Results 1 to 10 of about 3,136 (222)
Pharmaceuticals, 2022 This paper proposes the design of combination opioid–adrenergic tethered compounds to enhance efficacy and specificity, lower dosage, increase duration of activity, decrease side effects, and reduce risk of developing tolerance and/or addiction ...
Robert Root-Bernstein
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Opioid Receptor-Mediated Regulation of Neurotransmission in the Brain
Frontiers in Molecular Neuroscience, 2022 Opioids mediate their effects via opioid receptors: mu, delta, and kappa. At the neuronal level, opioid receptors are generally inhibitory, presynaptically reducing neurotransmitter release and postsynaptically hyperpolarizing neurons.
Kaitlin C. Reeves +6 more
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Molecules, 2022 Opioid receptors are members of the group of G protein-couple receptors, which have been proven to be effective targets for treating severe pain. The interactions between the opioid receptors and corresponding ligands and the receptor’s activation by ...
Peng Xie +8 more
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Bidirectional Regulation of Opioid and Chemokine Function
Frontiers in Immunology, 2020 The opioid family of GPCRs consists of the classical opioid receptors, designated μ-, κ-, and δ-opioid receptors, and the orphanin-FQ receptor, and these proteins are expressed on both neuronal and hematopoietic cells.
Thomas J. Rogers
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Cocaine modulates the expression of opioid receptors and miR-let-7d in zebrafish embryos. [PDF]
PLoS ONE, 2012 Prenatal exposure to cocaine, in mammals, has been shown to interfere with the expression of opioid receptors, which can have repercussions in its activity.
Roger López-Bellido +3 more
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Frontiers in Molecular Neuroscience, 2022 Impaired chemoreflex responses are a central feature of opioid-induced respiratory depression, however, the mechanism through which mu opioid receptor agonists lead to diminished chemoreflexes is not fully understood.
Sebastian N. Maletz +5 more
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Opioid Receptors in Immune and Glial Cells—Implications for Pain Control
Frontiers in Immunology, 2020 Opioid receptors comprise μ (MOP), δ (DOP), κ (KOP), and nociceptin/orphanin FQ (NOP) receptors. Opioids are agonists of MOP, DOP, and KOP receptors, whereas nociceptin/orphanin FQ (N/OFQ) is an agonist of NOP receptors.
Halina Machelska, Melih Ö. Celik
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Interactions between $β$-endorphin and kisspeptin neurons of the ewe arcuate nucleus are modulated by photoperiod [PDF]
Journal of Neuroendocrinology, In press, 2023 Opioid peptides are well-known modulators of the central control of reproduction. Among them, dynorphin coexpressed in kisspeptin (KP) neurons of the arcuate nucleus (ARC) has been thoroughly studied for its autocrine effect on KP release through $\kappa$ opioid receptors.
arxiv +1 more source
Frontiers in Pharmacology, 2020 Opioids are the most effective analgesics used in the clinical management of cancer pain or non-cancer pain. However, chronic opioids therapy can cause many side effects including respiratory depression, nausea, sedation, itch, constipation, analgesic ...
Li Zhang +4 more
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