Results 101 to 110 of about 2,394,761 (293)

Manipulating midbrain dopamine neurons and reward-related behaviors with light-controllable nicotinic acetylcholine receptors

eLife, 2018
Dopamine (DA) neurons of the ventral tegmental area (VTA) integrate cholinergic inputs to regulate key functions such as motivation and goal-directed behaviors.
Romain Durand-de Cuttoli, Sarah Mondoloni, Fabio Marti, Damien Lemoine, Claire Nguyen, Jérémie Naudé, Thibaut d'Izarny-Gargas, Stéphanie Pons, Uwe Maskos, Dirk Trauner, Richard H Kramer, Philippe Faure, Alexandre Mourot   +12 more
doaj   +1 more source

Nicotinic acetylcholine receptors and nicotine addiction: A brief introduction

Neuropharmacology, 2020
Ruthie E. Wittenberg, S. Wolfman, M. Biasi, J. Dani   +3 more
semanticscholar   +1 more source

Nicotinic Acetylcholine Receptors in the Mesolimbic Pathway: Primary Role of Ventral Tegmental Area α6β2* Receptors in Mediating Systemic Nicotine Effects on Dopamine Release, Locomotion, and Reinforcement

Journal of Neuroscience, 2010
α6* nicotinic acetylcholine receptors (nAChRs) are highly and selectively expressed by mesostriatal dopamine (DA) neurons. These neurons are thought to mediate several behavioral effects of nicotine, including locomotion, habit learning, and ...
C. Gotti, Stefania Guiducci, V. Tedesco, S. Corbioli, L. Zanetti, M. Moretti, A. Zanardi, R. Rimondini, M. Mugnaini, F. Clementi, C. Chiamulera, M. Zoli   +11 more
semanticscholar   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Nicotinic acetylcholine receptors and cancer

Biomedical Reports, 2016
Nicotine, the primary addictive constituent of cigarettes, is believed to contribute to cancer promotion and progression through the activation of nicotinic acetylcholine receptors (nAChRs), which are membrane ligand-gated cation channels. nAChRs activation can be triggered by the neurotransmitter Ach, or certain other biological compounds, such as ...
Xianguang Meng, Haiyan Song, Ningning Dang   +2 more
openaire   +4 more sources

Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application

BMEMat, EarlyView.
The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah, Xingxing Li, Hao Yuan, Huiling Shen, Shaohao Quan, Guifang Pan, Muhammad Ishfaq, Abid Ullah Shah, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source

Evolution of vertebrate nicotinic acetylcholine receptors

BMC Evolutionary Biology, 2019
Background Many physiological processes are influenced by nicotinic acetylcholine receptors (nAChR), ranging from neuromuscular and parasympathetic signaling to modulation of the reward system and long-term memory.
Julia E. Pedersen, Christina A. Bergqvist, Dan Larhammar   +2 more
doaj   +1 more source

Periodontitis presenting among betel quid users: A case series

Clinical Advances in Periodontics, EarlyView.
Abstract Background Betel leaf chewing habit has been studied extensively, as it has been an ancient practice in many Asian countries. Although betel leaf has been reported to have potential beneficial properties, it has also been shown to have a strong association with oral diseases, including periodontitis. This case series addresses the presentation
Jungweon V. Park, Priyanka K. Pitchumani, Dimitris N. Tatakis   +2 more
wiley   +1 more source

NSAIDS AS MODULATORS OF CATION CHANNELS: FENAMATES REPURPOSING IN CHANNELOPATHIES

ChemMedChem, Accepted Article.
Cationic ion channels are transmembrane proteins that regulate the flux of cations (potassium, sodium, and calcium) across cell membrane, playing a pivotal role in many cellular functions. Disruptions of their activity can lead to the so‐called genetic or acquired channelopathies, a heterogeneous group of diseases that affect multiple human systems ...
Paola Laghetti, Concetta Altamura, Simone Dell’Atti, Jean-François Desaphy, Ilaria Saltarella   +4 more
wiley   +1 more source

Impulsive Behavior and Nicotinic Acetylcholine Receptors

Journal of Pharmacological Sciences, 2012
Higher impulsivity is thought to be a risk factor for drug addiction, criminal involvement, and suicide. Excessive levels of impulsivity are often observed in several psychiatric disorders including attention-deficit/hyperactivity disorder and ...
Yu Ohmura, Iku Tsutsui-Kimura, Mitsuhiro Yoshioka   +2 more
doaj   +1 more source