Results 281 to 290 of about 115,206 (307)
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[Signalling by Notch family receptors].
Comptes rendus des seances de la Societe de biologie et de ses filiales, 1997From nematode to man, the transmembrane receptors of the Notch family act throughout embryonic and post-embryonic development to regulate the acquisition and/or maintenance of specific differentiative states. We will review here our current state of knowledge on Notch receptors structure and signalling activity.
F, Schweisguth +3 more
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Localization of ADAM10 and notch receptors in bone
Bone, 1999In Drosophila melanogaster, the role of the metallodisintegrin, Kuzbanian (kuz), is thought to involve activation of the Drosophila Notch receptor that plays a role in cell-fate determination during neurogenesis and myoblast differentiation. To understand the possible function(s) of a-disintegrin and metalloproteinase (ADAM10), the mammalian ortholog ...
D J, Dallas +5 more
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Evolution of Notch Transmembrane Receptors
2010Notch is the transmembrane receptor of a juxtacrine signalling pathway (Notch pathway) crucial for cell programming during animal development. The active Notch pathway is an innovation of the metazoan lineage: several major components of this molecular network are absent from other eukaryotes. The transmembrane multidomain protein Notch emerged through
Eve, Gazave, Renard, Emmanuelle
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Notch signaling pathway: architecture, disease, and therapeutics
Signal Transduction and Targeted Therapy, 2022Kongming Wu, Qian Chu
exaly
Targeting Notch in oncology: the path forward
Nature Reviews Drug Discovery, 2020Samarpan Majumder +2 more
exaly
Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update
Nature Reviews Clinical Oncology, 2015Lucio Miele, Sherry X Yang, S Percy Ivy
exaly
Notch signalling: a simple pathway becomes complex
Nature Reviews Molecular Cell Biology, 2006Sarah Bray
exaly
Notch signalling in solid tumours: a little bit of everything but not all the time
Nature Reviews Cancer, 2011Anthony J Capobianco
exaly