Results 251 to 260 of about 156,800 (338)

Centrally administered thromboxane A₂ analogue facilitates the micturition reflex in rats. [PDF]

Sci Rep
Hamada C, Shimizu T, Togo M, Higashi Y, Shimizu N, Furumiya J, Saito M.   +6 more
europepmc   +1 more source

Gene therapy for epilepsy: An emerging, promising approach for a serious neurological disorder

Journal of Internal Medicine, EarlyView.
Abstract Gene therapy is emerging as a groundbreaking strategy for treating epilepsy, offering new hope to patients who do not respond to conventional medications. Despite advancements in anti‐seizure treatments, nearly 30%–40% of individuals with epilepsy continue to experience uncontrolled seizures, highlighting the urgent need for more effective and
Marco Ledri, Merab Kokaia
wiley   +1 more source

A mouse model of GRIN2D developmental and epileptic encephalopathy recapitulates the human disease. [PDF]

Brain
Yam M, Nassir J, Galber D, Quinn S, Gal R, Ovadia M, Bordeynik-Cohen M, Peled E, Makinson CD, Hausman-Kedem M, Fattal-Valevski A, Frankel WN, Avraham KB, Rubinstein M.   +13 more
europepmc   +1 more source

Pharmacokinetics and Safety of a Single Subcutaneous or Intramuscular Dose of Ketamine in Healthy Horses

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Pharmacokinetics (PK) of intramuscular (IM) and subcutaneous (SC) ketamine in horses has not been described. This study aimed to evaluate the PK and safety of ketamine and its metabolites after a single SC or IM administration. In Phase 1, two horses received 0.5 or 1 mg/kg of ketamine via SC and IM routes.
Ana Rangel, Debra C. Sellon, Macarena G. Sanz, Erin Pinnell, Zuzanna M. Pietras, Nicolas F. Villarino   +5 more
wiley   +1 more source

Disrupted astrocyte-neuron glutamine-glutamate cycling in the medial prefrontal cortex contributes to depression-like behaviors. [PDF]

Int J Biol Sci
Kang JS, Baek JH, Park H, Rehman NU, Chung HJ, Lee DK, Oh S, Kim HJ.   +7 more
europepmc   +1 more source

A Systematic Review of the Effects of N-Methyl-D-Aspartate Receptor Antagonists on Pancreatic Islets.

Neuroendocrinology
Wong S, Le GH, Uhlig J, Yang E, Dri CE, Rosenblat JD, Mansur RB, McIntyre RS.   +7 more
europepmc   +1 more source

The Role of Peripheral N-Methyl-D-Asparate (NMDA) Receptors in Itch and Pain: A Narrative Review. [PDF]

Eur J Pain
Tanaka R, Lo Vecchio S, Aliotta GE, Arendt-Nielsen L.   +3 more
europepmc   +1 more source

Immune involvement in neuropsychiatric disorders: Insights from single‐cell transcriptomic studies

Psychiatry and Clinical Neurosciences, EarlyView.
Neuropsychiatric disorders pose profound challenges to both research and treatment, largely due to their clinical heterogeneity and the limited understanding of their underlying biological mechanisms. While bulk RNA sequencing (bulk RNA‐seq) has been widely used to study gene expression, it cannot resolve cell‐type‐specific signals or detect rare ...
Tsutomu Takeda, Michihiro Toritsuka, Hiroto Tamakoshi, Nakao Iwata, Manabu Makinodan   +4 more
wiley   +1 more source

Anti-NMDAR antibodies are not prevalent in Lyme neuroborreliosis: a retrospective cohort study. [PDF]

BMC Neurol
Florescu AM, Bryrup T, Nilsson AC, Blaabjerg M, Lebech AM, Mens H.   +5 more
europepmc   +1 more source