Results 91 to 100 of about 33,193 (249)

M3 muscarinic acetylcholine receptor facilitates the endocytosis of mu opioid receptor mediated by morphine independently of the formation of heteromeric complexes [PDF]

open access: yes, 2017
Morphine inefficiency to induce the internalization of mu opioid (MOP) receptors observed in numerous experimental models constitutes a paradigm of G-protein coupled receptor (GPCR) functional selectivity.
Alvarez-Curto, Elisa   +2 more
core   +1 more source

Psychedelic‐assisted treatment for substance use disorder: A narrative systematic review

open access: yesAddiction, EarlyView.
Abstract Background and aims This is the first systematic review of the extant literature on all major psychedelic‐assisted treatment for alcohol use disorder (AUD), tobacco use disorder (TUD) and other substance use disorders (SUD). We aimed to summarise the evidence for efficacy of psychedelic‐assisted treatment for AUD, TUD, and SUD; to evaluate its
Theodore Piper   +7 more
wiley   +1 more source

Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor. [PDF]

open access: yes, 2018
The intrinsic efficacy of orthosteric ligands acting at G-protein-coupled receptors (GPCRs) reflects their ability to stabilize active receptor states (R*) and is a major determinant of their physiological effects.
Livingston, Kathryn E   +4 more
core  

An opioid-like system regulating feeding behavior in C. elegans [PDF]

open access: yes, 2015
Neuropeptides are essential for the regulation of appetite. Here we show that neuropeptides could regulate feeding in mutants that lack neurotransmission from the motor neurons that stimulate feeding muscles. We identified nlp-24 by an RNAi screen of 115
Artyukhin, Alexander B.   +3 more
core   +3 more sources

Temporal and geographical patterns of nitazene detections in drug samples and biospecimens in the United States, 2019–2024

open access: yesAddiction, EarlyView.
Abstract Background and aims Nitazenes are a novel subclass of synthetic opioids that have been increasingly implicated in the United States (US) overdose crisis. Despite their growing presence in the illicit drug supply, national trends have not been systematically evaluated.
David T. Zhu   +3 more
wiley   +1 more source

Brief Report: Opioid‐related disorders increase patient‐directed discharge in admissions for hemorrhagic or ischemic stroke

open access: yesThe American Journal on Addictions, EarlyView.
Abstract Background and Objectives Opioid use has been linked to increased stroke incidence and severity; however, data on effects during acute stroke hospitalization are limited. Methods We used the 2016–2020 National Inpatient Sample to evaluate the effects of opioid disorders on patient‐directed discharge (PDD) and length of stay (LOS) in 3,101,545 ...
Rohan M. Shah   +3 more
wiley   +1 more source

BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates [PDF]

open access: yes, 2019
© 2019 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.Background: The marked increase in mis-use of prescription opioids has greatly affected our society. One potential solution is to develop improved analgesics which have
Cami-Kobeci, Gerta   +9 more
core   +5 more sources

Patient‐reported outcomes, postoperative pain and pain relief after day‐case surgery (POPPY): short‐term peri‐operative analgesic use

open access: yesAnaesthesia, EarlyView.
Summary Introduction An increasing proportion of complex surgical procedures are being performed in the UK as day‐cases, with variable and limited follow up. Discharge prescriptions must provide adequate analgesia, while considering the safety of the patient and public, following best practice guidance and good opioid stewardship.
Anna Ratcliffe   +2083 more
wiley   +1 more source

Beyond the Epidural: Reframing Analgesia for the Modern Oesophagectomy

open access: yesANZ Journal of Surgery, EarlyView.
A novel analgesic framework for minimally invasive oesophagectomy to facilitate functional recovery.
William Thomas Birkett   +6 more
wiley   +1 more source

Naloxone inhibits nicotine-induced receptor current and catecholamine secretion in bovine chromaffin cells [PDF]

open access: yes, 2001
Nicotine-induced catecholamine (CA) secretion and inward ionic currents were inhibited by the opioid antagonist naloxone in cultured bovine chromaffin cells.
Ceña, Valentín   +4 more
core   +1 more source

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