Ultrasound Neuromodulation (Low‐Intensity Focused Ultrasound) to Treat Knee Osteoarthritis Pain
Low‐intensity focused ultrasound is a non‐invasive neuromodulation technique that delivers mechanical forces to a deep location within the body through acoustic pressure waves without affecting tissue between the transducer and focal target. Preliminary studies involving healthy volunteers suggest focused ultrasound reversibly prevents action potential
Brian M. Ilfeld+3 more
wiley +1 more source
Strategy for effective analgesia with intravenous buprenorphine in patients with acute postoperative pain. [PDF]
Szczupak M+5 more
europepmc +1 more source
ABSTRACT Background Tanning addiction is a behavioral addiction characterized by an irrepressible desire for sun or ultraviolet light exposure. It is thought to affect 10% to 25% of the population. Objectives This study aimed to estimate the prevalence of this behavior in patients with moderate‐to‐severe psoriasis and identify associated factors ...
E. Mahé+14 more
wiley +1 more source
Tricyclic antidepressants dose-dependently modulate the biphasic activity of the TRPC5 channel through opioid receptors. [PDF]
Jeong B, Chung JY, Jun JY, Hong C.
europepmc +1 more source
ABSTRACT The study aimed to investigate the effectiveness of dexmedetomidine (Dex) as an adjuvant for ropivacaine in a thoracic paravertebral block (TPVB) combined with an erector spinae plane block (ESPB) for improving early quality of recovery and postoperative pain after transapical transcatheter aortic valve implantation (TAVI).
Gui‐Ling Dong+2 more
wiley +1 more source
Docking Simulations of G-Protein Coupled Receptors Uncover Crossover Binding Patterns of Diverse Ligands to Angiotensin, Alpha-Adrenergic and Opioid Receptors: Implications for Cardiovascular Disease and Addiction. [PDF]
Ridgway H+3 more
europepmc +1 more source
Disentangling informing participants from obtaining their consent
Abstract Introduction Pragmatic clinical trials conducted in the context of routine care frequently satisfy the regulatory criteria for a waiver of research consent. When they do, investigators and Institutional Review Boards might assume that there is no reason to communicate any information regarding the study to participants.
Patricia Pearl O'Rourke+15 more
wiley +1 more source
Suzetrigine Approval Breaks a 25-Year Silence: A New Era in Non-Opioid Acute Pain Management. [PDF]
Sibomana O, Okereke M, Hakayuwa CM.
europepmc +1 more source
A framework for health systems to assess and prioritize participation in pragmatic clinical trials
Abstract Introduction Pragmatic clinical trials (PCTs) are frequently embedded within settings in which patients receive their routine clinical care. The health care institutions that deliver routine clinical care must therefore decide how they prioritize PCTs in comparison to other institutional priorities. Yet no formal guidance yet exists to support
Stephanie R. Morain+2 more
wiley +1 more source
Suzetrigine (VX-548): Bidding goodbye to opioids: The latest oral non-opioid analgesic for acute pain. [PDF]
Chittoria K+3 more
europepmc +1 more source