Results 111 to 120 of about 83,214 (263)

Heterodimerization of apelin receptor and neurotensin receptor 1 induces phosphorylation of ERK1/2 and cell proliferation via Gαq-mediated mechanism [PDF]

, 2014
Dimerization of G protein-coupled receptors (GPCRs) is crucial for receptor function including agonist affinity, efficacy, trafficking and specificity of signal transduction, including G protein coupling.
Bai, B, Cai, X, Chen, J, Chen, J, Jiang, Y, Karteris, E   +5 more
core   +2 more sources

Effects of Electroacupuncture at ST36 on Visceral Pain and Inflammatory Markers in IBS Rats

Neurogastroenterology &Motility, EarlyView.
Electroacupuncture (EA) at ST36 significantly reduced visceral pain and colonic inflammation in IBS model rats. EA increased pain thresholds, lowered AWR scores, and downregulated key inflammatory mediators (IL‐1β, IL‐6, TNF‐α, TRPV1, NF‐κB). These findings highlight ST36‐targeted EA as a promising therapeutic strategy for IBS visceral hypersensitivity
Ya‐bo Hao, Yan‐lin Liu, Xiao‐mei Wang, Kai Cheng, Qing‐yu Tu, Fei Dai, Xi‐bing Yang   +6 more
wiley   +1 more source

Nalmefene, an opioid receptor modulator, aggravates atherosclerotic plaque formation in apolipoprotein E knockout mice by enhancing oxidized low-density lipoprotein uptake in macrophages

Biochemistry and Biophysics Reports
Nalmefene, an antagonist of mu- and delta-opioid receptors and a partial agonist of kappa-opioid receptors, has shown promise in reducing alcohol consumption among patients with alcohol dependence.
Mitsuhisa Koga, Koshun Inada, Ayano Yamada, Kana Maruoka, Atsushi Yamauchi   +4 more
doaj   +1 more source

Naloxone in Buprenorphine Overdose: A Life Saving Intervention [PDF]

Journal of Clinical and Diagnostic Research
Buprenorphine acts as a partial agonist at μ-opioid and ORL-1 (nociceptin) receptors, an antagonist at κ-opioid receptors, and an agonist at σ-opioid receptors.
Aviral Ratan Srivastava, Sarbari Swaika, Tanvi Snehal Desai   +2 more
doaj   +1 more source

GABAB receptor‐mediated modulation of sensory neuron excitability: Roles of CaV2.2, G‐protein‐coupled inwardly rectifying potassium (GIRK) channels, and hyperpolarisation‐activated cyclic nucleotide‐gated (HCN) channels in human and mouse nociception

Experimental Physiology, EarlyView.
Abstract Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage‐gated calcium and potassium channels by G protein‐coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the analgesic peptide α‐conotoxin Vc1.1 activate GABAB receptors (GABABR), resulting in inhibition of CaV2.2 and ...
Mariana Brizuela, Anuja R. Bony, Sonia Garcia‐Caraballo, David J. Adams, Stuart M. Brierley   +4 more
wiley   +1 more source

The Opioid System in Temporal Lobe Epilepsy: Functional Role and Therapeutic Potential

Frontiers in Molecular Neuroscience, 2017
Temporal lobe epilepsy is considered to be one of the most common and severe forms of focal epilepsies. Patients often develop cognitive deficits and emotional blunting along the progression of the disease.
Johannes Burtscher, Christoph Schwarzer
doaj   +1 more source

Effectiveness of Psychosocial Interventions for Adults With Substance Use Disorder That Have a Co‐Occurring Common Mental Health Disorder: An Umbrella Review

Drug and Alcohol Review, Volume 45, Issue 1, January 2026.
ABSTRACT Issues People with substance use disorders can have co‐occurring mental disorders. Approach An umbrella review was conducted to identify evidence of the effectiveness of psychosocial interventions for adults (aged 18+) with substance use disorders and co‐occurring common mental health disorders.
Emma L. Simpson, Munira Essat, Ruth Wong, Sarah Stacey, Edward Day   +4 more
wiley   +1 more source

Opioid Receptors Gene Polymorphism and Heroin Dependence in Iran

Basic and Clinical Neuroscience, 2018
Introduction: Genes often have multiple polymorphisms that interact with each other and the environment in different individuals. Variability in the opioid receptors can influence opiate withdrawal and dependence.
Sara Soleimani Asl, Amir Roointan, Hugo Bergen, Shayan Amiri, Parastoo Mardani, Niloufar Ashtari, Ronak Shabani, Mehdi Mehdizadeh   +7 more
doaj  

Determining Pharmacological Selectivity of the Kappa Opioid Receptor Antagonist LY2456302 Using Pupillometry as a Translational Biomarker in Rat and Human

International Journal of Neuropsychopharmacology, 2015
Background: Selective kappa opioid receptor antagonism is a promising experimental strategy for the treatment of depression. The kappa opioid receptor antagonist, LY2456302, exhibits ~30-fold higher affinity for kappa opioid receptors over mu opioid ...
L. Rorick‐Kehn, J. Witcher, S. Lowe, C. Gonzales, M. Weller, R. Bell, J. Hart, A. Need, J. McKinzie, M. Statnick, J. Suico, D. McKinzie, S. Tauscher‐Wisniewski, C. Mitch, R. Stoltz, Conrad J. Wong   +15 more
semanticscholar   +1 more source

The varieties of the psychedelic experience: A preliminary study of the association between the reported subjective effects and the binding affinity profiles of substituted phenethylamines and tryptamines [PDF]

, 2018
Classic psychedelics are substances of paramount cultural and neuroscientific importance. A distinctive feature of psychedelic drugs is the wide range of potential subjective effects they can elicit, known to be deeply influenced by the internal state of
Erowid, Earth, Erowid, Fire, Martínez Vivot, Rocío, Pallavicini, Carla, Sanz, Camila, Tagliazucchi, Enzo Rodolfo, Zamberlan, Federico   +6 more
core   +2 more sources