Results 1 to 10 of about 2,426,857 (235)

Nicotinic receptors [PDF]

The Receptors, 2014
Regulation of normal or abnormal behaviour is critically controlled by the central serotonergic systems. Recent evidence has suggested that serotonin (5-HT) neurotransmission dysfunction contributes to a variety of pathological conditions, including ...
A Auclair, A Beyeler, A Coppen, A Dahlstrom, A Fletcher, A Fletcher, A Gobert, A Jain, A Markou, A Pazos, AC Farley, AJ Grottick, AJ Grottick, AM Batman, AS Brown, AV Prochazka, B Chang, B Lendvai, BB Brodie, BL Jacobs, BM Twarog, BR Cooper, C Cirillo, C Nocjar, C Reperant, CP Müller, D Herve, D Hoyer, D Hoyer, D Kooy van der, D Quarta, DE Nichols, DJ Balfour, DJ Hayes, DL Murphy, DL Willins, DM Tomkins, DV Herin, E Costa, E Esposito, E Quattrocki, EB Ribeiro, EC Azmitia, ED Levin, ED Levin, EJ Bockstaele Van, EJ Bockstaele Van, EJ Mills, F Jenck, G Chevalier, G Chiara Di, G Cucchiaro, G Cucchiaro, G Engberg, G Giovanni Di, G Giovanni Di, G Giovanni Di, G Giovanni Di, G Giovanni Di, G Giovanni Di, G Giovanni Di, G Giovanni Di, G Porras, G Porras, GA Higgins, GA Higgins, GA Higgins, GA Kennett, GA Kennett, GF Koob, GW Dalack, H Khalki, H Moukhles, H Rollema, H Rollema, H Rollema, H Takahashi, HD Mansvelder, J Arnt, J Dong, J Hannon, JA Ascher, JE Anderson, JE Slemmer, JF Cryan, JH Thompson, JK Abrams, JL Neisewander, JR Martin, JW Coe, K Guillem, K Touiki, KD Alex, KG Baker, KH Thomas, KJ Clemens, KL Summers, L Galindo-Charles, L Pozzi, LA Pockros, LL McMahon, M Bubser, M Costa, M Dols, M Giorgetti, M Pierucci, M Pompeiano, M Reuben, M Zaniewska, M Zaniewska, M Zaniewska, MD Doherty, ME Benwell, MF O'Neill, MJ Bubar, MJ Bubar, MJ Eisenberg, MJ Millan, MM Rapport, N Corvaja, N Maurice, NA Rigotti, NB Edwards, NG Schneider, NM Barnes, OT Phillipson, P Deurwaerdere De, P Deurwaerdere De, P Enkhbaatar, P Olausson, P Olausson, P Seth, PA Crooks, PBS Clarke, PH Hutson, PJ Fletcher, PJ Fletcher, PJ Fletcher, PJ Kenny, PJ Kenny, PM Whitaker-Azmita, RD Schwartz, RF Mucha, RM Bowker, RM Bowker, RS Bitner, RS Bitner, S Hjorth, S Mihailescu, S Navailles, S Prisco, SG Matta, SJ Bonasera, SM Hall, SM Hall, SP Ji, SP Ranade, TA Shahan, V Cornea-Hébert, V Erspamer, V Hillegaart, V Matteo Di, V Matteo Di, V Matteo Di, V Matteo Di, V Matteo Di, V Matteo Di, V Matteo Di, W Feldberg, WA Corrigall, X Li, Y Takada, Z Ma, ZJ Yu   +173 more
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Nicotinic acetylcholine receptors and epilepsy

Pharmacological Research, 2023
Despite recent advances in understanding the causes of epilepsy, especially the genetic, comprehending the biological mechanisms that lead to the epileptic phenotype remains difficult.
Andrea Becchetti, Laura Clara Grandi, Marta Cerina, Alida Amadeo   +3 more
doaj   +5 more sources

Variants in Nicotinic Receptors and Risk for Nicotine Dependence [PDF]

American Journal of Psychiatry, 2008
A recent study provisionally identified numerous genetic variants as risk factors for the transition from smoking to the development of nicotine dependence, including an amino acid change in the alpha5 nicotinic cholinergic receptor (CHRNA5). The purpose of this study was to replicate these findings in an independent data set and more thoroughly ...
John I. Nurnberger, Oliver Reyes, Danielle M. Dick, Jay A. Tischfield, Kevin Mayo, Samuel Kuperman, Sarah Bertelsen, Victor Hesselbrock, Xiaoling Xuei, Dorothy K. Hatsukami, Richard A. Grucza, Marc A. Schuckit, John Kramer, Scott F. Saccone, Bernice Porjesz, Alison Goate, John P. Budde, William J. Horton, Nancy L. Saccone, Jerry A. Stitzel, Tatiana Foroud, John P. Rice, C. Robert Cloninger, Naomi Breslau, Gary E. Swan, Louis Fox, Eric O. Johnson, Jen C. Wang, Pamela A. F. Madden, Anthony L. Hinrichs, Ovide F. Pomerleau, Laura J. Bierut, Howard J. Edenberg   +32 more
openaire   +4 more sources

Nicotinic acetylcholine receptors [PDF]

British Journal of Pharmacology, 2018
This themed section of the British Journal of Pharmacology is the product of a conference that focussed on nicotinic ACh receptors (nAChRs) that was held on the Greek island of Crete from 7 to 11 May 2017. ‘Nicotinic acetylcholine receptors 2017’ was the fourth in a series of triennial international meetings that have provided a regular forum for ...
Wonnacott, S, Bermudez, I, Millar, NS, Tzartos, SJ   +3 more
openaire   +6 more sources

Erythrina mulungu alkaloids are potent inhibitors of neuronal nicotinic receptor currents in mammalian cells. [PDF]

PLoS ONE, 2013
Crude extracts and three isolated alkaloids from Erythrina mulungu plants have shown anxiolytic effects in different animal models. We investigated whether these alkaloids could affect nicotinic acetylcholine receptors and if they are selective for ...
Pedro Setti-Perdigão, Maria A R Serrano, Otávio A Flausino, Vanderlan S Bolzani, Marília Z P Guimarães, Newton G Castro   +5 more
doaj   +1 more source

The Anti-Aggregative Peptide KLVFF Mimics Aβ1-40 in the Modulation of Nicotinic Receptors: Implications for Peptide-Based Therapy

Biomedicines, 2022
In recent years, the inhibition of beta-amyloid (Aβ) aggregation has emerged as a potential strategy for Alzheimer’s disease. KLVFF, a small peptide corresponding to the aminoacidic sequence 16-20 of Aβ, reduces Aβ fibrillation dose dependently ...
Hanna Trebesova, Guendalina Olivero, Mario Marchi, Massimo Grilli   +3 more
doaj   +1 more source

Mechanosensitivity of nicotinic receptors [PDF]

Pflügers Archiv - European Journal of Physiology, 2012
Nicotinic acetylcholine receptors (nAChRs) are heteropentameric ligand-gated ion channels that mediate excitatory neurotransmission at the neuromuscular junction (NMJ) and other peripheral and central synapses. At the NMJ, acetylcholine receptors (AChRs) are constantly exposed to mechanical stress resulting from muscle contraction.
H. Benjamin Peng, Jin Jin Ma, N. Clara Pan, N. Clara Pan   +3 more
openaire   +4 more sources

Nicotinic Receptors in Neurodegeneration [PDF]

Current Neuropharmacology, 2013
Many studies have focused on expanding our knowledge of the structure and diversity of peripheral and central nicotinic receptors. Nicotinic acetylcholine receptors (nAChRs) are members of the Cys-loop superfamily of pentameric ligand-gated ion channels, which include GABA (A and C), serotonin, and glycine receptors.
Valentín Ceña, Inmaculada Posadas, Beatriz López-Hernández   +2 more
openaire   +3 more sources

Bispyridinium Compounds Inhibit Both Muscle and Neuronal Nicotinic Acetylcholine Receptors in Human Cell Lines. [PDF]

PLoS ONE, 2015
Standard treatment of poisoning by organophosphorus anticholinesterases uses atropine to reduce the muscarinic effects of acetylcholine accumulation and oximes to reactivate acetylcholinesterase (the effectiveness of which depends on the specific ...
Avi Ring, Bjorn Oddvar Strom, Simon R Turner, Christopher M Timperley, Michael Bird, A Christopher Green, John E Chad, Franz Worek, John E H Tattersall   +8 more
doaj   +1 more source

Pharmacological receptors of nematoda as target points for action of antiparasitic drugs [PDF]

Veterinarski Glasnik, 2010
Cholinergic receptors of parasitic nematodes are one of the most important possible sites of action of antiparasitic drugs. This paper presents some of our own results of electrophysiological and pharamcological examinations of nicotinic and muscarinic ...
Trailović Saša M., Ivanović Saša R., Trailović-Nedeljković Jelena, Robertson Alan P.   +3 more
doaj   +1 more source