Neuropeptide Y receptors: How to get subtype selectivity [PDF]
Frontiers in Endocrinology, 2013 The neuropeptide Y system is a multireceptor/multiligand system consisting of four receptors in humans (hY1, hY2, hY4, hY5) and three agonists (NPY, PYY, PP) that activate these receptors with different potency.
Xavier ePedragosa Badia +2 more
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Structural basis for ligand recognition of the neuropeptide Y Y2 receptor
Nature Communications, 2021 The human neuropeptide Y receptor Y2 (Y2R) is a drug target for the treatment of obesity and anxiety. Crystal structure of Y2R bound to a selective antagonist and accompanying mutagenesis provide insights into ligand recognition and subtype specificity ...
Tingting Tang +13 more
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Structural basis of neuropeptide Y signaling through Y1 receptor
Nature Communications, 2022 The human neuropeptide Y (NPY) acts through G-protein coupled receptors and is involved in food intake, stress response, anxiety, and memory retention.
Chaehee Park +12 more
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A Promising Therapeutic Target for Metabolic Diseases: Neuropeptide Y Receptors in Humans
Cellular Physiology and Biochemistry, 2017 Human neuropeptide Y (hNPY) is one of the most widely expressed neurotransmitters in the human central and peripheral nervous systems. It consists of 36 highly conserved amino acid residues, and was first isolated from the porcine hypothalamus in 1982 ...
Min Yi +6 more
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Functional and genetic characterization of neuropeptide Y-like receptors in Aedes aegypti. [PDF]
PLoS Neglected Tropical Diseases, 2013 BACKGROUND:Female Aedes aegypti mosquitoes are the principal vector for dengue fever, causing 50-100 million infections per year, transmitted between human and mosquito by blood feeding. Ae.
Jeff Liesch +2 more
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Empowering exhausted T cells of Glioblastoma patients by Neurotransmitters and Neuropeptides: decreasing immune checkpoint inhibitors, and increasing CD3zeta, proliferation and Glioblastoma arrest [PDF]
Cancer Immunology, ImmunotherapyBackground Glioblastoma is the most common malignant brain tumor, with extremely poor prognosis, and patient’s T cells are exhausted, dysfunctional, and unable to eliminate Glioblastoma.
Mia Levite +3 more
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The Role of Neuropeptide Y in Cardiovascular Health and Disease
Frontiers in Physiology, 2018 Neuropeptide Y (NPY) is an abundant sympathetic co-transmitter, widely found in the central and peripheral nervous systems and with diverse roles in multiple physiological processes.
Cheryl M. J. Tan +5 more
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Cell Reports, 2013 Human monogenic obesity syndromes, including Bardet-Biedl syndrome (BBS), implicate neuronal primary cilia in regulation of energy homeostasis. Cilia in hypothalamic neurons have been hypothesized to sense and regulate systemic energy status, but the ...
Alexander V. Loktev, Peter K. Jackson
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The Role of Neuropeptide Y in the Nucleus Accumbens
International Journal of Molecular Sciences, 2021 Neuropeptide Y (NPY), an abundant peptide in the central nervous system, is expressed in neurons of various regions throughout the brain. The physiological and behavioral effects of NPY are mainly mediated through Y1, Y2, and Y5 receptor subtypes, which ...
Masaki Tanaka +2 more
semanticscholar +1 more source
Differential Changes in Expression of Stress- and Metabolic-related Neuropeptides in the Rat Hypothalamus during Morphine Dependence and Withdrawal [PDF]
, 2013 Chronic morphine treatment and naloxone precipitated morphine withdrawal activates stress-related brain circuit and results in significant changes in food intake, body weight gain and energy metabolism.
Ferenczi, Szilamér +6 more
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