Results 211 to 220 of about 611,342 (249)

Notch receptor signal transduction

Experimental Hematology, 2000
Abstract The Notch receptors participate in an evolutionarily conserved signaling pathway that regulates cell fate decisions. In hematopoiesis, Notch regulates T cell and B cell differentiation and may suppress differentiation of myeloid cells in vitro. Further, constitutive activation of Notch causes T-cell ALL in humans and mice.
L. Wu, J. Aster, J.D. Griffin
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Tugging on Notch receptor tunes signaling

Science, 2017
Signal Transduction Notch proteins are transmembrane receptors that are important in the regulation of cell fate. They are unusual in that their ligands are membrane-bound on adjacent cells. Luca et al. provide insights into the signaling interactions between Notch and its various ligands.
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Amyloid precursor protein interacts with notch receptors

Journal of Neuroscience Research, 2005
The amyloid precursor protein (APP) must fulfill important roles based on its sequence conservation from fly to human. Although multiple functions for APP have been proposed, the best-known role for this protein is as the precursor of Abeta peptide, a neurotoxic 39-43-amino acid peptide crucial to the pathogenesis of Alzheimer's disease. To investigate
Sun Young, Oh, Aviva, Ellenstein, Ci-Di, Chen, Jason D, Hinman, Eric A, Berg, Catherine E, Costello, Rina, Yamin, Rachael L, Neve, Carmela R, Abraham   +8 more
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Notch-like Neurotrophin Receptor

Science Signaling, 2010
A fragment of the p75 neurotrophin receptor appears to regulate transcription in the nucleus.
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Structural Insights into Notch Receptor-Ligand Interactions

2018
Pioneering cell aggregation experiments from the Artavanis-Tsakonas group in the late 1980's localized the core ligand recognition sequence in the Drosophila Notch receptor to epidermal growth factor-like (EGF) domains 11 and 12. Since then, advances in protein expression, structure determination methods and functional assays have enabled us to define ...
Penny A, Handford, Boguslawa, Korona, Richard, Suckling, Christina, Redfield, Susan M, Lea   +4 more
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[Signalling by Notch family receptors].

Comptes rendus des seances de la Societe de biologie et de ses filiales, 1997
From nematode to man, the transmembrane receptors of the Notch family act throughout embryonic and post-embryonic development to regulate the acquisition and/or maintenance of specific differentiative states. We will review here our current state of knowledge on Notch receptors structure and signalling activity.
F, Schweisguth, M, Gho, M, Lecourtois, V, Morel   +3 more
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Evolution of Notch Transmembrane Receptors

2010
Notch is the transmembrane receptor of a juxtacrine signalling pathway (Notch pathway) crucial for cell programming during animal development. The active Notch pathway is an innovation of the metazoan lineage: several major components of this molecular network are absent from other eukaryotes. The transmembrane multidomain protein Notch emerged through
Eve, Gazave, Renard, Emmanuelle
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Notch in Pericytes: Receptor Function and Targets

2020
Angiogenesis is the process by which pre-existing blood vessels sprout to from new ones. Mural cell recruitment to the capillary endothelium is essential for the stabilization of a newly forming vascular bed during angiogenesis and is tightly regulated. Notch signaling is a pathway that regulates vessel function and pericyte recruitment.
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NOTCH RECEPTORS WITH HINGE DOMAIN

2021
ROYBAL KOLE T, LIU RAYMOND, ZHU IOWIS
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Alagille syndrome—a notch up for the Notch receptor

Nature Genetics, 1997
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