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Evolutionary history of the neuropeptide S receptor/neuropeptide S system
General and Comparative Endocrinology, 2014The neuropeptide S receptor (NPSR) belongs to the G protein-coupled receptor (GPCR) superfamily and is activated by the neuropeptide S (NPS). Although recently discovered, the vertebrate NPSR-NPS system has been established as an important signaling system in the central nervous system and is involved in physiological processes such as locomotor ...
Ravisankar, Valsalan, Narayanan, Manoj
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Emerging functions for neuropeptide Y5 receptors
Trends in Pharmacological Sciences, 1999The Y5 subtype of neuropeptide Y (NPY) receptors has raised considerable interest as a mediator of NPY-stimulated food intake, but with the advent of recent data, this hypothesis has come into question. Moreover, Y5 receptor-selective drugs might not be specific for food intake because additional functions in the central and peripheral nervous systems,
Bischoff, A., Michel, M. C.
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Neuropeptide Y receptor antagonists in obesity
Expert Opinion on Investigational Drugs, 1997Neuropeptide Y (NPY) is a 36 amino acid amidated peptide with high sequence homology to the endocrine peptides, peptide YY (PYY) and pancreatic polypeptide (PP). They appear to interact with a family of receptors that possess high affinity for one or more of these peptides.
D R, Gehlert, P A, Hipskind
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Intracellular Trafficking of Neuropeptide Y Receptors
2015The multireceptor multiligand system of neuropeptide Y receptors and their ligands is involved in the regulation of a multitude of physiological and pathophysiological processes. Specific expression patterns, ligand-binding modes, and signaling properties contribute to the complex network regulating distinct cellular responses.
Karin, Mörl, Annette G, Beck-Sickinger
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Immunocytochemistry of Neuropeptides and Their Receptors
1977Peripheral cells talk to each other via hormones. The message, although diffused into the bloodstream, is picked up selectively by those groups of cells that possess specific receptors for it. Neurons also talk to each other via hormones. By virtue of the axonal networks, they are able to direct a message to receptors on specific synapses with ...
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Neuropeptide families and their receptors: evolutionary perspectives
Brain Research, 1999Examination of families of neuropeptides and their receptors can provide information about phyletic relationships and evolutionary processes. Within an individual a given signal molecule may serve many diverse functions, mediated via subtypes of the receptor which may be coupled to their transduction mechanisms in different ways.
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