Results 201 to 210 of about 40,251 (303)

Reduced cardiovascular mortality at moderate altitude: a putative role of physical activity and body mass

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Benefits of performing physical exercise at moderate altitude. At moderate altitude, increased resting metabolic rate and physical exertion promote physical fitness and exercise tolerance, whereas hypoxia suppresses appetite and elicits adaptations that increase tissue O2 delivery while augmenting O2‐independent ATP production ...
Robert T. Mallet   +6 more
wiley   +1 more source

Hypoxia‐induced vulnerability of the somatosensory nervous system

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Sensory neurons are highly energy dependent and rely on sufficient oxygen availability to maintain metabolic stability and effective neurocommunication. Within the somatosensory system, even modest reductions in tissue oxygen tension impair neuronal respiration, forcing a shift toward less efficient metabolic pathways that ...
Jack Corbett, Richard P. Hulse
wiley   +1 more source

Intrinsic pH chemosensitivity of acutely dissociated medullary serotonergic and retrotrapezoid neurones

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Central respiratory chemoreceptors (CRCs) are critical for maintaining normal systemic levels of pH and PCO2. A CRC must respond to pH via intrinsic mechanisms. Here we quantified intrinsic chemosensitivity of medullary 5‐HT neurones and retrotrapezoid nucleus (RTN) neurones using acute dissociation.
Yuanming Wu   +2 more
wiley   +1 more source

Genetic Variability in OXTR Polymorphism and Infant Reactivity to Ostracism Experiences

open access: yesDevelopmental Psychobiology, Volume 68, Issue 4, July 2026.
ABSTRACT The oxytocin system is central to regulating social behaviors, with genetic variations in the oxytocin receptor gene (OXTR), particularly the rs53576 single nucleotide polymorphism (SNP), linked to individual differences in emotional reactivity and social cognition. GG genotype carriers typically show heightened sensitivity to social dynamics,
Testa Alessia   +6 more
wiley   +1 more source

Evolution of neurohormone function revealed by actions of kisspeptin-type peptides in an echinoderm. [PDF]

open access: yesBMC Biol
Islam T   +5 more
europepmc   +1 more source

Relationship Between Central Sensitization and Genetic Polymorphisms—A Case–Control Study in Fibromyalgia

open access: yesEuropean Journal of Pain, Volume 30, Issue 6, July 2026.
ABSTRACT Background Fibromyalgia is a syndrome characterised by widespread chronic pain, which is believed to be mediated by a state of central sensitisation (CS). Based on the hypothesis that CS itself could have genetic determinants, our aim was to further explore this pathway.
Nicolas Macian   +8 more
wiley   +1 more source

Mechanistic insights into cartilage-sensory nerve crosstalk in osteoarthritis progression. [PDF]

open access: yesJ Orthop Translat
Meng H   +7 more
europepmc   +1 more source

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