Results 131 to 140 of about 611,342 (249)

Gene expression analysis of Notch signaling pathway receptors in colon cancer stem cells.

, 2012
29 Background: The Notch signaling pathway is not only involved in cell differentiation, but also in carcinogenesis. Four different receptors are included in this pathway (Notch-1, Notch-2, Notch-3, and Notch-4) and each is encoded by a different gene.
Panagiotis Apostolou, Marina Chatziioannou, Eleni Ioannou, Ioannis Papasotiriou, Maria Toloudi   +4 more
core   +1 more source

Assessing Strengths and Limitations of Magnetoencephalography Source Imaging With Intracerebral EEG

Advanced Science, EarlyView.
Simultaneous MEG and stereotactic EEG (SEEG) recordings provide a direct validation framework for MEG source imaging in focal epilepsy. Virtual SEEG signals derived from MEG reconstructions reveal significant agreement with intracranial measures of spike localization, resting‐state oscillations, and functional connectivity, while also identifying ...
Jawata Afnan, Maria Fratello, Francesca Bonini, Samuel Medina Villalon, Zhengchen Cai, Jean‐Marc Lina, Jean‐Michel Badier, Fabrice Bartolomei, Jean Gotman, Christian G. Bénar, Christophe Grova   +10 more
wiley   +1 more source

Longitudinal Single‐Axon‐Resolution Imaging of Peripheral Nerve Injury Response in Mice Using an Optical Window Implant

Advanced Science, EarlyView.
A minimally invasive optical window enables stable, long‐term imaging of peripheral nerves in vivo at single‐axon resolution. Dynamic processes of degeneration, regeneration, and cellular remodeling are visualized across multiple time scales within the same nerve region, providing a unique platform to study a variety of anatomical and molecular events ...
Igor D. Luzhansky, Emma Anisman, Ron Perez, Sophia Zhang, Morgan Hoffman, Daniel Hunter, Abigail Cherian, Jevon Bonner, Emilia Feria, Ahmed Ahmed, Muneeb Malik, Junwei Du, Leland C. Sudlow, David M. Brogan, Matthew D. Wood, Mikhail Y. Berezin   +15 more
wiley   +1 more source

Notch signaling in cancer: metabolic reprogramming and therapeutic implications

Frontiers in Immunology
The evolutionarily conserved Notch signaling pathway is essential for cell-fate determination, organogenesis, and tissue homeostasis. Notch receptors and their ligands are transmembrane proteins with epidermal growth factor–like repeats; ligand–receptor ...
Shuang-Shuang Wang, Shuang-Shuang Wang, Shuang-Shuang Wang, Hui-Lin Lv, Hui-Lin Lv, Hui-Lin Lv, Rong-Zu Nie, Rong-Zu Nie, Rong-Zu Nie, Ya-Ping Liu, Ya-Ping Liu, Ya-Ping Liu, Yan-Jie Hou, Yan-Jie Hou, Yan-Jie Hou, Chen Chen, Chen Chen, Chen Chen, Xing-Yue Tao, Xing-Yue Tao, Xing-Yue Tao, Huo-Min Luo, Huo-Min Luo, Huo-Min Luo, Pei-Feng Li, Pei-Feng Li, Pei-Feng Li   +26 more
doaj   +1 more source

Identification of an Osteochondral Erosion Process in Gout Driven by Fibrinogen‐Integrin Activation and Local MSU Crystallization

Advanced Science, EarlyView.
Cartilage injury promotes local fibrinogen deposition, which accelerates monosodium urate crystallization and activates integrin‐mediated matrix‐degradation. This self‐amplifying cycle drives gout‐related cartilage erosion. Disrupting fibrinogen deposition or restoring the cartilage barrier could interrupt this vicious cycle.
Hanlin Xu, Simin Bi, Zhechen Liu, Xiaofeng Zhou, Hengwei Qin, Nicola Dalbeth, Minbiao Ji, Yinghui Hua   +7 more
wiley   +1 more source

A Printed Hydrogel Hybrid Electronic System With Thermoresponsive Adhesion for Neurophysiological Monitoring

Advanced Science, EarlyView.
This work develops a soft hybrid electronic system with printed thermoresponsive hydrogel electrodes, which enables high‐fidelity neural signal acquisition and stimulation. The system precisely assesses median and ulnar nerve injuries in clinical cases, realizing accurate diagnosis of neural impairment while ensuring customized adhesion regulation ...
Bo Pang, Ganguang Yang, Jiacheng Wen, Hangyu Gong, Caixin Gong, Yuqi Qiu, Zhixin Wang, Qingyang Zheng, Sen Zhou, Tianzhao Bu, Jia Tian, Zhouping Yin, Yutian Liu, Hao Wu   +13 more
wiley   +1 more source

The Role of Notch Receptors in the Alloimmune Response

, 2015
Notch receptors are a family of highly conserved transmembrane receptors crucial to cell development and fate: Notch-1 plays a critical role in normal T cell development, and is further involved in T cell activation and differentiation, while Notch-2 is ...
Ciara N. Magee (7959620)
core   +1 more source

Kresling Origami‐Based Metamaterial Robot for Dynamic Electromagnetic Control

Advanced Science, EarlyView.
A reconfigurable metamaterial system integrates deformable origami units with high‐permittivity ceramic plates. Pneumatic switching between structural states alters local resonance conditions, enabling dynamic radar stealth and adaptive microwave reflection for mobile communication.
Xinxi Zeng, Long Zhou, Shaojie Xi, Yixuan Gao, Desheng Pan, Chaoyang Sun, Haoxin Sun, Xian Wang, Lingyun Qian, Peipei Li, Pengfei Zhu, Bo Li, Jiang Luo, Ji Zhou   +13 more
wiley   +1 more source

ZBTB11 Promotes Breast Cancer Progression by Activating FBXO28‐Mediated MST1 Degradation and Suppressing Hippo Signaling

Advanced Science, EarlyView.
ZBTB11 is identified as an oncogenic transcription factor that activates FBXO28 in breast cancer. FBXO28 promotes K48‐linked ubiquitination and degradation of MST1, suppressing Hippo signaling and enhancing epithelial–mesenchymal transition and metastasis. This transcription‐to‐ubiquitination cascade defines a prognostic biomarker axis and highlights a
An Xu, Xiang‐Nan Xu, Xiao Huang, Zhou Luo, Chun‐Lian Li, Yang Du, Cheng Yan, Xiao‐Jie Yu, Jian‐Wen Wang, Long‐Di Yao, De‐Yuan Fu   +10 more
wiley   +1 more source

A Dual‐Modal Wearable PPG Smartwatch with AI‐Enhanced Correction for High‐Accuracy and Continuous AF Burden Assessment

Advanced Science, EarlyView.
ABSTRACT Atrial fibrillation (AF) increases the risk of stroke and heart failure, yet accurate quantification of AF burden in daily life remains difficult. Although smartwatch photoplethysmography (PPG) supports continuous monitoring, complex rhythms and signal noise can impair burden estimation.
Song Zuo, Jinglei Wang, Xin Wang, Han Feng, Yize Zhao, Fadong Li, Shaobin Wei, Le Zhou, Zixu Zhao, Songjie Chen, Xiangyi Kong, Jue Wang, Liu He, Shijun Xia, Xin Li, Junmeng Zhang, Xiaoxia Liu, Xueyuan Guo, Ning Zhou, Songnan Li, Chenxi Jiang, Ribo Tang, Caihua Sang, Deyong Long, Xin Du, Jianzeng Dong, Wenwu Zhu, Changsheng Ma   +27 more
wiley   +1 more source