Results 11 to 20 of about 2,426,956 (334)
Up-regulation of Nicotinic Receptors by Nicotine Varies with Receptor Subtype [PDF]
Journal of Biological Chemistry, 2008 Recent evidence suggests that in addition to alpha4beta2 and alpha3-containing nicotinic receptors, alpha6-containing receptors are present in midbrain dopaminergic neurons and involved in the nicotine reward pathway. Using heterologous expression, we found that alpha6beta2, like alpha3beta2 and alpha4beta2 receptors, formed high affinity epibatidine ...
Jean-Charles Hoda +6 more
openaire +3 more sources
Alpha9 nicotinic acetylcholine receptors and the treatment of pain [PDF]
, 2009 Chronic pain is a vexing worldwide problem that causes substantial disability and consumes significant medical resources. Although there are numerous analgesic medications, these work through a small set of molecular mechanisms.
Absalom, Nathan +4 more
core +1 more source
Arachidonic Acid as a Possible Negative Feedback Inhibitor of Nicotinic Acetylcholine Receptors on Neurons [PDF]
, 1995 Neuronal acetylcholine receptors, being highly permeable to calcium, are likely to regulate calcium-dependent events in neurons. Arachidonic acid is a membrane-permeant second messenger that can be released from membrane phospholipids by phospholipases ...
Berg, Darwin K. +3 more
core +2 more sources
Does kynurenic acid act on nicotinic receptors? An assessment of the evidence
Journal of Neurochemistry, 2019 As a major metabolite of kynurenine in the oxidative metabolism of tryptophan, kynurenic acid is of considerable biological and clinical importance as an endogenous antagonist of glutamate in the central nervous system. It is most active as an antagonist
T. Stone
semanticscholar +1 more source
Animal bioscience, 2022 Objective Muscle acetylcholine receptors have five alpha subunits (α, β, δ, ɛ, or γ), and cholinergic receptor nicotinic gamma subunit (CHRNG) is the γ subunit.
Jiawei Du +6 more
semanticscholar +1 more source
Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors
Current Neuropharmacology, 2018 Neuronal nicotinic acetylcholine receptors (nAChRs) belong to a super-family of Cys-loop ligand-gated ion chan-nels that respond to endogenous acetylcholine (ACh) or other cholinergic ligands.
M. Zoli +3 more
semanticscholar +1 more source
Expression and function of nicotinic acetylcholine receptors in stem cells
AIMS Bioengineering, 2016 Nicotinic acetylcholine receptors are prototypical ligand gated ion channels typically found in muscular and neuronal tissues. Functional nicotinic acetylcholine receptors, however, have also recently been identified on other cell types, including stem ...
Herman S. Cheung +2 more
doaj +1 more source
Curiouser and Curiouser: The Macrocyclic Lactone, Abamectin, Is also a Potent Inhibitor of Pyrantel/Tribendimidine Nicotinic Acetylcholine Receptors of Gastro-Intestinal Worms. [PDF]
PLoS ONE, 2016 Nematode parasites may be controlled with drugs, but their regular application has given rise to concerns about the development of resistance. Drug combinations may be more effective than single drugs and delay the onset of resistance.
Melanie Abongwa +3 more
doaj +1 more source
The Hair Cell α9α10 Nicotinic Acetylcholine Receptor: Odd Cousin in an Old Family
Frontiers in Cellular Neuroscience, 2021 Nicotinic acetylcholine receptors (nAChRs) are a subfamily of pentameric ligand-gated ion channels with members identified in most eumetazoan clades.
Marcela Lipovsek +2 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2015 Acetylcholine (ACh) release onto nicotinic receptors directly activates subsets of inhibitory interneurons in hippocampal CA1. However, the specific interneurons activated and their effect on the hippocampal network is not completely understood ...
L. Andrew Bell +2 more
doaj +1 more source