Results 81 to 90 of about 148,087 (354)
Advanced Science, EarlyView.GLS1 is a novel contributor to arterial calcification. GLS1‐catalyzed glutamate exerts the promoting effects on osteogenic reprogramming in arteries. NMDAR, a glutamate receptor, is also activated and overexpressed during arterial calcification.
Ziting Zhou +18 more
wiley +1 more source
The Role of N-Methyl D-Aspartate Receptors on Pain Transmission
Cukurova Medical Journal, 2012 Aim : In the experimental studies, NMDA (N-methyl-D-aspartate) receptors play important role in the mechanism of action among the drugs used for the treatment of pain.
Yasemin Gunes +3 more
doaj +2 more sources
Antibacterial Siderophores of Pandoraea Pathogens and Their Impact on the Diseased Lung Microbiota
Angewandte Chemie, EarlyView.Genome mining of environmental and pathogenic Pandoraea species identified a conserved NRPS gene cluster and led to the discovery of novel siderophores, pandorabactins, which exert their antibacterial activity by depleting iron from competitors. Bioinformatic analysis of sputum from cystic fibrosis patients coupled with bioassays indicates that ...
Elena Herzog +8 more
wiley +2 more sources
D-Amino Acids in the Nervous and Endocrine Systems
Scientifica, 2016 Amino acids are important components for peptides and proteins and act as signal transmitters. Only L-amino acids have been considered necessary in mammals, including humans. However, diverse D-amino acids, such as D-serine, D-aspartate, D-alanine, and D-
Yoshimitsu Kiriyama, Hiromi Nochi
doaj +1 more source
Molecular Imaging Probes for N-Methyl-D-Aspartate Receptors [PDF]
, 2014 The non-invasive detection of neuronal transmission is of prime importance in order to understand brain function better. This will aid cognitive neuroscience, as well as medical science, in the early detection of diseased states.
SIM, NEIL
core
[Ca2+]i regulation by glutamate receptor agonists in cultured chick retina cells [PDF]
, 1996 The effect of glutamate receptor agonists on the intracellular free calcium concentration ([Ca2+]i), measured with Indo-1, was studied in populations of cultured chick embryonic retina cells.
Carvalho, Arsélio P. +2 more
core +1 more source
Advanced Science, EarlyView.IR783‐stabilized nanodrugs composed of NIR dye IR783, ROS inducer β‐lapachone, and epigenetic modulator CUDC101 are designed for breast cancer immunotherapy. The nanodrugs can not only promote cancer cell apoptosis through HDAC inhibition‐enhanced oxidation therapy but also reshape the immunosuppressive microenvironment, which provides a novel strategy
Jinzhao Liu +6 more
wiley +1 more source
Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer’s disease
Neural Regeneration ResearchStroke and Alzheimer’s disease are common neurological disorders and often occur in the same individuals. The comorbidity of the two neurological disorders represents a grave health threat to older populations.
Shan Ping Yu +3 more
doaj +1 more source
Subunit Arrangement in N-Methyl-d-aspartate (NMDA) Receptors [PDF]
Journal of Biological Chemistry, 2010 N-Methyl-d-aspartate (NMDA) receptors, the main mediators of excitatory synaptic transmission, are heterotetrameric receptors. Typically, glycine binding NR1 subunits co-assemble with glutamate binding NR2 subunits to form a functional receptor. Here we have used luminescence resonance energy transfer (LRET) investigations to establish the specific ...
Anu Rambhadran +2 more
openaire +3 more sources
Advanced Science, EarlyView.S‐ketamine binds directly to SIRT2, facilitating its interaction with NF‐κB p65. This interaction reduces the acetylation of NF‐κB p65 and inhibits its activation, thereby exerting anti‐inflammatory and antidepressant effects. Created by BioRender.
Cong Lin +7 more
wiley +1 more source