Results 71 to 80 of about 178,836 (311)

Comparative analyses of rodent and human brain in ageing and disease using novel NMDAR-2B selective probes [PDF]

, 2007
The NMDA subtype of excitatory ionotropic glutamate receptors is a hetero-oligomeric ligand-gated ion channel. Molecular cloning techniques have identified three types of NMDA receptor subunits, the NR 1, NR2A-D, and NR3A-B. NR2B-containing receptors are
Sheahan, Rebecca Louise
core  

Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

Neural Regeneration Research
The involvement of the excitatory amino acids glutamate and aspartate in cerebral ischemia and excitotoxicity is well-documented. Nevertheless, the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely ...
Victoria Jiménez Carretero, Iris Álvarez-Merz, Jorge Hernández-Campano, Sergei A. Kirov, Jesús M. Hernández-Guijo   +4 more
doaj   +1 more source

Selective vulnerabilities of N-methyl-D-aspartate (NMDA) receptors during brain aging

Frontiers in Aging Neuroscience, 2010
N-methyl-D-aspartate (NMDA) receptors are present in high density within the cerebral cortex and hippocampus and play an important role in learning and memory.
Brenna L Brim, Siba R Das
doaj   +1 more source

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

Estudo dos mecanismos envolvidos no efeito neuroprotetor do pré-condicionamento com N-Metil-D-Aspartato (NMDA) [PDF]

, 2014
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Neurociências, Florianópolis, 2014.O pré-condicionamento cerebral é caracterizado por um estado de tolerância transitória do tecido ...
Constantino, Leandra Celso
core  

A study in rat brain cortex synaptic vesicles of endogenous ligands for n-methyl-d-aspartate receptors [PDF]

, 1990
The presence of endogenous ligands for the N-methyl-d-aspartate receptor was looked for in highly purified rat brain cortex synaptic vesicles, the contents of which were extracted and fractionated by gel filtration on Sephadex G-10, or by three different
Fiedler Temer, Jenny, Villanueva, S., Orrego, F.   +2 more
core   +1 more source

An Anterior Cingulate Cortex‐Anterior Insular Cortex Glutamatergic Circuit Gates Stress‐Induced Visceral Hypersensitivity and Anxiety via Ionotropic Glutamate Receptors Trafficking

Advanced Science, EarlyView.
This study identifies an anterior cingulate cortex (ACC) to anterior insular cortex (AIC) glutamatergic (Glu) circuit that gates stress induced visceral hypersensitivity and anxiety. Circuit activation induces both phenotypes, whereas inhibition relieves them.
Junwen Wang, Guangbing Duan, Huihui Sun, Zhiyu Dong, Qiwei Wang, Xiaowei Li, Ying Chen, Shuchang Xu, Ying Huang   +8 more
wiley   +1 more source

Identifying potential GluN2B subunit containing N-Methyl-D-aspartate receptor inhibitors: an integrative in silico and molecular modeling approach [PDF]

, 2019
N-methyl-D-aspartate receptors (NMDARs), a class of ligand-gated ion channels, are involved in non-selective cation transport across the membrane. These are contained in glutamatergic synapse and produce excitatory effects leading to synaptic plasticity ...
Dileep Kumar (6576593), Sushil Kumar Singh (322135), Ashok Kumar (43100), Ankit Ganeshpurkar (6914552), Ravi Singh (2437474), Devendra Kumar (451212)   +5 more
core   +1 more source

The Role of N-Methyl D-Aspartate Receptors on Pain Transmission

Çukurova Üniversitesi Tıp Fakültesi Dergisi, 2012
Aim : In the experimental studies, NMDA (N-methyl-D-aspartate) receptors play important role in the mechanism of action among the drugs used for the treatment of pain.
Yasemin Gunes, Tufan Mert, Dilek Ozcengiz, Ismail Gunay   +3 more
doaj  

Localization and interaction of N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors of lamprey spinal neurons

Biophysical Journal, 1995
Small volumes of N-Methyl-D-Aspartate (NMDA) and non-NMDA excitatory amino acid receptor agonists were applied to localized regions of the dendritic trees of lamprey spinal neurons along their medial-lateral axis to obtain a spatial map of glutamate receptor distribution.
Moore, L. E., Buchanan, James T., Murphey, C. R.   +2 more
openaire   +2 more sources