Results 121 to 130 of about 2,915 (172)
Mass Spectrometry Reviews, EarlyView.Abstract Affinity photolabeling is a smart method to study noncovalent and transient interactions and provide a submolecular picture of the contacts between interacting partners. In this review, we will focus on the identification of peptide partners using photoaffinity labeling coupled to mass spectrometry in different contexts such as in vitro with a
Astrid Walrant, Emmanuelle Sachon
wiley +1 more source
Movement Disorders, EarlyView.Abstract Objective To update evidence‐based medicine recommendations for treating motor fluctuations of Parkinson's disease (PD). Background The International Parkinson and Movement Disorder Society (MDS) Evidence Based Medicine in Movement Disorders Committee recommendations for the treatments of PD were first published in 2002 and regularly updated ...
Rob M.A. de Bie +21 more
wiley +1 more source
Cholinergic System Changes in Dopa‐Unresponsive Freezing of Gait in Parkinson's Disease
Movement Disorders, EarlyView.Abstract Background Freezing of gait (FoG) is a debilitating mobility disturbance that becomes increasingly resistant to dopaminergic pharmacotherapies with advancing Parkinson's disease (PD). The pathophysiology underlying the response of FoG to dopaminergic treatment is poorly understood.
Kelvin L. Chou +6 more
wiley +1 more source
Andrology, Volume 11, Issue 2, Page 257-269, February 2023., 2023 Abstract Introduction Erectile dysfunction is associated with diabetes mellitus with an estimated prevalence of 52.5% in the diabetic population. The first‐line therapy for erectile dysfunction is phosphodiesterase type 5 inhibitors, but data suggest that diabetic men may be less responsive than non‐diabetic men.
Axel Alberto Cayetano‐Alcaraz +4 more
wiley +1 more source
Data in Brief, 2016 Weekly submission of rats to active avoidance apparatus can be considered a neurostimulation strategy, once it can improve memory and can increase the density of receptors from different neurotransmitter systems in brain areas related to memory.
Natalia Mendes Schöwe +3 more
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Light‐Activated Pharmacological Tools for Exploring the Cholinergic System
Medicinal Research Reviews, EarlyView.ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni +5 more
wiley +1 more source
Evaluating Outcomes in Septorhinoplasty Procedures Using Serum Cotinine as a Measure for Tobacco Use
Otolaryngology–Head and Neck Surgery, EarlyView.Abstract Objective Perioperative tobacco use is associated with poor wound healing postoperative complications. The purpose of this study is to use serum cotinine as a measure of tobacco consumption to evaluate complication rates and outcomes in patients undergoing septorhinoplasty procedures. Study Design Prospective study.
Kimberly Chan +4 more
wiley +1 more source
British Journal of Clinical Pharmacology, Volume 89, Issue 1, Page 279-289, January 2023., 2023 Aims Active vitamin D deficiency is associated with increased aortic‐pulse wave velocity (Ao‐PWV) in people with type 2 diabetes (T2DM) and chronic kidney disease (CKD). There are no randomised controlled trials investigating the effect of active vitamin D treatment on Ao‐PWV in people with T2DM and CKD.
Janaka Karalliedde +10 more
wiley +1 more source
Basic &Clinical Pharmacology &Toxicology, Volume 132, Issue 2, Page 197-210, February 2023., 2023 Abstract Chronic intraperitoneal injection of thioacetamide (TAA) in rats has been used as an animal model of human cirrhosis to study the effects of the disease on drug metabolism. However, TAA inhibits P450 enzymes directly and independently of cirrhosis. We investigated the effects of chronic cirrhosis in rats, induced by 10 weeks of intraperitoneal
Devaraj Venkatapura Chandrashekar +3 more
wiley +1 more source
Impulsive Behavior and Nicotinic Acetylcholine Receptors
Journal of Pharmacological Sciences, 2012 Higher impulsivity is thought to be a risk factor for drug addiction, criminal involvement, and suicide. Excessive levels of impulsivity are often observed in several psychiatric disorders including attention-deficit/hyperactivity disorder and ...
Yu Ohmura +2 more
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