Results 291 to 300 of about 197,147 (332)

Neuropeptide Y Receptor Subtypes, Y1 and Y2

Annals of the New York Academy of Sciences, 1990
Heterogeneity among NPY (and PYY) receptors was first proposed on the basis of studies on sympathetic neuroeffector junctions, where NPY (and PYY) can exert three types of action: 1) a direct (e.g., vasoconstrictor) response; 2) a postjunctional potentiating effect on NE-evoked vasoconstriction; and 3) a prejunctional suppression of stimulated NE ...
C, Wahlestedt, L, Grundemar, R, Håkanson, M, Heilig, G H, Shen, Z, Zukowska-Grojec, D J, Reis   +6 more
openaire   +2 more sources

Novel non-peptidic neuropeptide Y Y 2 receptor antagonists

Bioorganic & Medicinal Chemistry Letters, 2004
Through SAR studies of a piperidinylindoline cinnamide HTS lead, the first potent, non-peptide, low molecular weight selective Neuropeptide Y Y2 (NPY Y2) antagonists have been synthesized. The SAR studies around the piperidinyl, the indolinyl, and the cinnamyl moieties are discussed.
Jill A, Jablonowski, Wenying, Chai, Xiaobing, Li, Dale A, Rudolph, William V, Murray, Mark A, Youngman, Scott L, Dax, Diane, Nepomuceno, Pascal, Bonaventure, Timothy W, Lovenberg, Nicholas I, Carruthers   +10 more
openaire   +2 more sources

Effect of a selective neuropeptide Y Y2 receptor antagonist, BIIE0246 on neuropeptide Y release

European Journal of Pharmacology, 2000
We have examined the selective neuropeptide Y Y(2) receptor antagonist, (S)-N(2)-[[1-[2-[4-[(R,S)-5,11-dihydro-6(6h)-oxodibenz[b, e]azepin-11-yl]-1-piperazinyl]-2-oxoethyl]cyclopentyl]acetyl ]-N-[2-[1 ,2-dihydro-3,5(4H)-dioxo-1,2-diphenyl-3-H-1,2, 4-triazol-4-yl]ethyl]-argininamid (BIIE0246) on neuropeptide release from rat hypothalamic slices in vitro.
P J, King, G, Williams, H, Doods, P S, Widdowson   +3 more
openaire   +2 more sources

Neuropeptide Y receptor antagonists.

IDrugs : the investigational drugs journal, 2005
A review of the patent literature for neuropeptide Y (NPY) antagonists is presented for the period of January 2000 to March 2001. This review focuses on antagonists of the Y(1) and Y(5) receptor subtypes, which have been of primary interest as anti-obesity agents.
openaire   +1 more source

Distribution of P2Y2 receptors in the guinea pig enteric nervous system and its coexistence with P2X2 and P2X3 receptors, neuropeptide Y, nitric oxide synthase and calretinin

Histochemistry and Cell Biology, 2005
Z. Xiang, G. Burnstock
semanticscholar   +1 more source

Neuropeptide Y (NPY) Y1 Receptor Antagonists

2001
Neuropeptide Y(NPY), a 36-residue peptide amide isolated originally from porcine brain, exhibits a wide spectrum of central and peripheral activities mediated by at least six receptor subtypes denoted as Y1, Y2, Y3, Y4, Y5 and Y6 [1]. Investigations to date have implicated NPY in the pathophysiology of a number of diseases including feeding disorders ...
V. C. Dhawan, D. E. Mullins, W. T. Chance, S. Sheriff, M. Guzzi, E. M. Parker, A. Balasubramaniam   +6 more
openaire   +1 more source

Physiological and Therapeutic Roles of Neuropeptide Y on Biological Functions.

Advances in Experimental Medicine and Biology, 2019
P. Shende, D. Desai
semanticscholar   +1 more source

Neuropeptide Y receptors in pig spleen

Acta Physiologica Scandinavica, 1987
A, Härfstrand, J M, Lundberg, K, Fuxe
openaire   +2 more sources

Neuropeptide Y-induced feeding is dependent on GABAA receptors in neonatal chicks

Journal of Comparative Physiology, 2012
H. Jonaidi, bullet Z Noori
semanticscholar   +1 more source

Protective role of neuropeptide Y Y2 receptors in cell death and microglial response following methamphetamine injury

European Journal of Neuroscience, 2012
Joana Gonçalves, C. F. Ribeiro, J. Malva, A. P. Silva   +3 more
semanticscholar   +1 more source