Results 241 to 250 of about 2,380,582 (287)

Phox2a in Lateral Spinal Nucleus Tac1‐Positive Neurons Mediates Histamine‐Independent Acute Itch

CNS Neuroscience &Therapeutics, Volume 31, Issue 11, November 2025.
Phox2a expression in LSNTac1 neurons is selectively reduced in chloroquine‐induced itch. Overexpression of Phox2a alleviates this itch by the amplitude of spontaneous excitatory postsynaptic currents, revealing a potential treatment target for histamine‐independent pruritus.
Yu‐Ling Chen, Zi‐Ang Li, Qing‐Zhen Wang, Xin‐Ran Wu, E. Mao, Yao‐Hua Liu, Zhi‐Ping Cai, Yun‐Qing Li, Zhen‐Zhen Kou   +8 more
wiley   +1 more source

From theory to therapy: unlocking the potential of muscarinic receptor activation in schizophrenia with the dual M1/M4 muscarinic receptor agonist xanomeline and trospium chloride and insights from clinical trials. [PDF]

Int J Neuropsychopharmacol
Meyer JM, Kramer K, Vuocolo S, Kaul I, Miller AC.   +4 more
europepmc   +1 more source

Ex Vivo Modulation of the BNST by Parabrachial CGRP Projections Is Decreased After a History of Stress‐Induced Anxiety

European Journal of Neuroscience, Volume 62, Issue 9, November 2025.
The current study in mice tested whether neuroadaptations in the parabrachial calcitonin gene‐related peptide to bed nucleus of the stria terminalis circuit are associated with a previous stress‐induced anxiogenic state. Repeated forced swim stress induced anxiety‐like behavior in novelty suppressed feeding test in naïve and in alcohol conditions. Next,
L. S. Kayat, N. Petersen, C. E. Van Doorn, B. P. Nabit, J. B. Tyree, S. W. Centanni, A. A. Jaramillo   +6 more
wiley   +1 more source

Bioorganic Chemistry, Toxinology, and Pharmaceutical Uses of <i>Datura</i> Metabolites and Derivatives. [PDF]

Toxins (Basel)
Thawabteh AM, Sulaiman S, Alabed IO, Scrano L, Karaman D, Karaman R, Bufo SA.   +6 more
europepmc   +1 more source

Real‐Time In Vivo Monitoring of Cholinergic Neurotransmission in the Mouse Brain Using a Microelectrochemical Choline Biosensor

European Journal of Neuroscience, Volume 62, Issue 9, November 2025.
The measurement of choline as a biomarker for in vivo cholinergic neurotransmission is a valuable tool in the study of a range of CNS disorders. However, the continuous detection of cholinergic neurotransmission in selective brain regions in the mouse brain remains challenging and underexploited.
Seán Doyle, Michelle M. Doran, Colm Cunningham, John Patrick Lowry   +3 more
wiley   +1 more source

Impaired neuromodulator crosstalk delays arousal-dependent astroglia Ca²⁺ activation in mouse models of Alzheimer's disease. [PDF]

iScience
Heo EY, Salinas-Birt A, Ye L, Sajadi S, Sarker MK, Yang Y, Paukert M.   +6 more
europepmc   +1 more source

Rapid Changes in Cholinergic Signaling, Myelination, and Thyroid Signaling Pathway Gene Expression in Amygdala Subnuclei in Response to Social Status Maintenance and Reorganization

European Journal of Neuroscience, Volume 62, Issue 9, November 2025.
ABSTRACT Male CD‐1 mice form linear social hierarchies and can rapidly reform them following social reorganization. Through tag‐based sequencing in the medial amygdala (MeA), we identified several genes regulating cholinergic signaling, myelination, and thyroid signaling that rapidly shift expression 70 min after animals change social status.
Tyler M. Milewski, Won Lee, Köll R. Rada, James P. Curley   +3 more
wiley   +1 more source

Different color lights on refractive status and secretion of neurotransmitters in the guinea pig model of myopia. [PDF]

Int J Ophthalmol
Li XX, Yu J, Zhang LY, Shen Y, Wu MQ.
europepmc   +1 more source

Synaptopathy in the TDP‐43ΔNLS Mouse Model of Sporadic Amyotrophic Lateral Sclerosis

European Journal of Neuroscience, Volume 62, Issue 10, November 2025.
ABSTRACT Sporadic cases of amyotrophic lateral sclerosis (sALS) represent the most common form of motor neuron disease. sALS is characterised by pathological cytoplasmic inclusions of TDP‐43, so‐called reactive astrocyte pathology and motor neuron degeneration.
Ani Ayvazian‐Hancock, Emma Butler, Claire F. Meehan, Gareth B. Miles, Matthew J. Broadhead   +4 more
wiley   +1 more source

The role of acetylcholine and its receptors in tumor immune regulation: mechanisms and potential therapeutic targets. [PDF]

Mol Cancer
Zhang C, Guo X, Wang Y, Zhang S, Wang Z.
europepmc   +1 more source