Results 81 to 90 of about 33,193 (249)

A guide to chemokines and their receptors [PDF]

, 2018
The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that signal through cell surface G‐protein coupled heptahelical chemokine receptors.
Braun A, Dyer DP, Garton KJ, Gupta SK, Hundelshausen P, Janssens R, Murphy PM, Sozzani S, Speck RF, Suan D, Woollard SM, Zheng Y   +11 more
core   +1 more source

Effect of butorphanol in combination with xylazine during castration of calves: A randomised trial under field conditions

Veterinary Record, EarlyView.
Abstract Background In horses, cats and dogs, the opioid butorphanol has been proven effective in management of visceral pain and for peri‐ and postoperative pain relief. The aim of this study was to evaluate physiological responses and indicators of noxious stimuli when adding butorphanol to xylazine for sedation of bull calves during surgical ...
Axel Sannö, Lovisa Snygg, Maja Wiklund, Görel Nyman   +3 more
wiley   +1 more source

Caenorhabditis elegans as a model system to identify therapeutics for alcohol use disorders [PDF]

, 2019
Alcohol use disorders (AUDs) cause serious problems in society and few effective treatments are available. Caenorhabditis elegans (C. elegans) is an excellent invertebrate model to study the neurobiological basis of human behavior with a conserved, fully
Bell, Richard L., Bredhold, Kristin E., Cheong, Mi C., Engleman, Eric A., Katner, Simon N., Neal-Beliveau, Bethany S., Steagall, Kevin B., III   +6 more
core   +1 more source

Divergence in μ and δ opioid receptor pharmacology in neurons and antinociceptive efficacy in neuropathic pain: Insights from MP135 and CYM51010. [PDF]

Br J Pharmacol
Background and purpose Opioids targeting the μ opioid receptor remain largely ineffective in neuropathic pain conditions, emphasizing the need for novel therapeutic strategies. MP135 was reported to reduce thermal nociception in naive animals by activating μ‐δ opioid receptor heteromers.
Inquimbert P, Fitterer C, Hugel S, Jesic M, Goumon Y, Andry V, Schneider S, Daubeuf F, Faouzi A, Doridot S, Majumdar S, Bihel F, Schmitt M, Massotte D.   +13 more
europepmc   +2 more sources

Prenatal Prescription Opioid Analgesic Exposure and Academic Performance in Third Grade Children: A Population‐Based Cohort Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To evaluate the association between prenatal exposure to opioids analgesics and academic performance in third grade children. Design Population‐based cohort study using linked data from New South Wales birth records, medicine dispensing data, and national standardised test results.
Bianca Varney, Helga Zoega, Malcolm B. Gillies, Claudia Bruno, Alys Havard, Antonia Shand, Natasha Nassar, Jonathan Brett   +7 more
wiley   +1 more source

The Use of Peripheral μ-Opioid Receptor Antagonists (PAMORA) in the Management of Opioid-Induced Constipation: An Update on Their Efficacy and Safety

Drug Design, Development and Therapy, 2020
Joseph V Pergolizzi Jr,1 Paul J Christo,2 Jo Ann LeQuang,1 Peter Magnusson3,4 1NEMA Research, Inc., Naples, FL, USA; 2Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medicine, Baltimore, ML, USA ...
Pergolizzi JV Jr, Christo PJ, LeQuang JA, Magnusson P   +3 more
doaj  

Impact of opioids and mu-opioid receptors on oncologic metastasis

American Journal of Cancer Research
Opioids are the most effective and widely used treatments for acute and chronic pain in patients with cancer. This review focuses on the impact of opioids and mu-opioid receptors (MORs) on the stages of oncologic metastasis. Studies have shown that opioids can facilitate tumor progression and are related to a poor prognosis in patients with cancer.
Runjia, Wang, Shuai, Li, Bomin, Wang, Gongming, Wang, Hui, Zheng   +4 more
openaire   +2 more sources

Heteromerization of endogenous mu and delta opioid receptors tunes mu opioid receptor signaling and trafficking [PDF]

, 2018
Abstract Increasing evidence indicates that native mu and delta opioid receptors can associate to form heteromers in discrete brain neuronal circuits. However, little is known about their signaling and trafficking.
Derouiche, Lyes, Ugur, Muzeyyen, Pierre, Florian, Mann, Anika, Doridot, Stéphane, Ory, Stéphane, Schulz, Stefan, Massotte, Dominique   +7 more
openaire   +1 more source

Investigation of eosin Y as a colorimetric sensor for the detection of fentanyl hydrochloride and fentanyl freebase

Journal of Forensic Sciences, EarlyView.
Abstract The increasing prevalence of fentanyl within the illegal global drug market underscores the need for rapid, low‐cost, and straightforward detection methods. Eosin Y demonstrates a measurable color change in the presence of fentanyl, making it a promising candidate for colorimetric sensing and preliminary identification of fentanyl ...
Alan J. Zhou, Melissa M. Dixon, Brady S. Gentle, Genevieve H. Dennison, Kellie L. Tuck   +4 more
wiley   +1 more source

Mechanism of opioid addiction and its intervention therapy: Focusing on the reward circuitry and mu‐opioid receptor

MedComm, 2022
Opioid abuse and addiction have become a global pandemic, posing tremendous health and social burdens. The rewarding effects and the occurrence of withdrawal symptoms are the two mainstays of opioid addiction.
Jia‐Jia Zhang, Chang‐Geng Song, Ji‐Min Dai, Ling Li, Xiang‐Min Yang, Zhi‐Nan Chen   +5 more
doaj   +1 more source