Results 141 to 150 of about 611,342 (249)
Notch signaling in cancers: mechanism and potential therapy
Frontiers in Cell and Developmental BiologyThe Notch signaling pathway is an evolutionarily conserved intercellular signaling cascade that regulates a number of cellular processes, including cell development, proliferation, apoptosis, and genome stability. The Notch signaling pathway is pervasive
Chen Chen +5 more
doaj +1 more source
Epithelial Notch signaling regulates lung alveolar morphogenesis and airway epithelial integrity
, 2017 Abnormal enlargement of the alveolar spaces is a hallmark of conditions such as chronic obstructive pulmonary disease and bronchopulmonary dysplasia.
林泰元;曹伯年;魏淑? +1 more
core +1 more source
Preserving Motor Features by Alternative Re‐Referencing to Remove Heart Artifact on the Stentrode
Advanced Science, EarlyView.Endovascular brain‐computer interfaces record neural activity from within cerebrovasculature, at the expense of electrocardiogram contamination. Band‐limited independent component analysis separates this heart‐based artifact from task‐relevant neural activity in each frequency band, enabling the reconstruction of cleaner neural recordings without the ...
Ariel K. Feldman +11 more
wiley +1 more source
The Role of the Notch-3 Receptor in Stemness, EMT, and Tumorigenesis in Colorectal Cancer
, 2023 As the second leading cause of cancer death worldwide, colorectal cancer (CRC) poses a significant threat to both men and women alike. Although a small percentage of CRC cases are inherited, the majority of cases arise from environmental causes and are ...
NC DOCKS at East Carolina University +1 more
core
Advanced Science, EarlyView.NSD2 coordinates the neurogenic‐to‐gliogenic transition in the developing neocortex through H3K36me2‐dependent activation of EGFR–ERK signaling. Loss of NSD2 disrupts astroglial and oligodendroglial development, whereas ERK activation rescues gliogenic defects in vitro and in vivo.
Hanxue Chen +7 more
wiley +1 more source
, 2017 Multiple myeloma (MM) is an incurable hematological tumor stemming from malignant plasma cells. MM cell localization in the bone marrow (BM) niche allows to establish complex interactions with normal stroma, which promote neoplastic cell growth, survival,
S. Galletti +14 more
core +2 more sources
Advanced Science, EarlyView.A soft hybrid multi‐wavelength PPG wearable acquires neonatal signals. Synchronized PPG and invasive ABP data are segmented into fixed windows. A 1D‐EfficientNet model predicts segment‐level SBP and DBP. Model performance is examined with retrospective subgroup analysis across acquisition conditions.
Wenqi Shi +12 more
wiley +1 more source
Advanced Science, EarlyView.A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu +12 more
wiley +1 more source
Cell-free expression and molecular modeling of the γ-secretase complex and G-protein-coupled receptors [PDF]
, 2013 Alzheimer’s disease (AD), which was first reported more than a century ago by Alhzeimer, is one of the commonest forms of dementia which affects >30 million people globally (>8 million in Europe).
Ghoshdastider, Umesh
core
Dual Lineages of Langerhans Cells Cooperate to Restore the Immune Barrier after Skin Injury
Advanced Science, EarlyView.After skin injury, the epidermal immune barrier is rebuilt by two sources of Langerhans cells. Resident Langerhans cells first move into the wound during re‐epithelialization, guided by CXCR2 signaling. Later, recruited monocytes become long‐lived Langerhans cells.
Axel D. Schmitter‐Sánchez +8 more
wiley +1 more source