Results 251 to 260 of about 100,886 (308)
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Inhibitory neuropeptide receptors on macrophages
Microbes and Infection, 2001The immune response, both in innate and adaptive immunity, is controlled at several levels, including signaling from the central nervous system. Neuropeptides released within the lymphoid organs modulate the immune response, either as stimulators or inhibitors.
D, Ganea, M, Delgado
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The structure of neuropeptide receptors
European Journal of Pharmacology: Molecular Pharmacology, 1992Recently, the primary structures of 17 different receptors for neuropeptides and small peptide hormones have been elucidated by molecular cloning. All but one belong to the superfamily of G-protein coupled receptors which share a topography consisting of seven transmembrane domains.
J P, Burbach, O C, Meijer
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Sorting of neuropeptides and neuropeptide receptors into secretory pathways
Progress in Neurobiology, 2010There are two major secretory pathways in neurons, the regulated pathway and the constitutive pathway. Neuropeptides and other regulated secretory proteins are known to be sorted into large dense-core vesicles of the regulated pathway in the trans-Golgi network and are secreted upon stimulus-induced increases in intracellular Ca(2+).
Xu, Zhang, Lan, Bao, Guo-Qiang, Ma
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2002
Abstract Neuropeptide Y (NPY) was isolated from porcine brain almost two decades ago (Tatemoto and Mutt 1980). This 36 amino acid residues shares high sequence homology and structural identity with two other peptides, namely peptide YY (PYY) and pancreatic polypeptide (PP) (Tatemoto et al . 1982).
Yvan Dumont +2 more
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Abstract Neuropeptide Y (NPY) was isolated from porcine brain almost two decades ago (Tatemoto and Mutt 1980). This 36 amino acid residues shares high sequence homology and structural identity with two other peptides, namely peptide YY (PYY) and pancreatic polypeptide (PP) (Tatemoto et al . 1982).
Yvan Dumont +2 more
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Neuropeptide-Mediated Receptor Trafficking
Science's STKE, 2005Guan et al. have provided an intriguing link between pain pathways and pathways that mediate analgesia by demonstrating that protachykinin--the precursor to the pain-promoting neuropeptide substance P--regulates insertion of the δ-opioid receptor (DOR) into the plasma membrane.
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Neuropeptide Y1 subtype pharmacology of a recombinantly expressed neuropeptide receptor.
Molecular Pharmacology, 1992Neuropeptide Y (NPY) is an important central and peripheral modulator of neural and endocrine functions. This neuropeptide interacts with at least two pharmacologically distinct receptors, termed Y1 and Y2. At Y1 receptors, the NPY analog [Leu31,Pro34] NPY, but not the carboxyl-terminal fragment NPY-(18-36), displaces radiolabeled NPY and the sequence ...
Krause, J. +3 more
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Evolutionary history of the neuropeptide S receptor/neuropeptide S system
General and Comparative Endocrinology, 2014The neuropeptide S receptor (NPSR) belongs to the G protein-coupled receptor (GPCR) superfamily and is activated by the neuropeptide S (NPS). Although recently discovered, the vertebrate NPSR-NPS system has been established as an important signaling system in the central nervous system and is involved in physiological processes such as locomotor ...
Ravisankar, Valsalan, Narayanan, Manoj
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Identification of a platyhelminth neuropeptide receptor
International Journal for Parasitology, 2007We report the characterisation of the first neuropeptide receptor from the phylum Platyhelminthes, an early-diverging phylum which includes a number of important human and veterinary parasites. The G protein-coupled receptor (GPCR) was identified from the model flatworm Girardia tigrina (Tricladida: Dugesiidae) based on the presence of motifs widely ...
Hanan H, Omar +7 more
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Neuropeptide Y receptor antagonists in obesity
Expert Opinion on Investigational Drugs, 1997Neuropeptide Y (NPY) is a 36 amino acid amidated peptide with high sequence homology to the endocrine peptides, peptide YY (PYY) and pancreatic polypeptide (PP). They appear to interact with a family of receptors that possess high affinity for one or more of these peptides.
D R, Gehlert, P A, Hipskind
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Emerging functions for neuropeptide Y5 receptors
Trends in Pharmacological Sciences, 1999The Y5 subtype of neuropeptide Y (NPY) receptors has raised considerable interest as a mediator of NPY-stimulated food intake, but with the advent of recent data, this hypothesis has come into question. Moreover, Y5 receptor-selective drugs might not be specific for food intake because additional functions in the central and peripheral nervous systems,
Bischoff, A., Michel, M. C.
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