Results 111 to 120 of about 25,455 (216)

Expression of adrenergic, acetylcholine and kappa opioid receptors on peripheral blood lymphocytes in patients with herpetic keratitis and those with idiopathic anterior and/or intermediate uveitis

Journal of Ophthalmology
Purpose: To assess the expression of adrenergic, acetylcholine (ACh) and opioid receptors on peripheral blood lymphocytes in patients with herpetic keratitis (HK) and those with idiopathic anterior and/or intermediate uveitis (IAIU). Methods: Thirty one
L. M. Velychko, O. V. Bogdanova, N. I. Khramenko, N. V. Konovalova, G. I. Drozhzhyna, K. V. Sereda   +5 more
doaj   +1 more source

Perspectives on Endogenous Opioids in Birds

Frontiers in Physiology, 2018
The present review summarizes the state of knowledge of endogenous opioids in birds. Endogenous opioid peptides acts in a neuromodulatory, hormonal and paracrine manner to mediate analgesic and other physiological functions.
Colin G. Scanes, Krystyna Pierzchala-Koziec   +1 more
doaj   +1 more source

Dose–Response Effects of Transcutaneous Electrical Nerve Stimulation for Chronic Low Back Pain: A Systematic Review and Meta‐Analysis

European Journal of Pain, Volume 30, Issue 2, February 2026.
ABSTRACT Background Transcutaneous electrical nerve stimulation (TENS) is a widely used non‐pharmacological method for pain management, though its effectiveness in individuals with chronic low back pain (CLBP) is uncertain. Previous studies and systematic reviews have not systematically analysed the influence of TENS dosing parameters on treatment ...
Juan J. Amer‐Cuenca, Juan F. Lisón, Francisco José Ferrer‐Sargues, Gemma Biviá‐Roig, Rosa M. Baños, Laura Badenes‐Ribera, María D. Arguisuelas   +6 more
wiley   +1 more source

Response of striosomal opioid signaling to dopamine depletion in 6-hydroxydopamine-lesioned rat model of Parkinson’s disease: a potential compensatory role.

Frontiers in Cellular Neuroscience, 2013
The opioid peptide receptors consist of three major subclasses, namely, mu, delta and kappa (MOR, DOR and KOR, respectively). They are involved in the regulation of striatal dopamine functions, and increased opioid transmissions are thought to play a ...
Hidetaka eKoizumi, Ryoma eMorigaki, Shinya eOkita, Shinji eNagahiro, Ryuji eKaji, Masanori eNakagawa, Satoshi eGoto   +6 more
doaj   +1 more source

Cryoglobulinemia: An update on classification, pathophysiology, clinical presentation, and management

Journal of Internal Medicine, Volume 299, Issue 2, Page 196-215, February 2026.
Abstract Cryoglobulinemia (CG) is defined by the presence of serum immunoglobulins that precipitate below 37°C and redissolve upon rewarming. It is classified into three types based on immunoglobulin composition. Type I, a rare form, involves monoclonal IgM or IgG and is linked to lymphoproliferative disorders.
Anna Linda Zignego, Laura Gragnani, Marcella Visentini, Riccardo Bomben, Luca Arcaini, Clodoveo Ferri, Valter Gattei, Cesare Mazzaro   +7 more
wiley   +1 more source

Adverse Effects of Opioid Dependency on Central and Peripheral Aspects of the Neuromuscular System

, 2019
Prevalence of chronic pain and health care costs have caused an escalation of opioid dependency. The current national crisis involving opioid dependency and drug overdose are growing problems that need to be addressed.
Yang, Cindy
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Glial cell type-specific changes in spinal dipeptidyl peptidase 4 expression and effects of its inhibitors in inflammatory and neuropatic pain

Scientific Reports, 2018
Altered pain sensations such as hyperalgesia and allodynia are characteristic features of various pain states, and remain difficult to treat. We have shown previously that spinal application of dipeptidyl peptidase 4 (DPP4) inhibitors induces strong ...
Kornél Király, Márk Kozsurek, Erika Lukácsi, Benjamin Barta, Alán Alpár, Tamás Balázsa, Csaba Fekete, Judit Szabon, Zsuzsanna Helyes, Kata Bölcskei, Valéria Tékus, Zsuzsanna E. Tóth, Károly Pap, Gábor Gerber, Zita Puskár   +14 more
doaj   +1 more source

The Identification of Opioid Receptors and Peptide Precursors in Human DRG Neurons Expressing Pain-Signaling Molecules Confirms Their Potential as Analgesic Targets

Cells
The presence and function of the opioidergic system in sensory dorsal root ganglia (DRG) was demonstrated in various animal models of pain. To endorse recent functional and transcriptional evidence of opioid receptors in human DRG, this study compared ...
Shaaban A. Mousa, Mohammed Shaqura, Sascha Tafelski, Jan David Wandrey, Özgür Celik, Sascha Treskatsch, Michael Schäfer   +6 more
doaj   +1 more source

Opioid drug seeking after early-life adversity: a role for delta opioid receptors

Addiction Neuroscience
Opioid use disorder (OUD) is associated with a history of early-life adversity (ELA), an association that is particularly strong in women. In a rodent model, we previously found that ELA enhances risk for opioid addiction selectively in females, but the ...
Sophia C. Levis, Matthew T. Birnie, Yiyan Xie, Noriko Kamei, Puja V. Kulkarni, Johanna S. Montesinos, Christina R. Perrone, Catherine M. Cahill, Tallie Z. Baram, Stephen V. Mahler   +9 more
doaj   +1 more source

Nociceptin attenuates the escalation of oxycodone self-administration by normalizing CeA-GABA transmission in highly addicted rats. [PDF]

, 2020
Approximately 25% of patients who are prescribed opioids for chronic pain misuse them, and 5 to 10% develop an opioid use disorder. Although the neurobiological target of opioids is well known, the molecular mechanisms that are responsible for the ...
Carrette, Lieselot LG, de Guglielmo, Giordano, George, Olivier, Kallupi, Marsida, Kononoff, Jenni, Palmer, Abraham A, Schweitzer, Paul, Solberg Woods, Leah C   +7 more
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