Results 201 to 210 of about 611,342 (249)

Educating agents of change: Investigating curricula to foster sustainability competencies in university

The Curriculum Journal, EarlyView.
Abstract This study critically evaluates the implementation of sustainability competencies in the university‐wide curriculum reform at a Nordic research‐intensive multidisciplinary university. The focus is on assessing how sustainability competencies—especially the newly introduced systems thinking, strategic thinking and futures thinking—are ...
I. Södervik, T. Tuononen, R. Ratvio, T. Laisi, J. Pietikäinen   +4 more
wiley   +1 more source

The association between neural crest‐derived glia and melanocyte lineages throughout development and disease

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Secretopathies emerge as a new class of neurocristopathies

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient embryonic population of cells that give rise to a wide range of structures, including craniofacial cartilage and bone, peripheral neurons and glia, as well as components of the cardiac outflow tract, among others.
Amanda Teixeira, Cassandra Millet‐Boureima, Joshua A. Moore, Loydie A. Jerome‐Majewska   +3 more
wiley   +1 more source

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Notch receptors and hematopoiesis

Experimental Hematology, 2001
Notch receptors are involved in a variety of cell-fate decisions that affect the development and function of many organs, including hematopoiesis and the immune system. There are four mammalian Notch receptors that have only partially overlapping functions despite sharing similar structures and ligands.
S, Kojika, J D, Griffin
openaire   +2 more sources

The Notch-1 receptor in prostate tumorigenesis

Cancer Treatment Reviews, 2017
The Notch signalling pathway plays a fundamental role in tissue development due to its involvement in cell fate determination and postnatal tissue differentiation. Its capacity to regulate cell growth and development has been linked to the occurrence of several cancers including that of the prostate.
Rebecca, O'Brien, Laure, Marignol
openaire   +2 more sources

Endocytic Trafficking of the Notch Receptor

2018
The endosomal pathway plays an important role in several aspects of Notch signalling ranging from ligand-dependent to independent activation and also degradation of the Notch receptor. Here, we will focus on its role during receptor degradation and describe the endosomal pathway with the components that are important for Notch degradation and the ...
Björn, Schnute, Tobias, Troost, Thomas, Klein   +2 more
openaire   +2 more sources

Localization of ADAM10 and notch receptors in bone

Bone, 1999
In Drosophila melanogaster, the role of the metallodisintegrin, Kuzbanian (kuz), is thought to involve activation of the Drosophila Notch receptor that plays a role in cell-fate determination during neurogenesis and myoblast differentiation. To understand the possible function(s) of a-disintegrin and metalloproteinase (ADAM10), the mammalian ortholog ...
D J, Dallas, P G, Genever, A J, Patton, M I, Millichip, N, McKie, T M, Skerry   +5 more
openaire   +3 more sources

Notch-1 and Notch-4 Receptors as Prognostic Markers in Breast Cancer

International Journal of Surgical Pathology, 2010
Background: Studies looking at immunohistochemical (IHC) staining of Notch receptors in breast cancer and correlation with known prognostic factors are sparse. Methods: IHC staining for nuclear, cytoplasmic, and membrane Notch-1 (N1), Notch-4 (N4), and Jagged-1 (JAG1) was performed and correlated with known prognostic factors.
Yao K, RIZZO, Paola, Rajan P, Albain K, Rychlik K, Shah S, Miele L.   +6 more
openaire   +2 more sources

Intracellular trafficking of Notch receptors and ligands

Experimental Cell Research, 2009
The Notch pathway represents a highly conserved signaling network, which regulates the formation and maintenance of various organ systems along development and during adulthood. Direct cell-cell contacts between ligand- and receptor-expressing cells underlie activation of the Notch pathway.
openaire   +2 more sources