Results 211 to 220 of about 2,452,900 (288)

Opioid consumption after lower limb amputation in Medicare beneficiaries

open access: yesPM&R, EarlyView.
Abstract Background Despite targeted national quality improvement initiatives, opioid prescription and use patterns after lower limb amputation are not well studied. Objective To determine risk factors associated with extended opioid use and rates of high‐risk opioid prescribing after lower limb amputation. Design and setting A retrospective population‐
Alexander N. Khouri   +5 more
wiley   +1 more source

Pain Medication in Chronic Low Back Pain. [PDF]

open access: yesLife (Basel)
Jerjir A   +4 more
europepmc   +1 more source

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai   +6 more
wiley   +1 more source

Population Pharmacokinetics and Transfer of Gabapentin When Used as a Pain Adjunct for Cesarean Deliveries

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 551-560, March 2025.
ABSTRACT Enhanced Recovery After Surgery (ERAS) protocols for cesarean deliveries (CDs) utilize multimodal pain management strategies that often include gabapentin. While gabapentin is excreted in breast milk, its pharmacokinetics in immediately postpartum lactating women are not known. This observational pharmacokinetic study (NCT05099484) enrolled 21
Rebecca Silvola   +9 more
wiley   +1 more source

Nanoparticle Therapeutics in Clinical Perspective: Classification, Marketed Products, and Regulatory Landscape

open access: yesSmall, EarlyView.
This review presents a detailed overview of clinically approved nanoparticle therapeutics, classifying them by type and discussing their unique advantages in drug delivery. It highlights regulatory challenges across global markets and emphasizes the need for adaptive approval pathways.
Nimeet Desai   +5 more
wiley   +1 more source

Medications for opioid use disorder shape immune responses during chronic HIV infection. [PDF]

open access: yesCell Rep Med
Collora JA   +10 more
europepmc   +1 more source

Effects of Transcutaneous Auricular Vagal Nerve Stimulation on Chronic Constipation: A Multicenter, Randomized Controlled Study

open access: yesUnited European Gastroenterology Journal, EarlyView.
ABSTRACT Objective The objective of this study was to investigate the efficacy of transcutaneous auricular vagal nerve stimulation (taVNS) in adult patients with chronic constipation. Design Consecutive patients who met the Rome IV criteria for chronic constipation were enrolled and randomly assigned to either the taVNS group or the sham‐taVNS group ...
Tangyi Liu   +19 more
wiley   +1 more source

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