Results 1 to 10 of about 27,803 (242)

Neuropeptides as regulators of bone metabolism: from molecular mechanisms to traditional Chinese medicine intervention strategies [PDF]

Frontiers in Pharmacology
Osteoporosis (OP) is a complex bone metabolism disorder disease that affects the skeleton, nervous system, muscles, and multiple tissues. Neuropeptides, which are endogenous substances derived from both bone and brain, play a critical role in maintaining
Qing Lin, Qing Lin, Biyi Zhao, Jiajia Huang, Rumeng Chen, Weipeng Sun, Qianyun Ye, Qianyun Ye, Li Yang, Li Yang, Xiaofeng Zhu, Xiaofeng Zhu, Xiaofeng Zhu, Xiaoyun Li, Xiaoyun Li, Ronghua Zhang, Ronghua Zhang   +16 more
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Neuropeptide Y modulates the electrical activity of subfornical organ neurons [PDF]

Current Research in Neurobiology
The subfornical organ (SFO) is a sensory circumventricular organ, lacking a blood-brain barrier. It is well-recognized as a key center for detection and integration of osmotic, ionic and hormonal signals for maintenance of hydromineral balance and ...
Lauren Shute, Mark Fry
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Unusually persistent Gαi-signaling of the neuropeptide Y2 receptor depletes cellular Gi/o pools and leads to a Gi-refractory state

Cell Communication and Signaling, 2020
Background A sensitive balance between receptor activation and desensitization is crucial for cellular homeostasis. Like many other GPCR, the human neuropeptide Y2 receptor (hY2R) undergoes ligand dependent activation and internalization into ...
Isabelle Ziffert, Anette Kaiser, Stefanie Babilon, Karin Mörl, Annette G. Beck-Sickinger   +4 more
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PET Imaging of the Neuropeptide Y System: A Systematic Review

Molecules, 2022
Neuropeptide Y (NPY) is a vastly studied biological peptide with numerous physiological functions that activate the NPY receptor family (Y1, Y2, Y4 and Y5).
Inês C. F. Fonseca, Miguel Castelo-Branco, Cláudia Cavadas, Antero J. Abrunhosa   +3 more
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Echinoderms provide missing link in the evolution of PrRP/sNPF-type neuropeptide signalling

eLife, 2020
Neuropeptide signalling systems comprising peptide ligands and cognate receptors are evolutionarily ancient regulators of physiology and behaviour.
Luis Alfonso Yañez-Guerra, Xingxing Zhong, Ismail Moghul, Thomas Butts, Cleidiane G Zampronio, Alexandra M Jones, Olivier Mirabeau, Maurice R Elphick   +7 more
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Structural basis for ligand recognition of the neuropeptide Y Y2 receptor

Nature Communications, 2021
The human neuropeptide Y receptor Y2 (Y2R) is a drug target for the treatment of obesity and anxiety. Crystal structure of Y2R bound to a selective antagonist and accompanying mutagenesis provide insights into ligand recognition and subtype specificity ...
Tingting Tang, Christin Hartig, Qiuru Chen, Wenli Zhao, Anette Kaiser, Xuefeng Zhang, Hui Zhang, Honge Qu, Cuiying Yi, Limin Ma, Shuo Han, Qiang Zhao, Annette G. Beck-Sickinger, Beili Wu   +13 more
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Neuropeptide System Regulation of Prefrontal Cortex Circuitry: Implications for Neuropsychiatric Disorders

Frontiers in Neural Circuits, 2022
Neuropeptides, a diverse class of signaling molecules in the nervous system, modulate various biological effects including membrane excitability, synaptic transmission and synaptogenesis, gene expression, and glial cell architecture and function. To date,
Sanne M. Casello, Rodolfo J. Flores, Hector E. Yarur, Huikun Wang, Monique Awanyai, Miguel A. Arenivar, Rosario B. Jaime-Lara, Rosario B. Jaime-Lara, Hector Bravo-Rivera, Hugo A. Tejeda   +9 more
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Identification of neuropeptides and neuropeptide receptor genes in Phauda flammans (Walker)

Scientific Reports, 2022
Neuropeptides and neuropeptide receptors are crucial regulators to insect physiological processes. The 21.0 Gb bases were obtained from Illumina sequencing of two libraries representing the female and male heads of Phauda flammans (Walker) (Lepidoptera ...
Hai-Pan Wu, Xiao-Yun Wang, Jin Hu, Ran-Ran Su, Wen Lu, Xia-Lin Zheng   +5 more
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A Promising Therapeutic Target for Metabolic Diseases: Neuropeptide Y Receptors in Humans

Cellular Physiology and Biochemistry, 2017
Human neuropeptide Y (hNPY) is one of the most widely expressed neurotransmitters in the human central and peripheral nervous systems. It consists of 36 highly conserved amino acid residues, and was first isolated from the porcine hypothalamus in 1982 ...
Min Yi, Hekai Li, Zhiye Wu, Jianyun Yan, Qicai Liu, Caiwen Ou, Minsheng Chen   +6 more
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Structural basis of neuropeptide Y signaling through Y1 receptor

Nature Communications, 2022
The human neuropeptide Y (NPY) acts through G-protein coupled receptors and is involved in food intake, stress response, anxiety, and memory retention.
Chaehee Park, Jinuk Kim, Seung-Bum Ko, Yeol Kyo Choi, Hyeongseop Jeong, Hyeonuk Woo, Hyunook Kang, Injin Bang, Sang Ah Kim, Tae-Young Yoon, Chaok Seok, Wonpil Im, Hee-Jung Choi   +12 more
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