Results 201 to 210 of about 2,466,892 (329)

Toxicity of Four Common Environmental Chemicals Across Caenorhabditis elegans Life Stages Supporting the One Health Concept

Environmental Toxicology, EarlyView.
ABSTRACT Pesticides and pharmaceuticals are among the most common chemical groups in waterbodies and soils, and their universal distribution raises concerns about potential adverse effects on nontarget organisms and humans. Reproductive output disruption is of particular concern, as it transposes effects from the individual to the next generations at ...
Fábio Campos, Maria D. Pavlaki, Amadeu M. V. M. Soares, Susana Loureiro   +3 more
wiley   +1 more source

Cholinergic system in schizophrenia: A systematic review and meta-analysis. [PDF]

Mol Psychiatry
Saint-Georges Z, MacDonald J, Al-Khalili R, Hamati R, Solmi M, Keshavan MS, Tuominen L, Guimond S.   +7 more
europepmc   +1 more source

Neural mechanisms and clinical features of anti‐influenza drug‐related psychiatric adverse events

VIEW, EarlyView.
Anti–influenza drugs, while essential, have been increasingly associated with psychiatric adverse events (pAEs). Our study systematically investigated these pAEs by utilizing large pharmacovigilance databases and animal models, thereby revealing key clinical features and underlying neural mechanisms.
Anqi Lin, Tong Jiang, Chaofan Fan, Yihan Gao, Dan Shan, Qingxi Zhang, Kun Huang, Peng Luo, Shuofeng Yuan, Xin Chen   +9 more
wiley   +1 more source

Rational Use of Bethanechol in Dogs and Cats with Bladder Dysfunction. [PDF]

Vet Sci
Galluzzi F, Menozzi A, Saleri R, De Rensis F, Spattini G.   +4 more
europepmc   +1 more source

Silibinin‐driven microbial and metabolic reprogramming restores CD4+ T cell immunity in HIV immunological nonresponders

VIEW, EarlyView.
Despite efficacious antiretroviral therapy, 10%–40% of HIV‐infected individuals exhibit inadequate immune reconstitution due to persistent inflammatory activation and NAD+ metabolic dysregulation—a critical cofactor in cellular bioenergetics. We administered silibinin to 53 HIV immunological non‐responders and elucidated its mechanism through selective
Wenli Liu, Minghui An, Qi Wang, Yuxin Shang, Shuyao Zang, Haibo Ding, Shuai Fu, Yun Liu, Xue Dong, Xiao Yang, Jinna Dai, Xiaoxu Han, Yingchun Xu, Hong Shang   +13 more
wiley   +1 more source

Paradoxical Regulation of α7nAChR and NLRP3 Inflammasome in Gastrointestinal Cancers and Ulcerative Colitis. [PDF]

Metabolites
Ates G, Ozgur I, Sormaz IC.
europepmc   +1 more source

Management of Vocal Fold Leukoplakia

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Vocal fold leukoplakia (VFL) is a descriptive term for a white plaque in the true vocal folds (TVF). It is estimated at 10.2 cases per 100,000 males and 2.1 per 100,000 females. The most critical aspect of managing a VLF is achieving an accurate pathological diagnosis, since a white plaque in the TVF can have numerous differential diagnoses ...
Isabela H. Schettini, Thomas L. Carroll
wiley   +1 more source

Reduction of the Ca²⁺ permeability of ligand-gated ion channels as a strategy against excitotoxicity. [PDF]

Front Cell Neurosci
D'Andrea T, Fucile S.
europepmc   +1 more source

A new mixed‐ligand Cu(II) coordination polymer regulates cholinesterase activity and values on detoxifies organophosphorus poisoning Bioactivity study of Cu(II) coordination polymer (CP)

Micro &Nano Letters, Accepted Article.
Abstract Through the reaction of Cu(NO3)2·3H2O with 1,3‐di(4‐pyridyl)propane (dpp) and potassium borate (OrK), the preparation of a new coordination polymer (CP) containing Cu(II) showing two dimensional (2D) framework was successfully conducted, of which the chemical formula is [Cu8(Or)8(dpp)4(H2O)8]n (1).
Xu Lin, Xiao‐Hong Jin, Yu‐Ting Ye
wiley   +1 more source

The NMDA Receptor Antagonist Memantine Modulates Aging and Stress Resilience

Aging Cell, EarlyView.
Memantine, an NMDA receptor antagonist, extends lifespan and enhances stress resilience in C. elegans through caloric restriction–like metabolic adaptations, including reduced oxidative stress and increased fatty acid β‐oxidation, revealing a conserved mechanism linking glutamatergic signaling to healthy aging.
Vaida Juozaityte, Chiara Pregnolato, Steffen Abay‐Nørgaard, Dylan Matthew Rausch, Rebecca L. McIntyre, Zachary Gerhart‐Hines, Tune H. Pers, Anna Elisabetta Salcini, Christoffer Clemmensen   +8 more
wiley   +1 more source