Results 241 to 250 of about 155,151 (336)

5‐Methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) for alcohol use disorder: An open‐label, phase 2, proof‐of‐concept, clinical trial

Addiction, EarlyView.
Abstract Background and Aims Psychedelic drugs may help treat alcohol use disorder (AUD). This study evaluated BPL‐003, a novel intranasal powder formulation of 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) benzoate salt, in people with moderate–severe AUD enrolled in a standard of care, 10‐week programme of relapse‐prevention oriented Cognitive ...
John Marsden, Michael Kelleher, Fiona Dunbar, Anna O. Ermakova, Luke Mitcheson, Claire Roberts, James J. Rucker, Gemma Scott, Ivan Saeger, Francesca Small, Mathieu Seynaeve   +10 more
wiley   +1 more source

New and emerging pharmacologic treatments for MDD. [PDF]

Front Psychiatry
Uyar A, Gonul AS.
europepmc   +1 more source

Pediatric N-methyl-d-aspartate receptor autoimmune encephalitis

Journal of Pediatric Neurosciences, 2018
openaire   +2 more sources

Intravenous methadone for pain management in cardiac surgery: a randomised controlled trial with plasma concentration analysis*

Anaesthesia, EarlyView.
Summary Introduction Postoperative pain after cardiac surgery remains significant despite the administration of opioids. Methadone may improve pain control and decrease the need for postoperative opioids. Randomised controlled trials, however, are limited and the effects of cardiopulmonary bypass on methadone pharmacokinetics are unclear.
Henry Man Kin Wong, Veronica Ka Wai Lai, Sandra Lok Ching Chiu, Wai Tat Wong, Siu Kwan Wo, Joan Zhong Zuo, Xiaodong Liu, Randolph Hung Leung Wong, Kwok Ming Ho   +8 more
wiley   +1 more source

GLR Channels Are Involved in the Mechanism of Chloroplast Avoidance Response in <i>Lemna trisulca</i>. [PDF]

Plants (Basel)
Krzeszowiec W, Gabryś H.
europepmc   +1 more source

Effect of peri‐operative pharmacological interventions on postoperative delirium in patients having cardiac surgery: a systematic review and Bayesian network meta‐analysis

Anaesthesia, EarlyView.
Summary Introduction Postoperative delirium is a common complication following cardiac surgery. Despite its known impact on patient outcomes, effective preventative strategies remain elusive. We aimed to perform a comprehensive Bayesian network meta‐analysis of randomised controlled trials assessing the effect of pharmacological interventions on the ...
Ivo Queiroz, Lucas M. Barbosa, Mariano Gallo Ruelas, Beatriz Araújo, Maria L. R. Defante, Arthur H. Tavares, Cynthia Florencio de Mesquita, Tulio Pimentel, Beatriz Ximenes Mendes, Iuri Ferreira Felix, André Rivera, Rafael Oliva Morgado Ferreira, Helen M. de Oliveira, Bruno B. Righetto, Nathan J. Smischney, Guangyu Tong, Daqing Ma   +16 more
wiley   +1 more source

Peri‐operative pain management in major lower extremity amputation in vascular Surgery: a UK anaesthetic and vascular surgery Delphi consensus study*

Anaesthesia, EarlyView.
Summary Introduction Major lower extremity amputations occurring secondary to vascular disease remain prevalent worldwide. Pain surrounding these procedures is complex, multifactorial and associated with poor functional and psychosocial outcomes. The evidence base informing pain management approaches in major lower extremity amputations remain largely ...
Thanapon Ekkunagul, Caitlin Sara MacLeod, Anna Celnik, John Chalmers, Ross Thomson, Alan J. R. Macfarlane, David Bosanquet, John Nagy, Patrice Forget, the Delphi expert panel, Abhijoy Chakladar, Ahmed Abidia, Alan Fayaz, Alan Macfarlane, Alasdair Taylor, Alastair Thomson, Alexander Bell, Amy Sadler, Andrea Harvey, Andrew Mitchell, Andrew Tambyraja, Andrew William Garnham, Andrey Varvinskiy, Ankur Thapar, Anna Celnik, Caroline Curry, Catherine Western, Catriona Semple, Christopher G Davies, Craig Forrest, David Bosanquet, Denis Harkin, Diane Rosemary Hildebrand, Douglas James MacKenzie, Emma Elizabeth Florence Scott, Emma Jannine Baird, Ferdinand Serracino‐Inglott, Fiona Myint, Frances Kent, Francesco Torella, Gareth Harrison, George A. Antoniou, George Edward Smith, Graeme A McLeod, Ian Chetter, Indran Raju, John Chalmers, John Nagy, John O'Donoghue, Jonathan Paul Seeley, Kaji Sritharan, Keith Hussey, Keith Jones, Kersten Morgan Bates, Kevin Graham Mercer, Kieran Murphy, Lisa Anne Grimes, Matt Metcalfe, Maureen Sweeney, Michael McCusker, Michael Neil, Michelle Lamont, Mohamed Elsherif, Nat Haslam, Naveeta Maini, Nicholas Stuart Greaves, Patrick Coughlin, Patrice Forget, Peter Merjavy, Robert Hinchliffe, Rob Sayers, Ross Thomson, Russell William Jamieson, Sachin R Kulkarni, Sandeep Bahia, Sandip Nandhra, Serena Goon, Tanim Siddiqui, Tim Stansfield, Vanessa Fludder, Vikas Kaura, Vishal Gupta   +81 more
wiley   +1 more source

A novel de novo AP2M1 variant in a patient with attention-deficit/hyperactivity disorder, oppositional defiant disorder, and unexpected hemiplegic migraine. [PDF]

Headache
Mangano GD, Antona V, Santangelo G, Di Pasquale G, Colella J, Salpietro V, Mangano GR, Raieli V.   +7 more
europepmc   +1 more source

Reflections on Consciousness in Intensive Care

Acta Paediatrica, EarlyView.
ABSTRACT Evaluating consciousness in intensive care is pivotal to relieving suffering with analgesic or sedative drugs and in prognosis and diagnoses. The usual clinical perspective is to equate consciousness with responsiveness, assuming functional motor responses and sympathetic activity of the patient. Clinical diagnoses of coma may be wrong in more
Michael Broomé, Tiit Mathiesen
wiley   +1 more source

The neuroendocrine regulation of hepatic cytochrome P450 by N-methyl-D-aspartate receptors in the paraventricular and arcuate nuclei of the hypothalamus. [PDF]

Drug Metab Dispos
Pukło R, Bromek E, Basińska-Ziobroń A, Haduch A, Kuban W, Danek PJ, Daniel WA.   +6 more
europepmc   +1 more source