, Percival Graham, Jorge Soliz, Ynuk Bossé   +7 more
wiley   +1 more source

Endothelial TRPV4–Cx43 signalling complex regulates vasomotor tone in resistance arteries

The Journal of Physiology, EarlyView.
Abstract figure legend In this study, we investigate, for the first time, the role of endothelial Cx43 hemichannels (hCx43) in the regulation of vasomotor tone. We discovered that TRPV4 channels and Cx43 are in proximity within the endothelium of mouse arterioles.
Pía C. Burboa, Pablo S. Gaete, Ping Shu, Priscila A. Araujo, Annie V. Beuve, Walter N. Durán, Jorge E. Contreras, Mauricio A. Lillo   +7 more
wiley   +1 more source

Absence of Functional Autoantibodies Targeting Angiotensin II Receptor Type 1 and Endothelin‐1 Type A Receptor in Circulation and Purified IgG From Patients With Systemic Sclerosis

Arthritis &Rheumatology, Volume 77, Issue 7, Page 901-913, July 2025.
Objective Systemic sclerosis (SSc) is a rare but severe autoimmune disease characterized by immune dysregulation, fibrosis, and vasculopathy. Although previous studies have highlighted the presence of functional autoantibodies targeting the angiotensin II receptor type 1 (AT1) and endothelin‐1 type A receptor (ETAR), leading to autoantibody‐mediated ...
Wieke M. van Oostveen, Eva M. Hoekstra, E. W. Nivine Levarht, Ilana B. Kotliar, Thomas P. Sakmar, René E. M. Toes, Jeska K. de Vries‐Bouwstra, Laura H. Heitman, Cynthia M. Fehres   +8 more
wiley   +1 more source

Neuron‐Derived Extracellular Vesicles: Emerging Biomarkers and Functional Mediators in Alzheimer's Disease, With Comparative Insights Into Neurodevelopment and Aging

Developmental Neurobiology, Volume 85, Issue 3, July 2025.
ABSTRACT Alzheimer's disease (AD) is one of the most common neurodegenerative disorders characterized by the accumulation of amyloid‐β (Aβ) peptide and phosphorylated tau protein in the brain. Despite intensive efforts, early diagnosis and monitoring of AD remain challenging due to the lack of reliable biomarkers that can detect the disease in its ...
Ceren Perihan Gonul, Bilge Karacicek, Sermin Genc   +2 more
wiley   +1 more source

Combined Effects of Intermittent Hypoxia and Amyloid Beta on Hippocampal Activity, Its Cholinergic Modulation, and Memory

Hippocampus, Volume 35, Issue 4, July 2025.
ABSTRACT Obstructive sleep apnea (OSA), characterized by repetitive upper airway obstruction, leads to chronic intermittent hypoxia (cIH) and induces cognitive and neuronal network disruptions similar to those observed in Alzheimer's disease (AD). These pathologies are often presented together in the elderly and share some pathophysiological mechanisms.
Laura Pinedo‐Vargas, Felipe Mendez‐Salcido, Jonathan‐Julio Lorea‐Hernández, Victor de Lafuente, Fernando Peña‐Ortega   +4 more
wiley   +1 more source

Muscarinic Receptor Subtypes Mediating Positive and Negative Inotropy in the Developing Chick Ventricle

Journal of Pharmacological Sciences, 2007
The inotropic response to muscarinic receptor stimulation of isolated chick ventricular myocardium was examined at various developmental stages, and the receptor subtype involved was pharmacologically characterized.
Hideaki Nouchi, Seri Kaeriyama, Akiko Muramatsu, Masumi Sato, Kunihiko Hirose, Nagako Shimizu, Hikaru Tanaka, Koki Shigenobu   +7 more
doaj  

The Interplay of Cross‐Organ Immune Regulation in Inflammation and Cancer

MedComm, Volume 6, Issue 7, July 2025.
Organs interact dynamically through immune regulation, influencing systemic immune responses and disease progression. We review molecular and cellular mechanisms of cross‐organ immune regulation in inflammation and cancer, focusing on gut, liver, and brain interactions with other organs.
Jie Dou, Jinzuo Jiang, Yangtao Xue, Xiaoqi Jiang, Yongzhuo Jiang, Peng Xiao, Junjie Xu   +6 more
wiley   +1 more source

Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders

British Journal of Pharmacology, Volume 182, Issue 14, Page 3044-3067, July 2025.
Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi, Caroline Gora, Ana Dudas, Xavier Leray, Véronique Bozon, Pascale Crépieux, Lucie P. Pellissier   +6 more
wiley   +1 more source

Targeting muscarinic receptors in schizophrenia treatment: Novel antipsychotic xanomeline/trospium chloride. [PDF]

World J Psychiatry
Pejčić AV.
europepmc   +1 more source