Results 101 to 110 of about 2,915 (172)

Monod-Wyman-Changeux Analysis of Ligand-Gated Ion Channel Mutants [PDF]

arXiv, 2017
We present a framework for computing the gating properties of ligand-gated ion channel mutants using the Monod-Wyman-Changeux (MWC) model of allostery. We derive simple analytic formulas for key functional properties such as the leakiness, dynamic range, half-maximal effective concentration, and effective Hill coefficient, and explore the full spectrum
arxiv  

Recent Advances in the α‐Hydrazination (α‐Amination) of Carbonyl Compounds

European Journal of Organic Chemistry, EarlyView.
In recent years, notable progress has been achieved in the α‐hydrazination (α‐amination) of carbonyl compounds, especially in the direct asymmetric electrophilic α‐hydrazination with dialkyl azodicarboxylates. This review summarizes all the methods that appeared over the past decade, categorized based on the type of the reactive chiral intermediate ...
Dina Scarpi, Samuele Visi, Ernesto G. Occhiato   +2 more
wiley   +1 more source

Vaping product access and use among 14–17‐year‐olds in New South Wales: a cross‐sectional study

Australian and New Zealand Journal of Public Health, Volume 46, Issue 6, Page 814-820, December 2022., 2022
Abstract Objectives: We assessed access to vaping products and types of products used and the factors associated with vaping and smoking among young people in the state of New South Wales (NSW), Australia. Methods: A cross‐sectional survey was conducted with a sample of 721 young people aged 14 to 17 years from NSW recruited through online panels ...
Christina Watts, Sam Egger, Anita Dessaix, Alecia Brooks, Emily Jenkinson, Paul Grogan, Becky Freeman   +6 more
wiley   +1 more source

Impaired neurovascular coupling in the APPxPS1 mouse model of Alzheimer’s disease [PDF]

arXiv, 2019
The tight coupling between neuronal activity and the local increase of blood flow termed neurovascular coupling is essential for normal brain function. This mechanism of regulation is compromised in Alzheimer's Disease (AD). In order to determine whether a purely vascular dysfunction or a neuronal alteration of blood vessels diameter control could be ...
arxiv  

Conceptual and organizational barriers to quantitative systems pharmacology modeling of pathophysiological systemic drug hypotheses

, 2022
CPT: Pharmacometrics &Systems Pharmacology, Volume 11, Issue 12, Page 1556-1559, December 2022.
Ronald Gieschke, Robert Carr
wiley   +1 more source

Manipulating midbrain dopamine neurons and reward-related behaviors with light-controllable nicotinic acetylcholine receptors

eLife, 2018
Dopamine (DA) neurons of the ventral tegmental area (VTA) integrate cholinergic inputs to regulate key functions such as motivation and goal-directed behaviors.
Romain Durand-de Cuttoli, Sarah Mondoloni, Fabio Marti, Damien Lemoine, Claire Nguyen, Jérémie Naudé, Thibaut d'Izarny-Gargas, Stéphanie Pons, Uwe Maskos, Dirk Trauner, Richard H Kramer, Philippe Faure, Alexandre Mourot   +12 more
doaj   +1 more source

PAK3 pathogenic variant associated with sleep‐related hypermotor epilepsy in a family with parental mosaicism

Epilepsia Open, EarlyView.
Abstract Protein‐activated kinases mediate spine morphogenesis and synaptic plasticity. PAK3 is part of the p21‐activated kinases (PAKs) family of Ras‐signaling serine/threonine kinases. Pathogenic variants in the X‐linked gene PAK3 have been described in patients with neurodevelopmental syndromes.
Antonio Gambardella, Yu‐Chi Liu, Mark F. Bennett, Timothy E. Green, John A. Damiano, Francesco Fortunato, Matthew J. Coleman, Jacqueline Cherfils, Jean‐Vianney Barnier, Jozef Gecz, Melanie Bahlo, Samuel F. Berkovic, Michael S. Hildebrand   +12 more
wiley   +1 more source

Personality Functioning in Inpatients With Eating Disorders: Association With Symptom Severity and Treatment Outcome

European Eating Disorders Review, EarlyView.
ABSTRACT Objective Impairment in personality functioning (PF) has been linked to a number of mental disorders, including eating disorders (EDs). However, the precise relationship between PF and symptom severity, as well as the potential impact on outcome, remains unclear.
Sophia Heinzmann, Sonja Etzler, Armin Hartmann, Eva M. Klein, Stephan Herpertz, Magdalena Pape, Stanislav Heinzmann, Stephan Doering, Tobias Hofmann, Matthias Rose, Katrin Imbierowicz, Franziska Geiser, Antonie Bierling, Kerstin Weidner, Jörg Rademacher, Silke Michalek, Eva Morawa, Yesim Erim, Eva‐Maria Skoda, Martin Teufel, Eva Milena Johanne Peters, Johannes Kruse, Dirk von Boetticher, Christoph Herrmann‐Lingen, Mariel Noehre, Martina de Zwaan, Ulrike Dinger, Hans‐Christoph Friederich, Alexander Niecke, Christian Albus, Rüdiger Zwerenz, Manfred Beutel, Casper Roenneberg, Peter Henningsen, Barbara Stein, Christiane Waller, Karsten Hake, Carsten Spitzer, Andreas Stengel, Stephan Zipfel, Katja Weimer, Harald Gündel, Henrik Kessler, Derek Spieler, Claas Lahmann, Almut Zeeck   +45 more
wiley   +1 more source

Autoimmunity to neuronal nicotinic acetylcholine receptors

Pharmacological Research, 2023
Nicotinic acetylcholine receptors (nAChRs) are widely expressed in many and diverse cell types, participating in various functions of cells, tissues and systems.
Maria Pechlivanidou, Elpinickie Ninou, Katerina Karagiorgou, Aikaterini Tsantila, Renato Mantegazza, Andreetta Francesca, Raffaello Furlan, Leon Dudeck, Johann Steiner, John Tzartos, Socrates Tzartos   +10 more
doaj  

Influence of nicotine and alcohol on sleep latency: the reward-attention circuit model [PDF]

arXiv, 2019
We previously developed a neurocomputational model called the reward-attention circuit, which has been used to investigate the separate effects of nicotine and alcohol on attention focus. The model is based on known circuits linking midbrain dopaminergic neurons to the thalamocortical loop and is sufficiently versatile to capture diverse phenomena.
arxiv