Results 171 to 180 of about 115,139 (216)
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Evolution of neurotransmitter receptor systems
Progress in Neurobiology, 1988The presence of hormones, neurotransmitters, their receptors and biosynthetic and degradative enzymes is clearly not only associated with the present and the recent past but with the past several hundred million years. Evidence is mounting which indicates substantial conservation of protein structure and function of these receptors and enzymes over ...
J.C. Venter +8 more
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2018
Neurotransmitter receptors play a vital role in the normal functioning of the nervous system. Controlled modulation of neurotransmitter receptors is critical for proper signaling between nerve cells and effector organs. Factors that disrupt normal neurotransmitter signaling can alter the homeostasis of the cells or tissues, leading to adverse effects ...
Miranda N. Reed +3 more
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Neurotransmitter receptors play a vital role in the normal functioning of the nervous system. Controlled modulation of neurotransmitter receptors is critical for proper signaling between nerve cells and effector organs. Factors that disrupt normal neurotransmitter signaling can alter the homeostasis of the cells or tissues, leading to adverse effects ...
Miranda N. Reed +3 more
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Neurotransmitter receptor plasticity in aging
Life Sciences, 1994Neurotransmitter receptor plasticity is an important part of the compensatory processes by which the central nervous system adapts to pathological insult, long-term exposure to drugs or neuronal loss with advanced age. Receptor plasticity can be manifest as changes in the number of receptors (i.e., up- or down-regulation), changes in expression of mRNA
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Receptors for neurotransmitters and related substances
Current Opinion in Biotechnology, 1991Advances in techniques for cloning neurotransmitter receptors have revealed new targets for selective drug design. Cell systems for more efficient expression of cloned receptor genes have also been developed. Knowledge of the nature of ligand-binding sites is now becoming available and this should aid in the design of better drugs with fewer side ...
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Cetirizine: Actions on neurotransmitter receptors
Journal of Allergy and Clinical Immunology, 1990First-generation H1-antagonist antihistamines, such as hydroxyzine, have the ability to cross the blood-brain barrier and cause sedation, which limits their usefulness in the treatment of allergic disorders. Cetirizine, a carboxylated metabolite of hydroxyzine, possesses the parent compound's antihistaminic activity but causes less sedation.
Solomon H. Snyder, Adele M. Snowman
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Neurotransmitters: Elusive glutamate receptors
Current Biology, 1994Kainate-preferring glutamate receptors appear to be abundant in the central nervous system. We have recently begun to understand their properties, but their functions remain to be described.
Stuart G. Cull-Candy, Dirk Feldmeyer
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Drug and Neurotransmitter Receptors in the Brain
Science, 1984Biochemical investigation of receptors for neurotransmitters and drugs in the brain has been one of the most active areas of molecular neuroscience during the past decade. This work has permitted fundamental insights into how binding of neurotransmitters to their receptors excites or inhibits neuronal firing or changes cellular metabolism.
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Insect neurotransmission: Neurotransmitters and their receptors
Pharmacology & Therapeutics, 1996The roles of acetylcholine, dopamine, octopamine, tyramine, 5-hydroxytryptamine, histamine, glutamate, 4-aminobutanoic acid (gamma-aminobutyric acid) and a range of peptides as insect neurotransmitters are evaluated in terms of the criteria used to identify transmitters.
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Neurotransmitter receptors in brain in schizophrenia
Acta Psychiatrica Scandinavica, 1981The binding of the dopamine agonist ADTN and of ligands for the serotonin, muscarinic cholinergic, GABA, and benzodiazepine receptors was studied in 18 schizophrenic and 19 control brains. By contrast with the previously reported increase in binding of the dopamine antagonist spiperone, ADTN binding was not increased, and there was no consistent change
Alan J. Cross +4 more
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Neurotransmitters and receptors: Clinical implications
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1984With the advent of new techniques such as the radioreceptor binding assay, significant advances have been made in the field of psychopharmacology during the past seven years. In this paper we discuss some of these contributions regarding our understanding about the nature of different psychopathological conditions such as anxiety, depression and ...
Thomas A. Ban, Gabor Kato
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