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Nicotinic acetylcholine receptors [PDF]

British Journal of Pharmacology, 2018
This themed section of the British Journal of Pharmacology is the product of a conference that focussed on nicotinic ACh receptors (nAChRs) that was held on the Greek island of Crete from 7 to 11 May 2017. ‘Nicotinic acetylcholine receptors 2017’ was the fourth in a series of triennial international meetings that have provided a regular forum for ...
Wonnacott, S, Bermudez, I, Millar, NS, Tzartos, SJ   +3 more
core   +6 more sources

Nicotinic acetylcholine receptors in pain modulation [PDF]

Frontiers in Pharmacology
Chronic pain is widely recognized as a major global health problem that affects approximately one-fifth of the adult population and is associated with significant physical, psychological, and socioeconomic burden.
Junya Cheng, Junliang Chang, Shuai Li
doaj   +2 more sources

Interactions between the rabies virus and nicotinic acetylcholine receptors: A potential role in rabies virus induced behavior modifications

Heliyon, 2022
Rabies causes approximately 60,000 casualties annually and has a case fatality rate approaching 100% once clinical signs occur. The glycoprotein on the surface of the virion is important for the host immune response and facilitates interaction of the ...
Marianne Lian, Karsten Hueffer, Maegan M. Weltzin   +2 more
doaj   +1 more source

Erythrina mulungu alkaloids are potent inhibitors of neuronal nicotinic receptor currents in mammalian cells. [PDF]

PLoS ONE, 2013
Crude extracts and three isolated alkaloids from Erythrina mulungu plants have shown anxiolytic effects in different animal models. We investigated whether these alkaloids could affect nicotinic acetylcholine receptors and if they are selective for ...
Pedro Setti-Perdigão, Maria A R Serrano, Otávio A Flausino, Vanderlan S Bolzani, Marília Z P Guimarães, Newton G Castro   +5 more
doaj   +1 more source

The Anti-Aggregative Peptide KLVFF Mimics Aβ1-40 in the Modulation of Nicotinic Receptors: Implications for Peptide-Based Therapy

Biomedicines, 2022
In recent years, the inhibition of beta-amyloid (Aβ) aggregation has emerged as a potential strategy for Alzheimer’s disease. KLVFF, a small peptide corresponding to the aminoacidic sequence 16-20 of Aβ, reduces Aβ fibrillation dose dependently ...
Hanna Trebesova, Guendalina Olivero, Mario Marchi, Massimo Grilli   +3 more
doaj   +1 more source

Nicotinic acetylcholine receptors in the synganglion of the tick Ixodes ricinus: Functional characterization using membrane microtransplantation

International Journal for Parasitology: Drugs and Drug Resistance, 2020
Nicotinic acetylcholine receptors are an important class of excitatory receptors in the central nervous system of arthropods. In the ticks Ixodes ricinus, the functional and pharmacological properties of nicotinic receptors located in their neurons are ...
Anaïs Le Mauff, Hamza Chouikh, Alison Cartereau, Claude L. Charvet, Cédric Neveu, Claude Rispe, Olivier Plantard, Emiliane Taillebois, Steeve H. Thany   +8 more
doaj   +1 more source

Mechanosensitivity of nicotinic receptors [PDF]

Pflügers Archiv - European Journal of Physiology, 2012
Nicotinic acetylcholine receptors (nAChRs) are heteropentameric ligand-gated ion channels that mediate excitatory neurotransmission at the neuromuscular junction (NMJ) and other peripheral and central synapses. At the NMJ, acetylcholine receptors (AChRs) are constantly exposed to mechanical stress resulting from muscle contraction.
Pan, N. Clara, Ma, Jin Jin, Peng, H. Benjamin   +2 more
openaire   +3 more sources

Nicotinic Receptors in Neurodegeneration [PDF]

Current Neuropharmacology, 2013
Many studies have focused on expanding our knowledge of the structure and diversity of peripheral and central nicotinic receptors. Nicotinic acetylcholine receptors (nAChRs) are members of the Cys-loop superfamily of pentameric ligand-gated ion channels, which include GABA (A and C), serotonin, and glycine receptors.
Posadas, Inmaculada, López-Hernández, Beatriz, Ceña, Valentín   +2 more
openaire   +2 more sources

Up-regulation of Nicotinic Receptors by Nicotine Varies with Receptor Subtype [PDF]

Journal of Biological Chemistry, 2008
Recent evidence suggests that in addition to alpha4beta2 and alpha3-containing nicotinic receptors, alpha6-containing receptors are present in midbrain dopaminergic neurons and involved in the nicotine reward pathway. Using heterologous expression, we found that alpha6beta2, like alpha3beta2 and alpha4beta2 receptors, formed high affinity epibatidine ...
Heather, Walsh, Anitha P, Govind, Ryan, Mastro, J C, Hoda, Daniel, Bertrand, Yolanda, Vallejo, William N, Green   +6 more
openaire   +2 more sources

Pharmacological receptors of nematoda as target points for action of antiparasitic drugs [PDF]

Veterinarski Glasnik, 2010
Cholinergic receptors of parasitic nematodes are one of the most important possible sites of action of antiparasitic drugs. This paper presents some of our own results of electrophysiological and pharamcological examinations of nicotinic and muscarinic ...
Trailović Saša M., Ivanović Saša R., Trailović-Nedeljković Jelena, Robertson Alan P.   +3 more
doaj   +1 more source