Results 161 to 170 of about 112,812 (208)

Opioids, Receptors, and Immunity

1993
The results achieved by those seeking to determine whether opioids and other drugs of abuse can affect immunity are quite astonishing given the short period of time that research has focused on this area. Despite the fact that there is no longer any question that opioids produce a variety of effects on the immune system, the extent and significance of ...
Martin W. Adler, Earl E. Henderson, Thomas J. Rogers, Toby K. Eisenstein, Ellen B. Geller   +4 more
openaire   +3 more sources

Opioids and Opioid Receptors in Peripheral Tissues

Scandinavian Journal of Gastroenterology, 1987
Opioid peptides belonging to the enkephalin, beta-endorphin or dynorphin family, acting on specific opiate receptors may be found in peripheral tissues. Enkephalins have a widespread peripheral distribution, while beta-endorphin and dynorphin may be found locally in the enteric nervous system.
Thomas Hedner, Jean Cassuto
openaire   +2 more sources

Opioids, opioid receptors, and the immune response

Drug and Alcohol Dependence, 2001
It is now clear that opioid receptors participate in the function of the cells of the immune system, and evidence suggests that opioids modulate both innate and acquired immune responses. We review literature here which establishes that mu-, kappa-, and delta-opioid compounds alter resistance to a variety of infectious agents, including the Human ...
Lois McCarthy, Judith K. Sliker, Toby K. Eisenstein, Thomas J. Rogers, Michele A. Wetzel   +4 more
openaire   +3 more sources

Regulation of Opioid Receptors by Their Endogenous Opioid Peptides

Cellular and Molecular Neurobiology, 2021
Activation of μ, δ, and κ opioid receptors by endogenous opioid peptides leads to the regulation of many emotional and physiological responses. The three major endogenous opioid peptides, β-endorphin, enkephalins, and dynorphins result from the processing of three main precursors: proopiomelanocortin, proenkephalin, and prodynorphin.
Dinah L. Ramos-Ortolaza, Dinah L. Ramos-Ortolaza, Michael D. Hayward, Srinivas Gullapalli, Hui Pan, Hui Pan, Lakshmi A. Devi, Malcom J. Low, Malcom J. Low, Ivone Gomes, John E. Pintar, Achla Gupta   +11 more
openaire   +2 more sources

Opioid Peptides and their Receptors

1982
The three agonists, methionine-enkephalin, leucine-enkephalin and beta-endorphin have different pharmacological patterns. It may be of particular importance that they vary in their relative affinities to the enkephalin and naltrexone binding sites in the brain; the former are probably related to delta-receptors prevalent in the mouse vas deferens and ...
H.W. Kosterlitz, S.J. Paterson, L.E. Robson   +2 more
openaire   +3 more sources

Oligomerization of opioid receptors

Methods, 2002
Opioid receptors belong to the family of G-protein-coupled receptors characterized by their seven transmembrane domains. The activation of these receptors by agonists such as morphine and endogenous opioid peptides leads to the activation of inhibitory G-proteins followed by a decrease in the levels of intracellular cAMP.
Julija Filipovska, Lakshmi A. Devi, Ivone Gomes, Bryen A. Jordan   +3 more
openaire   +3 more sources

ChemInform Abstract: Opioid‐Agonists and ‐Antagonists, Opioid‐Receptors

ChemInform, 1997
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
T. Siener, Susanne Drosihn, Wolfgang Brandt, C. Nachtsheim, Ulrike Holzgrabe   +4 more
openaire   +3 more sources

Opioid receptors and opioid pharmacodynamics

2005
Abstract Opioids have a long and rich pharmacology. They are widely used throughout medicine and have been invaluable. However, they come with problems, including side effects such as constipation, respiratory depression and sedation, as well as the potential of abuse.
Mellar P Davis, Gavril W Pasternak
openaire   +1 more source

Opioid peptide receptor studies. 4. Antisense oligodeoxynucleotide to the delta opioid receptor delineates opioid receptor subtypes

Regulatory Peptides, 1995
Prior work in our laboratory has identified putative subtypes of delta (delta cx-1, delta cx-2, delta ncx-1, delta ncx-2) and kappa 2 (kappa 2a and kappa 2b) receptors. Previous studies showed that chronic (three day) i.c.v. administration of antisense oligodeoxynucleotide to the cloned delta opioid receptor selectively decreased [3H][D-Ala2,D-Leu5 ...
Heng Xu, Qing Ni, Josephine Lai, Silvia N. Calderon, Kenner C. Rice, Xian Yuan Cha, Richard B. Rothman, Dorota Matecka, Frank Porreca, John S. Partilla   +9 more
openaire   +3 more sources

Regulations of opioid dependence by opioid receptor types

Pharmacology & Therapeutics, 2001
Three major types of opioid receptors, designated mu, delta, and kappa, are widely expressed in the CNS. Development of selective receptor ligands and recent cloning of each receptor have contributed greatly to our increasing knowledge of the neuropharmacological profile of each opioid receptor type.
Minoru Narita, Tsutomu Suzuki, Masahiko Funada   +2 more
openaire   +3 more sources