Results 11 to 20 of about 2,466,892 (329)
Up-regulation of Nicotinic Receptors by Nicotine Varies with Receptor Subtype [PDF]
Journal of Biological Chemistry, 2008 Recent evidence suggests that in addition to alpha4beta2 and alpha3-containing nicotinic receptors, alpha6-containing receptors are present in midbrain dopaminergic neurons and involved in the nicotine reward pathway. Using heterologous expression, we found that alpha6beta2, like alpha3beta2 and alpha4beta2 receptors, formed high affinity epibatidine ...
Heather, Walsh +6 more
openaire +2 more sources
Pharmacological receptors of nematoda as target points for action of antiparasitic drugs [PDF]
Veterinarski Glasnik, 2010 Cholinergic receptors of parasitic nematodes are one of the most important possible sites of action of antiparasitic drugs. This paper presents some of our own results of electrophysiological and pharamcological examinations of nicotinic and muscarinic ...
Trailović Saša M. +3 more
doaj +1 more source
Bispyridinium Compounds Inhibit Both Muscle and Neuronal Nicotinic Acetylcholine Receptors in Human Cell Lines. [PDF]
PLoS ONE, 2015 Standard treatment of poisoning by organophosphorus anticholinesterases uses atropine to reduce the muscarinic effects of acetylcholine accumulation and oximes to reactivate acetylcholinesterase (the effectiveness of which depends on the specific ...
Avi Ring +8 more
doaj +1 more source
Differential Contribution of Subunit Interfaces to α 9 α 10 Nicotinic Acetylcholine Receptor Function [PDF]
, 2017 Nicotinic acetylcholine receptors can be assembled from either homomeric or heteromeric pentameric subunit combinations. At the interface of the extracellular domains of adjacent subunits lies the acetylcholine binding site, composed of a principal ...
Boffi, Juan Carlos +11 more
core +3 more sources
Does kynurenic acid act on nicotinic receptors? An assessment of the evidence
Journal of Neurochemistry, 2019 As a major metabolite of kynurenine in the oxidative metabolism of tryptophan, kynurenic acid is of considerable biological and clinical importance as an endogenous antagonist of glutamate in the central nervous system. It is most active as an antagonist
T. Stone
semanticscholar +1 more source
Nicotine and nicotinic receptors in the circadian system
Psychoneuroendocrinology, 1998 Considerable data support a role for cholinergic influences on the circadian system. The extent to which these influences are mediated by nicotinic acetylcholine receptors (nAChRs) has been controversial, as have the specific actions of nicotine and acetylcholine in the suprachiasmatic nucleus (SCN) of the hypothalamus.
B F, O'Hara +6 more
openaire +2 more sources
Cloning and characterization of the hamster and guinea pig nicotinic acid receptors
Journal of Lipid Research, 2007 In this study, we present the identification and characterization of hamster and guinea pig nicotinic acid receptors. The hamster receptor shares ∼80–90% identity with the nucleotide and amino acid sequences of human, mouse, and rat receptors. The guinea
April Smith Torhan +3 more
doaj +1 more source
Live-Cell Imaging of Single Receptor Composition Using Zero-Mode Waveguide Nanostructures [PDF]
, 2012 We exploit the optical and spatial features of subwavelength nanostructures to examine individual receptors on the plasma membrane of living cells. Receptors were sequestered in portions of the membrane projected into zero-mode waveguides.
Dougherty, Dennis A. +6 more
core +1 more source
Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors
Current Neuropharmacology, 2018 Neuronal nicotinic acetylcholine receptors (nAChRs) belong to a super-family of Cys-loop ligand-gated ion chan-nels that respond to endogenous acetylcholine (ACh) or other cholinergic ligands.
M. Zoli +3 more
semanticscholar +1 more source
Animal bioscience, 2022 Objective Muscle acetylcholine receptors have five alpha subunits (α, β, δ, ɛ, or γ), and cholinergic receptor nicotinic gamma subunit (CHRNG) is the γ subunit.
Jiawei Du +6 more
semanticscholar +1 more source