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Human kisspeptins activate neuropeptide FF2 receptor
Neuroscience, 2010We studied the possible activation of a neuropeptide FF2 receptor (NPFF2R) by kisspeptins, neuropeptides derived from the mouse and human metastin or Kiss-1 precursor. The hypothesis was that the human kisspeptins, which share the C-terminal dipeptide RF-NH(2) with NPFF, might activate the NPFF2R, as has previously been shown for two related peptides ...
Y, Lyubimov +5 more
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Strategies in neuropeptide receptor binding research
Neuroscience & Biobehavioral Reviews, 1985Strategies and general approaches used in neuropeptide receptor binding assays are described. Special attention is given to the nature of the ligand, its physical and chemical stability and the demonstration of an appropriate ligand selectivity pattern. Examples are given to illustrate critical aspects of neuropeptide receptor binding assays.
R, Quirion, P, Gaudreau
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Neuropeptide Y receptor antagonists
Expert Opinion on Therapeutic Patents, 1999On the basis of pharmacological observations, neuropeptide Y (NPY) has been implicated to be involved in numerous physiological functions. Preliminary results suggest a wide therapeutic utility for NPY antagonists in disorders such as anxiety, appetite stimulation, obesity, alcohol intake, hypertension, and regulation of coronary tone. This review will
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Dihydropyridine Neuropeptide Y Y1 Receptor Antagonists
Bioorganic & Medicinal Chemistry Letters, 2002Dihydropyridine 5a was found to be an inhibitor of neuropeptide Y(1) binding in a high throughput (125)I-PYY screening assay. Structure-activity studies around certain portions of the dihydropyridine chemotype identified BMS-193885 (6e) as a potent and selective Y(1) receptor antagonist.
Graham S, Poindexter +13 more
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Intracellular Trafficking of Neuropeptide Y Receptors
2015The multireceptor multiligand system of neuropeptide Y receptors and their ligands is involved in the regulation of a multitude of physiological and pathophysiological processes. Specific expression patterns, ligand-binding modes, and signaling properties contribute to the complex network regulating distinct cellular responses.
Karin, Mörl, Annette G, Beck-Sickinger
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Kinetic Profile of Neuropeptide–Receptor Interactions
Trends in Neurosciences, 2016Currently, drug discovery focusses only on quantifying pharmacological parameters, sometimes including binding kinetics, of drug candidates. For a complete understanding of a drug's desired binding kinetics, the kinetics of both the target and its endogenous ligands should be considered.
Nederpelt +4 more
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[Hypothalamic hypophysiotropic neuropeptide receptors].
Annales d'endocrinologie, 1990The present review is dealing with the five major hypothalamic hypophysiotropic neuropeptides (H.H.N.P.) purified and synthesized so far. Four of them specifically stimulate the secretion of one or several anterior pituitary (A.P.) hormones, i.e. thyroliberin (TRH) on TSH and prolactin, gonadoliberin (GnRH) on LH and FSH, corticoliberin (CRF) on ACTH ...
A, Tixier-Vidal, D, Gourdji
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Neuropeptide Y receptor antagonists.
IDrugs : the investigational drugs journal, 2005A review of the patent literature for neuropeptide Y (NPY) antagonists is presented for the period of January 2000 to March 2001. This review focuses on antagonists of the Y(1) and Y(5) receptor subtypes, which have been of primary interest as anti-obesity agents.
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
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